Human Immunodeficiency Virus Associated Nephropathy (HIVAN)

Rao, T. K. Sreepada

doi:10.1007/978-3-662-35158-1_44

Cited by 18 publications

(33 citation statements)

References 9 publications

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“…Two appraisals published in 1984 represent a landmark in describing glomerular disease within this group [2,3]. Other studies have shown various types of glomerular disturbances in HIV/AIDS patients, including: minimal change disease, mesangial proliferative, membranoproliferative, and membranous glomerulonephritis, IgA nephropathy, lupus-like glomerulonephritis, thrombotic microangiopathy, fibrillary glomerulonephritis and immunotactoid glomerulopathy [4][5][6][7][8][9][10]. The classical histological pattern associated with HIV is collapsing focal segmental glomerulosclerosis (collapsing FSGS).…”

mentioning

confidence: 99%

Prevalence of persistent proteinuria in stable HIV/AIDS patients and its association with HIV nephropathy

Cavalcante¹,

Coelho²,

Lacerda³

2007

Braz J Infect Dis

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Human immunodeficiency virus (HIV)-related glomerular disease is a cause of end-stage renal disease, though there is no recent data from Brazil concerning this syndrome. Persistent proteinuria (PPt) is the main marker for glomerular disease, especially levels above 1.5 g. We examined the prevalence of and associated risk factors for PPt, along with the prevalence of HIV-associated nephropathy (HIVAN) among AIDS patients. We interviewed 411 patients who were attended at the HIV/AIDS section of the Clinical Hospital of the Federal University of Pernambuco (Brazil) from January through June 2004. PPt was defined as a positive urine dipstick exam on at least two occasions. The analyzed risk factors were: black race, a low CD4 lymphocyte count (<200 cells/mm 3 ), an HIV RNA level of >100,000 copies/mL and patients on highly-active antiretroviral therapy (HAART). The patients were classified according to urinary protein/creatinine ratio (Up/Uc) < 1.0, 1.0-3.0 and > 3.0. Patients with Up/Uc >3.0 were submitted to renal biopsy. Among the 411 HIV/AIDS patients, the mean age was 37 years, 70% were male, 37.5% were black, the mean CD4 count was 363 cells/mm 3 (± 95), the mean RNA HIV count was 44,475 copies/mL (± 40,369), and 92% were on HAART. The prevalence of PPt was 5.6% (95% CI = 3.6 to 8.3%), and it was significantly associated with a low CD4 lymphocyte count (p<0.048). HIVAN was found in just one patient, and two patients improved after HAART.

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confidence: 99%

Prevalence of persistent proteinuria in stable HIV/AIDS patients and its association with HIV nephropathy

Cavalcante¹,

Coelho²,

Lacerda³

2007

Braz J Infect Dis

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“…All these drugs are used in cases of proven toxicity with other drugs. On the other hand, it has been noted previously that HIV/AIDS develops more rapidly in infected patients in blacks, playing a very crucial role in the low prevalence as well as delaying the development of renal disease before death of the patients [50,51]. However, our study subjects did not use any of these combinations and there was no adverse reaction reported by the subjects at the time of the study.…”

Section: Discussionmentioning

confidence: 66%

Assessment of Kidney Function, Estimated Glomerular Filtration Rate and Body Mass Index in Hiv Seropositive Subjects on Antiretroviral Therapy in Nnewi

Onwubuya

Ukibe

Kalu

et al. 2018

Int J Pharm Pharm Sci

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Objective: Antiretroviral therapy (ART) is anticipated to result in an increase in long-term survival in human immunodeficiency virus (HIV) infected individuals, but may present with the development of associated complications including kidney damage. The present study aimed at assessing the kidney function estimated glomerular filtration (eGFR) rate and body mass index (BMI) of HIV seropositive subjects with or without HAART at Nnewi, Nigeria. Methods:A total of 90 subjects were recruited comprising of 30 HIV-seropositive on highly antiretroviral therapy (HAART), 30 HIV-seropositive drug naive, and 30 HIV-seronegative (control subjects). Anthropometric parameters of the subjects were assessed using a well-structured questionnaire. Five millilitres of blood sample was collected from the patients and used for the estimation of urea, creatinine, uric acid, serum total protein and cluster of differentiation (CD4) T-cell counts using diacetyl monoxime method, Jaffe-slot method, Caraway phosphotungstic acid method, refractometry and flow cytometric method respectively.

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“…In fact, HIVAN is one of the most important causes of end-stage renal disease and chronic dialysis in some countries [8]. Some patients show an abrupt presentation, with advanced renal insufficiency already detected at the first examination [2]. Our patient presented massive proteinuria and hypoalbuminemia together with an advanced renal failure as the first manifestations of HIVAN [1,9].…”

Section: Discussionmentioning

confidence: 89%

“…Patients with this HIV-associated nephropathy (HIVAN) present with nephrotic syndrome and a rapidly progressing renal insufficiency. Endstage renal failure commonly develops within a few months after the onset of massive proteinuria [2,3]. Although there is no proven effective therapy for HIVAN, some studies have suggested that corticosteroids, angiotensin-converting enzyme inhibitors, and, more recently, antiretroviral therapy may have beneficial effects, retarding the progression of renal failure [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Improvement of the Renal Function in a Patient with HIV-Associated Focal Glomerulosclerosis

Morales

Martínez²,

Sánchez-Ayuso³

et al. 2002

Am J Nephrol

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Collapsing glomerulopathy is a pattern of renal injury that is seen in association with human immunodeficiency virus (HIV) infection. Patients with this HIV-associated nephropathy (HIVAN) present nephrotic syndrome and rapid deterioration of the renal function. There is no proven effective therapy for HIVAN, and the majority of the patients become dialysis dependent. We report a case of biopsy-proven HIVAN that showed spontaneous improvement of the renal function.

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Human Immunodeficiency Virus Associated Nephropathy (HIVAN)

Cited by 18 publications

References 9 publications

Prevalence of persistent proteinuria in stable HIV/AIDS patients and its association with HIV nephropathy

Prevalence of persistent proteinuria in stable HIV/AIDS patients and its association with HIV nephropathy

Assessment of Kidney Function, Estimated Glomerular Filtration Rate and Body Mass Index in Hiv Seropositive Subjects on Antiretroviral Therapy in Nnewi

Spontaneous Improvement of the Renal Function in a Patient with HIV-Associated Focal Glomerulosclerosis

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