Human Herpesvirus 6: The Virus and The Search for Its Role as a Human Pathogen

Pellett, Philip E.; Black, Jodi B.; Yamamoto, Masahiro

doi:10.1016/s0065-3527(08)60034-2

Cited by 80 publications

(35 citation statements)

References 205 publications

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“…HHV-6, another member of the herpesvirus family, has been detected in semen (60), and is causally associated with exanthema subitum (89), acute febrile diseases and seizures in young children (90,91), and EBV-and CMV-negative cases of mononucleosis in young adults (92,93). In this study, HHV-6 DNA was detected in 3.8% of semen samples, and often occurred in high copy numbers (up to 81,000,000).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

218

167

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Objective-To determine the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers and other semen variables.Design-Retrospective, controlled study. Results-STI DNA was detected in 45/241 (18.7%) of the samples (CMV 8.7%, HPV 4.5%, HHV-6 3.7%, HSV 3.7%, CT 2.5%, EBV 0.4%, and HBV 0%), with no difference in prevalence between LCS and non-LCS groups. STI DNA in semen was associated with a decrease in sperm concentration, motile sperm concentration, total sperm count and neutral α-glucosidase concentration, whereas LCS was associated with a decrease in total sperm count, % normal forms and fructose concentration. Setting-CenterReprint requests: Deborah J. Anderson, Ph.D., Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany Street, Suite 516, Boston, MA 02118, (FAX: 617-414-8481; e-mail: E-mail: deborah.anderson@bmc.org). Capsule: Sexually transmissible pathogens were detected in 19% of semen samples from infertility patients seeking routine semen analyses; their presence was not associated with leukocytospermia, but was associated with reduced semen quality.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusion(s)-STI pathogen DNA was detected in semen from a high percentage of asymptomatic male infertility patients and was associated with poor semen quality. Efforts to diagnose and treat subclinical genital tract infections should be intensified. NIH Public Access

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Section: Discussionmentioning

confidence: 99%

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

218

167

View full text Add to dashboard Cite

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“…Both infect T lymphocytes, and can be reactivated in vitro from peripheral blood mononuclear cells (PBMCs), probably as a result of reactivation from a latent state (Kondo et al, 1991;Pellett et al, 1992;Frenkel et aL, 1992). The HHV-6 strains have been subdivided into two clusters, designated as variants A and B, differing in the restriction endonuclease cleavage pattern of the viral DNAs, growth in continuous cell lines, reactivity to a few monoclonal antibodies (MAbs) and extent of DNA homology (Ablashi et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

“…Subsequent isolates were derived from PBMCs of healthy individuals , of a patient with chronic fatigue syndrome (Berneman et al, 1992b), and from the saliva of normal adults (Black et al, 1993;. Both HHV-6 and -7 are highly prevalent among humans (Clark et al, 1993;Pellett et al, 1992;Wyatt et al, 1991). Both HHV-6 and -7 are shed in the saliva (Black et al, 1993;Cone et aL, 1993;Frenke| & Wyatt, 1992).…”

Section: Introductionmentioning

confidence: 99%

Polyvalent and monoclonal antibodies identify major immunogenic proteins specific for human herpesvirus 7-infected cells and have weak cross-reactivity with human herpesvirus 6

Foà-Tomasi

Avitabile²,

Liu³

et al. 1994

Journal of General Virology

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“…Subsequently, viruses similar to Z29 were derived from cases of exanthem subitum and shown to be the causative agents of the disease (Yamanishi et al, 1988). Additional isolates were obtained from a number of pathological conditions as well as from healthy individuals (Pellett et al, 1992). The U1102, GS and Z29 strains show cross-reactivity, a genome with an overlapping structure, identical base composition and size, and extensive cross-hybridization (Pellett et al, 1992).…”

mentioning

confidence: 99%

“…Additional isolates were obtained from a number of pathological conditions as well as from healthy individuals (Pellett et al, 1992). The U1102, GS and Z29 strains show cross-reactivity, a genome with an overlapping structure, identical base composition and size, and extensive cross-hybridization (Pellett et al, 1992). The genomes of U1102 and GS and that of Z29 were found early to differ with respect to a HindIII restriction endonuclease site (Becker et al, 1989;Jarret et al, 1989;Josephs et al, 1988) located in a fragment hybridizing to the pZVH14 probe (Josephs et al, 1986).…”

mentioning

confidence: 99%

Monoclonal antibodies to glycoprotein B differentiate human herpesvirus 6 into two clusters, variants A and B

Campadelli-Fiume

Guerrini

Liu

et al. 1993

Journal of General Virology

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The distribution of glycoprotein B (gB) among different human herpesvirus 6 (HHV-6) strains was analysed with a panel of three monoclonal antibodies (MAbs) derived from mice immunized with U1102-infected lymphocytes. MAb 2D9 reacted specifically by immunofluorescence and immunoprecipitation with the Ul102 and GS isolates, and failed to react with Z29 and the variant B strains Hashimoto and SF. In addition, Z29, Hashimoto and SF gB had a lower M r than U1102 and GS gB. MAb 2D9 also failed to react with the exanthem subitum isolate CV, included in this study as an as yet poorly characterized isolate. Consistent with this result, CV failed to react with the variant A-specific MAb to gp82-105 and behaved as a variant B virus even with respect to the diagnostic HindIII endonuclease restriction cleavage site located in a fragment hybridizing to the pZVHI4 probe. By contrast with MAb 2D9, MAbs 2B9 and 2D10 reacted with all of the isolates tested, strengthening the argument that they have common epitopes. Based on the antigenic and M r specificities of gB, the HHV-6 isolates tested were arranged into two non-overlapping clusters, which closely parallel the variant A and B strain groups, defined previously by several criteria, including restriction endonuclease polymorphism, antigenic variations, growth in in vitro cultures and sequence analyses.

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Human Herpesvirus 6: The Virus and The Search for Its Role as a Human Pathogen

Cited by 80 publications

References 205 publications

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Polyvalent and monoclonal antibodies identify major immunogenic proteins specific for human herpesvirus 7-infected cells and have weak cross-reactivity with human herpesvirus 6

Monoclonal antibodies to glycoprotein B differentiate human herpesvirus 6 into two clusters, variants A and B

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