1998
DOI: 10.1001/archderm.134.6.695
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Human Herpesvirus 8 in Italian HIV-Seronegative Patients With Kaposi Sarcoma

Abstract: To evaluate the prevalence of human herpesvirus 8 (HHV-8) DNA detection in a large series of human immunodeficiency virus-seronegative patients with and without Kaposi sarcoma (KS) from the central and southern regions of Italy where classic KS is prevalent. Design: Samples of lesional, peripheral unaffected, and distant normal skin and peripheral blood mononuclear cells (PBMCs) from 33 patients with KS and PBMCs from 42 control subjects were analyzed using single and nested polymerase chain reaction technique… Show more

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Cited by 42 publications
(36 citation statements)
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“…This is similar to another study where 23% of the control group comprised of healthy volunteers and patients with various dermatological diseases from central and southern regions of Italy had HHV-8 DNA in their PBMCs 38 .…”
Section: Epidemiology Of Hhv-8 Infection -Serological Datasupporting
confidence: 90%
“…This is similar to another study where 23% of the control group comprised of healthy volunteers and patients with various dermatological diseases from central and southern regions of Italy had HHV-8 DNA in their PBMCs 38 .…”
Section: Epidemiology Of Hhv-8 Infection -Serological Datasupporting
confidence: 90%
“…This rate was statistically indistinguishable from the rate (14.9%) observed in controls. The observed rate of seropositivity in pretransplant patients was higher than rates reported in other European countries (8,19) and can be explained by the higher-thanaverage HHV-8 seroprevalence in the general population of central and southern Italy (5,14,22,23). The data suggest that HHV-8 seroprevalence is unaffected by pretransplant therapeutic regimens.…”
Section: Discussionmentioning
confidence: 52%
“…HHV-8 has been detected in virtually all KS patients. Viral DNA and serum antibodies to HHV-8 appear to have predictive value for the onset of KS, especially in patients with compromised immune systems (2,5,7,20).…”
mentioning
confidence: 99%
“…HHV-8 DNA was detected in 100% of the lesional specimens and in 69.6% of the PBMCs in HIV seronegative patients with KS. Moreover, it was not always detectable in the PBMCs among the same patients at different times (4). Here, we report three cases of KS that developed after patients underwent immunosuppressive therapies and had HHV-8 DNA both in their tumors and PBMCs.…”
Section: Introductionmentioning
confidence: 87%
“…Since 1979, there have been numerous cases of iatrogenic KS reported in patients treated with immunosuppressive agents for organ transplantations and those with autoimmune disorders or malignant neoplasms (1). HHV-8 DNA was first found in tissues obtained from patients with AIDS but has since been identified in all four clinical forms of KS (2)(3)(4). HHV-8 DNA was detected in 100% of the lesional specimens and in 69.6% of the PBMCs in HIV seronegative patients with KS.…”
Section: Introductionmentioning
confidence: 99%