Human Herpesvirus 8 in Italian HIV-Seronegative Patients With Kaposi Sarcoma

Cattani, Paola; Capuano, M.; Parola, Ilaria Lesnoni La; Guido, R. Fernandes; Santangelo, Rosaria; Cerimele, Francesca; Masini, Cinzia; Nanni, Giuseppe; Fadda, Giovanni; Cerimele, D

doi:10.1001/archderm.134.6.695

Cited by 42 publications

(36 citation statements)

References 43 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is similar to another study where 23% of the control group comprised of healthy volunteers and patients with various dermatological diseases from central and southern regions of Italy had HHV-8 DNA in their PBMCs 38 .…”

Section: Epidemiology Of Hhv-8 Infection -Serological Datasupporting

confidence: 90%

Human herpesvirus 8 (HHV-8) and the etiopathogenesis of Kaposi's sarcoma

Leão¹,

Caterino–de–Araujo

Porter

et al. 2002

Rev. Hosp. Clin.

View full text Add to dashboard Cite

OBJECTIVE: To review the current literature on human herpesvirus 8 with particular attention to the aspects related to the etiopathogenesis of Kaposi's sarcoma. MATERIALS AND METHODS: The authors searched original research and review articles on specific aspects of human herpesvirus 8 infection, including virology, epidemiology, transmission, diagnosis, natural history, therapy, and Kaposi's sarcoma etiopathogenesis. The relevant material was evaluated and reviewed. RESULTS: Human herpesvirus 8 is a recently discovered DNA virus that is present throughout the world but with major geographic variation. In the Western world, the virus, transmitted mainly by means of sexual contact, is strongly associated with Kaposi's sarcoma and body cavity-based lymphoma and more controversially with multiple myeloma and other non-proliferative disorders. There is no specific effective treatment, but HIV protease inhibitors may play an indirect role in the clearance of human herpesvirus 8 DNA from peripheral blood mononuclear cells of HIV-infected patients. Human herpesvirus 8 DNA is present in saliva, but there are as yet no documented cases of nosocomial transmission to health care workers. The prevalence of human herpesvirus 8 among health care workers is probably similar to that in the general population. CONCLUSION: Human herpesvirus 8 appears to be, at least in Western Europe and United States, restricted to a population at risk of developing Kaposi's sarcoma. Human herpesvirus 8 certainly has the means to overcome cellular control and immune responses and thus predispose carriers to malignancy, particularly Kaposi's sarcoma. The wide diffusion of Human herpesvirus 8 in classic Kaposi's sarcoma areas appears to represent an important factor in the high incidence of the disease. However, additional co-factors are likely to play a role in the development of Kaposi's sarcoma.

show abstract

Section: Epidemiology Of Hhv-8 Infection -Serological Datasupporting

confidence: 90%

Human herpesvirus 8 (HHV-8) and the etiopathogenesis of Kaposi's sarcoma

Leão¹,

Caterino–de–Araujo

Porter

et al. 2002

Rev. Hosp. Clin.

View full text Add to dashboard Cite

show abstract

“…This rate was statistically indistinguishable from the rate (14.9%) observed in controls. The observed rate of seropositivity in pretransplant patients was higher than rates reported in other European countries (8,19) and can be explained by the higher-thanaverage HHV-8 seroprevalence in the general population of central and southern Italy (5,14,22,23). The data suggest that HHV-8 seroprevalence is unaffected by pretransplant therapeutic regimens.…”

Section: Discussionmentioning

confidence: 52%

“…HHV-8 has been detected in virtually all KS patients. Viral DNA and serum antibodies to HHV-8 appear to have predictive value for the onset of KS, especially in patients with compromised immune systems (2,5,7,20).…”

mentioning

confidence: 99%

Kaposi's Sarcoma Associated with Previous Human Herpesvirus 8 Infection in Kidney Transplant Recipients

et al. 2001

Self Cite

View full text Add to dashboard Cite

This study investigates the prevalence of human herpesvirus 8 (HHV-8) infection in kidney transplant patients, evaluating the risk of HHV-8 transmission via transplantation and the association between pre-and posttransplantation HHV-8 infection and the subsequent development of Kaposi's sarcoma (KS). Immunofluorescence and an enzyme immunoassay were used to determine HHV-8 seroprevalence in 175 patients awaiting kidney transplantation and 215 controls who were attending our clinic for other reasons. All patients in the study came from central or southern Italy. Seroprevalence was similar in both groups (14.8 versus 14.9%), with no significant difference between the rates for male and female patients. Of the 175 patients, 100 were tested for anti-HHV-8 antibodies at various times during follow-up. During follow-up, seroprevalence increased from 12% on the date of transplantation to 26%. This increase was paralleled by an age-related increase in seroprevalence in the control group. During follow-up from 3 months to 10 years after transplantation, KS was diagnosed in seven patients (4.0%). Six of these patients were positive for HHV-8 prior to transplantation. Overall, 23.0% of patients who were HHV-8 positive before transplantation developed KS, whereas only 0.7% of seronegative patients developed the disease (relative risk, 34.4; 95% confidence interval, 4.31 to 274.0). This finding suggests that the key risk factor for KS is infection prior to transplantation and that antibody detection in patients awaiting transplantation could be useful in identifying patients at high risk for KS. In patients from geographic areas with a high prevalence of HHV-8, serological tests on donors may be less important.

show abstract

“…HHV-8 DNA was detected in 100% of the lesional specimens and in 69.6% of the PBMCs in HIV seronegative patients with KS. Moreover, it was not always detectable in the PBMCs among the same patients at different times (4). Here, we report three cases of KS that developed after patients underwent immunosuppressive therapies and had HHV-8 DNA both in their tumors and PBMCs.…”

Section: Introductionmentioning

confidence: 87%

“…Since 1979, there have been numerous cases of iatrogenic KS reported in patients treated with immunosuppressive agents for organ transplantations and those with autoimmune disorders or malignant neoplasms (1). HHV-8 DNA was first found in tissues obtained from patients with AIDS but has since been identified in all four clinical forms of KS (2)(3)(4). HHV-8 DNA was detected in 100% of the lesional specimens and in 69.6% of the PBMCs in HIV seronegative patients with KS.…”

Section: Introductionmentioning

confidence: 99%

Three cases of HHV-8 DNA found in patients with iatrogenic Kaposi�s sarcoma

Ishii-Osai¹

2015

cderm

View full text Add to dashboard Cite

SummaryCases of Kaposi's sarcoma (KS) have been previously reported in patients treated with immunosuppressive agents. We report here three cases of KS in immunosuppressed patients with nephrotic syndrome, erythema elevatum diutinum and bullous pemphigoid (BP). One patient died due to the rapid progression of KS and in two patients there was a complete regression or considerable improvement after reduction or withdrawal of corticosteroids and radiation treatment. Human herpes virus 8 (HHV-8) DNA was detected from the tumor specimen and peripheral blood mononuclear cells (PBMCs) in all three patients.

show abstract

Human Herpesvirus 8 in Italian HIV-Seronegative Patients With Kaposi Sarcoma

Cited by 42 publications

References 43 publications

Human herpesvirus 8 (HHV-8) and the etiopathogenesis of Kaposi's sarcoma

Human herpesvirus 8 (HHV-8) and the etiopathogenesis of Kaposi's sarcoma

Kaposi's Sarcoma Associated with Previous Human Herpesvirus 8 Infection in Kidney Transplant Recipients

Three cases of HHV-8 DNA found in patients with iatrogenic Kaposi�s sarcoma

Contact Info

Product

Resources

About