Human herpesvirus 6A and 6B and NK cells

Rizzo, Roberta; Luca, Dario Di

doi:10.1556/030.65.2018.010

Cited by 9 publications

(9 citation statements)

References 31 publications

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“…We first reported HHV-6A DNA presence in 43% of endometrial cells from women with idiopathic infertility, whereas no fertile control women harbored the virus 1 . Growing evidence confirms this implication [1][2][3][4][5][6] . We investigated the effect of HHV-6A infection on the immunological status of the endometrium.…”

Section: Objectivementioning

confidence: 96%

Endometrium infection by human herpesvirus-6A: implication in female idiopathic infertility

Rizzo

Luca

2018

Fertility and Sterility

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OBJECTIVE: A possible association between allergy and infertility has not been investigated. Our aim was to determine whether female allergy correlates with infertility treatment outcomes. DESIGN: Retrospective cohort study in an academic medical center. MATERIALS AND METHODS: Patient data from July 2010 through January 2017 was compiled from medical records. Mixed effects models were used to evaluate the relationship between presence of female allergy and type (fresh or FET) and cycle outcomes, controlling for type of procedure, number of embryos transferred, female patient age, BMI, smoking status, gravidity, parity, and Caucasian race. RESULTS: After exclusions for missing data, the cohort contained 493 patients with a total of 935 cycles. Of these, 90.7% identified as Caucasian with a mean age of 34.8 (SD¼4.6) at the time of each cycle initiation. Over half of the female patients had allergy (54.0%). Nonexclusively, among all female patients, allergy to antibiotics was most common (29.2%), followed by allergy to non-antibiotic prescription medications (22.3%). Allergies to pollen and dust (5.7%), foods (6.5%), latex (4.4%) and other substances (9.7%) including cat and dog allergens were less common. Among cycles with fresh embryo transfer (581 cycles from 408 patients), having an allergy to pollen and/or dust was significantly associated with having a negative beta-hCG test (p¼0.02). Pollen/dust allergy was not associated with SAB, biochemical pregnancy, or ectopic pregnancy alone; however, it was associated with whether an infant was born at the end of the cycle (p¼0.04), with only 15.4% of those with a pollen/dust allergy having a cycle which resulted in a live-born infant compared with 34.7% of those without such allergy. Overall, the presence of any allergy was not associated with negative beta-hCG or pregnancy outcomes, nor was other sub-classes of allergies. CONCLUSIONS: The high rates of allergy among patients seeking infertility treatment, as compared to the general population, are surprising. Female allergy to pollen and/or dust is associated with a greater chance of failed fertility treatment and a lower chance of a successful pregnancy resulting in a live-born infant. The reproductive performance of allergic patients needs further investigation using a larger dataset.

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Section: Objectivementioning

confidence: 96%

Endometrium infection by human herpesvirus-6A: implication in female idiopathic infertility

Rizzo

Luca

2018

Fertility and Sterility

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“…In a pregnant woman, in contrast, NK cells are less prone to attack “foreign” antigens. When NK cell receptors recognize human leucocyte antigen-E (HLA-E) and HLA-G antigens on cytotrophoblasts, the NK cells do not attack cells containing paternal antigens, facilitating implantation ( 48 ). Theoretically, HHV-6A/B infection of NK cells could disrupt the down-regulation of the NK cell attack on cytotrophoblasts, contributing to defective implantation and to the pathogenesis of both primary unexplained infertility and PE.…”

Section: Hhv-6a/b In Reproductive Organsmentioning

confidence: 99%

“…HHV-6A infection of the endometrium reduces levels of two decidualization markers, soluble human leucocyte antigen-G (sHLA-G) and mucin1 ( 48 , 57 ), possibly augmenting the maternal immune response against paternally-derived fetal antigens ( 56 ). Infection of endometrial epithelial cells also generates a pattern of microRNA expression that has been linked to implantation failure ( 35 ).…”

Section: Primary Unexplained Infertilitymentioning

confidence: 99%

Human Herpesviruses 6A and 6B in Reproductive Diseases

2021

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Human herpesviruses 6A (HHV-6A) and human herpesvirus 6B (HHV-6B)—collectively, HHV-6A/B—are recently-discovered but ancient human viruses. The vast majority of people acquire one or both viruses, typically very early in life, producing an ineradicable lifelong infection. The viruses have been linked to several neurological, pulmonary and hematological diseases. In early human history, the viruses on multiple occasions infected a germ cell, and integrated their DNA into a human chromosome. As a result, about 1% of humans are born with the full viral genome present in every cell, with uncertain consequences for health. HHV-6A may play a role in 43% of cases of primary unexplained infertility. Both the inherited and acquired viruses may occasionally trigger several of the factors that are important in the pathogenesis of preeclampsia. Transplacental infection occurs in 1-2% of pregnancies, with some evidence suggesting adverse health consequences for the child. While emerging knowledge about these viruses in reproductive diseases is not sufficient to suggest any changes in current practice, we write this review to indicate the need for further research that could prove practice-changing.

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“…OBJECTIVE: We first reported HHV-6A DNA presence in 43% of endometrial cells from women with idiopathic infertility, whereas no fertile control women harbored the virus 1 . Growing evidence confirms this implication [1][2][3][4][5][6] . We investigated the effect of HHV-6A infection on the immunological status of the endometrium.…”

mentioning

confidence: 96%

“…OBJECTIVE: Patients with significantly elevated or diminished BMI may exhibit a variety of health consequences and decreased fecundity. The reproductive impact of elevated BMI has been well studied, but few studies have convincingly quantified the effects of low BMI on oocyte/embryo quality and implantation efficacy [1][2][3][4][5][6] . This study aimed to determine the impact of low BMI on ovarian response to controlled ovarian stimulation (COS) for IVF.…”

mentioning

confidence: 99%

High prevalence of allergy in patients undergoing assisted reproductive technology: a conundrum

Esfandiari

Cruz

Litzky

et al. 2018

Fertility and Sterility

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Patients in all BMI groups had similar gravidity, parity, and cycle characteristics, including endometrial thickness, percent of embryos biopsied for preimplantation genetic testing for aneuploidy (PGT-A), day of embryo biopsy, and blastocyst morphology. CP rate did not differ among BMI groups. There were also no differences in OP/LB (p¼0.78), EPL (p¼0.37), and CPL rates (p¼0.88) among BMI groups, before and after adjusting for confounders.CONCLUSIONS: While the maternal metabolic environment adversely affects IVF outcomes in obese women, the mechanism of action is not fully understood. Following transfer of a single, frozen blastocyst in OD cycles, overweight and obese patients had similar CP, OP/LB, EPL, and CPL rates compared to controls. This study is the first to evaluate the impact of obesity on implantation, independent of oocyte quality, and confirms that maternal obesity exhibits minimal effect on the endometrium. Future studies of the endometrial transcriptome and metabolome may improve our understanding of the impact of nutritional status and obesity on endometrial receptivity.

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Human herpesvirus 6A and 6B and NK cells

Cited by 9 publications

References 31 publications

Endometrium infection by human herpesvirus-6A: implication in female idiopathic infertility

Endometrium infection by human herpesvirus-6A: implication in female idiopathic infertility

Human Herpesviruses 6A and 6B in Reproductive Diseases

High prevalence of allergy in patients undergoing assisted reproductive technology: a conundrum

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