Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways

Shi, Lei; Peng, Nanfang; Xie, Jiajia; Hao, Qian; Zhang, Mo; Zhang, Yi; Xia, Zhangchuan; Xu, Gang; Zhao, Fanpeng; Wang, Qing; Han, Tao; Zhu, Ying

doi:10.1016/j.jhep.2014.11.035

Cited by 55 publications

(77 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, many of these vaccines are directed against viral structures involved in malignant transformation (Table 2). This advantage can be exploited, because the vaccine can deliver antigen and stimulate robust effector T cell responses, whereas the natural infection is subject to the myriad intricate immune evasion and immunosuppression mechanisms these viruses have developed in the course of evolution (92)(93)(94)(95)(96)(97)(98). Nevertheless, these vaccines have to work against the same peripheral cell tolerance-, anergy-, and suppression-driving mechanisms operating in nononcogenic, persistent viral infections and nonviral cancers.…”

Section: Clinical Cancer Vaccines Against Nonviral Antigensmentioning

confidence: 99%

Therapeutic cancer vaccines

Melief

Hall

Arens

et al. 2015

Journal of Clinical Investigation

685

378

View full text Add to dashboard Cite

Conflict of interest: Cornelis J.M. Melief is fully employed as Chief Scientific Officer of ISA Pharmaceuticals and has stock appreciation rights in the company. Cornelis Melief and Sjoerd H. van der Burg are co-inventors on numerous patents and patent applications in the area of synthetic long peptide vaccines. Clinical trials conducted by Melief and van der Burg with synthetic long peptides have been funded by the Dutch Cancer Society and by ISA Pharmaceuticals.

show abstract

Section: Clinical Cancer Vaccines Against Nonviral Antigensmentioning

confidence: 99%

Therapeutic cancer vaccines

Melief

Hall

Arens

et al. 2015

Journal of Clinical Investigation

685

378

View full text Add to dashboard Cite

show abstract

“…Similarly, Siva et al (51) demonstrated that the upregulation of MVP is not sufficient to confer an MDR phenotype. In addition, recent studies have correlated MVP with several signaling pathways (52)(53)(54)(55)(56) and immune responses (57)(58)(59)(60), which imply that the function of MVP may be more complex than expected. Thirdly, the inability to find an association between variants of the MVP gene and platinum resistance or survival in the present study may be due to the limited number of patients enrolled in the study, since the number of patients in the subgroup was below the statistical threshold.…”

Section: Discussionmentioning

confidence: 99%

Association of single nucleotide polymorphisms in the MVP gene with platinum resistance and survival in patients with epithelial ovarian cancer

Wang

2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. The human major vault protein (MVP) has been linked to the development of multidrug resistance in cancer cells, and overexpression of MVP has been observed in ovarian cancer tissues. The aim of the present study was to investigate the association between single nucleotide polymorphisms (SNPs) in the MVP gene and the tumor response to platinum-based chemotherapy and survival of patients affected by epithelial ovarian cancer (EOC), in addition to confirm whether tetra-primer amplification-refractory mutation system (ARMS)-polymerase chain reaction (PCR) is an accurate genotyping method. For this purpose, two polymorphisms in the MVP gene, namely reference SNP (rs)1057451 and rs4788186, were selected from the data obtained by the International haplotype map (HapMap) Project regarding Chinese Han population, and were evaluated by tetra-primer ARMS-PCR. Upon validation by DNA sequencing, the association of these polymorphisms with platinum resistance, progression-free survival (PFS) and overall survival (OS) in patients with EOC was assessed. The results of tetra-primer ARMS-PCR were in agreement with those derived from DNA sequencing. No significant differences were observed between platinum-sensitive and platinum-resistant cohorts in terms of allele and genotype distribution of these two polymorphisms in the MVP gene, which were not associated with PFS or OS. However, a trend toward prolonged PFS was observed in patients carrying the heterozygous AG allele at the rs4788186 locus. These results suggest that rs1057451 and rs4788186 variants in the MVP gene are not associated with favorable therapeutic response to platinum or longer survival in Chinese Han patients affected by EOC. In addition, the data of the present study confirm that tetra-primer ARMS-PCR is a trustworthy and economical genotyping method.

show abstract

“…The human enterovirus 71 (EV71) strain (GenBank accession No. JN230523.1) and hepatitis B virus (HBV) expression plasmid pHBV-1.3 (genotype D, serotype ayw, U95551) were reported previously [31,32] .…”

Section: Cell Culture and Virusmentioning

confidence: 99%

Inducible GBP5 Mediates the Antiviral Response via Interferon-Related Pathways during Influenza A Virus Infection

et al. 2017

Self Cite

View full text Add to dashboard Cite

Guanylate binding protein (GBP) 5 belongs to the GBP family, which is involved in important cellular processes, including signal transduction, translation, vesicle trafficking, and exocytosis. Structurally, GBPs display a high degree of homology and share highly conserved GTP-binding or hydrolysis domains. GBP5 was reported to be a critical cellular factor in inflammasome assembly. However, little is known about its role in the host antiviral innate immune response. In this study, we found that GBP5 expression was significantly elevated in influenza patients and influenza A virus-infected A549 human lung epithelial cells. The overexpression of GBP5 inhibited virus replication by enhancing the expression of virus-induced interferon (IFN) and IFN-related effectors. Knockdown of GBP5 had the opposite effect. Moreover, GBP5 enhanced endogenous IFN expression by interacting with the NF-κB-essential modulator complex and stimulating NF-κB signaling. Additionally, the expression of proinflammatory factors, such as IL-6, IL-8, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase, was also activated by GBP5. Taken together, our results reveal that GBP5 inhibited virus replication through the activation of IFN signaling and proinflammatory factors.

show abstract

Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways

Cited by 55 publications

References 38 publications

Therapeutic cancer vaccines

Therapeutic cancer vaccines

Association of single nucleotide polymorphisms in the MVP gene with platinum resistance and survival in patients with epithelial ovarian cancer

Inducible GBP5 Mediates the Antiviral Response via Interferon-Related Pathways during Influenza A Virus Infection

Contact Info

Product

Resources

About