“…Clinical experience with IGIV products has been extensive, with millions of doses administered in the past 10 years. Early concerns about potentially increased risk from higher doses of IGIV products, relative to intramuscular immunoglobulins (200 to 1,000 mg/kg per infusion versus 100 mg/kg per injection), have not materialized (10,34,38). There are isolated exceptions to this general record of viral safety.…”