Human heart-type fatty-acid-binding protein as a point-of-care test in the early diagnosis of acute myocardial infarction

Abstract

Although h-FABP can help to detect myocardial damage at an early stage in patients with chest pain or dyspnoea, it appears unsuitable as a stand-alone test for ruling out AMI.

Biomarkers of Atherosclerosis and Acute Coronary Syndromes - A Clinical Perspective

“…Five studies have investigated the diagnostic utility of H-FABP when used for the diagnosis of AMI at the time of presentation to the ED (234)(235)(236)(237)(238). Four of these studies utilised qualitative assays that are available as point of care tests.…”

Heart-Type Fatty Acid Binding Protein Is an Independent Predictor of Death and Ventricular Dysfunction After Coronary Artery Bypass Graft Surgery

“…27 A point-of-care test that uses hFABP has been developed for the diagnosis of MI in nonsurgical patients with purportedly superior sensitivity and specificity than cTnI. [28][29][30] A point-of-care test for the perioperative setting has the potential to have an effect on timeefficient risk stratification and management after cardiac surgery. Earliest identification of patients with clinically relevant myocardial injury could enable clinicians to identify patients in need of further diagnostic or therapeutic procedures to reduce loss of myocardial mass or performance.…”

Troponin T and Heart Type Fatty Acid Binding Protein (h-Fabp) as Biomarkers in Patients Presenting with Chest Pain

“…It can be used for prognosis in chronic heart failure patients [11], and also to detect myocardial damage within 1 h after onset of ischemia [12]. However, the clinical impact of this on its diagnostic performance remains uncertain [13]. This study aims to validate the immunoturbidimetric quantitative in vitro determination of h-FABP and to compare its levels to routinely measured Troponin T levels in early diagnosis of patient presenting with acute chest pain in emergency department in a tertiary care hospital.…”