Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistance

Ashbolt, Nicholas J.; Amézquita, Aléjandro; Backhaus, Thomas; Borriello, Peter; Brandt, Kristian K.; Collignon, Peter; Coors, Anja; Finley, Rita; Gaze, William H.; Heberer, Thomas; Lawrence, John R.; Larsson, D. G. Joakim; McEwen, Scott A.; Ryan, James J.; Schönfeld, Jens; Silley, P.; Snape, Jason; Eede, Christel Van den; Topp, Edward

doi:10.1289/ehp.1206316

Cited by 540 publications

(336 citation statements)

References 89 publications

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“…As a route of transmission the extent of human exposure to antibiotic resistant bacteria from the natural environment is not fully understood and is likely to be an underestimated phenomenon (Ashbolt et al, 2013;Finley et al, 2013;Heuer et al, 2011;Wellington et al, 2013). Anthropogenic activities that lead to the introduction of human / animal associated bacteria or antibiotics into the environment may, for example, allow for the exchange and selection of resistance genes between the environmental resistome and clinically important pathogens.…”

Section: Introductionmentioning

confidence: 99%

Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons

Cleary

Bishop

Zhang

et al. 2016

FEMS Microbiology Ecology

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Kornelia. (2016) Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons. FEMS Microbiology Ecology, 92 (10). fiw159. Permanent WRAP URL:http://wrap.warwick.ac.uk/84355 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Publisher's statement:This is a pre-copyedited, author-produced PDF of an article accepted for publication in FEMS Microbiology Ecology following peer review. The version of record (see above) is available online at http://dx.doi.org/10.1093/femsec/fiw159 A note on versions: The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. Cyanobacteria, was shown to increase in abundance significantly; a curiosity given the established sensitivity of this Class to antibiotics. We hypothesise that the overrepresentation of Proteobacteria as OTUs that decreased significantly in relative abundance, coupled with the observations of an increase in integron prevalence, may represent a strong selective pressure on these taxa.

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Section: Introductionmentioning

confidence: 99%

Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons

Cleary

Bishop

Zhang

et al. 2016

FEMS Microbiology Ecology

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“…As a serious concern, the environmental reservoirs are a source of emergence and transfer of ARGs from environmental to introduced bacteria into those pathogenic to humans and animals [26,27]. Consequently, the environmental contamination by antibiotic resistance is potentially associated with impacts on human and animal health.…”

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confidence: 99%

What are the effective solutions to control the dissemination of antibiotic resistance in the environment? A systematic review protocol

et al. 2018

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Background: Antibiotic treatments are indispensable for human and animal health. However, the heavy usage of antibiotics has led to the emergence of resistance. Antibiotic residues, antibiotic-resistant bacteria and genes are introduced into the terrestrial and aquatic environments via application of human and animal wastes. The emergence and the spread of antibiotic resistance in environmental reservoirs (i.e., soil, water, wildlife) threatens the efficacy of all antibiotics. Therefore, there is an urgent need to determine what effective solutions exist to minimize the dissemination of antibiotic resistance in the environment. The aim of this article is to describe the protocol of a systematic review of the literature considering these solutions. Methods:The primary questions addressed by the systematic review protocol are: how antibiotic resistance in the environment is impacted by changes in practice concerning (i) the use of antibiotics, (ii) the management of wastes or (iii) the management of the natural compartment. Bibliographic searches will be made in eleven publication databases as well as in specialist databases. Grey literature will also be searched. Articles will be screened regarding the inclusion and exclusion criteria at title, abstract and full-text levels. Studies where a causal relationship between the intervention and the outcome is made will be retained. After critical appraisal, data from the selected articles will be extracted and saved in a database validated by the expert panel. Study quality will be assessed by critical appraisal. Data will be compiled into a qualitative synthesis. If data availability and quality allow it, a quantitative synthesis will be carried out.

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“…However, there are biologically plausible indications that contaminated raw water, wastewater and other environmental determinants may be playing an important role in the development and spread of AMR. It is unclear, the extent to which countries are conducting risk assessments to identify risks and management goals, which can guide the development of environmental management options, with clear indicators of effectiveness [29]. The assessment of the environmental risks is however not straight forward, as naturally occurring resistance genes can be present in the environment [12,29].…”

Section: Antimicrobial Resistance and The Water Sanitation And Hygiementioning

confidence: 99%

“…The application of animal waste (biosolids) to agricultural soils (as soil conditioner) is commonly practised in the United States, Europe and Australia [47], and this acts as an entry point of both antibiotics and genetic resistance determinants into the environment [7,29,48]. Enteric bacteria can remain persistent in the environment for weeks to months, depending on species and temperature.…”

Section: Soil-borne Resistancementioning

confidence: 99%

“…The lack of quantitative data has been identified by several sources as a key factor hindering appropriate AMR surveillance efforts. While the assessment of the environmental risks is not straight forward, inter-agency and inter-jurisdictional risk assessments could help to identify risks and management goals with clear indicators of effectiveness, to aid the development of environmental management options [12,29]. Ashbolt and colleagues (2013) postulated that in addition to traditional risk assessment methods various novel aspects must be considered in the assessment of environmental antibiotic resistance.…”

Section: Tackling the Problemmentioning

confidence: 99%

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Understanding the contribution of environmental factors in the spread of antimicrobial resistance

Fletcher-Lartey

2015

Environ Health Prev Med

195

131

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The overuse and abuse of antibiotics have contributed to the global epidemic of antibiotic resistance. Current evidence suggests that widespread dependency on antibiotics and complex interactions between human health, animal husbandry and veterinary medicine, have contributed to the propagation and spread of resistant organisms. The lack of information on pathogens of major public health importance, limited surveillance, and paucity of standards for a harmonised and coordinated approach, further complicates the issue. Despite the widespread nature of antimicrobial resistance, limited focus has been placed on the role of environmental factors in propagating resistance. There are limited studies that examine the role of the environment, specifically water, sanitation and hygiene factors that contribute to the development of resistant pathogens. Understanding these elements is necessary to identify any modifiable interactions to reduce or interrupt the spread of resistance from the environment into clinical settings. This paper discusses some environmental issues that contribute to antimicrobial resistance, including soil related factors, animal husbandry and waste management, potable and wastewater, and food safety, with examples drawn mainly from the Asian region. The discussion concludes that some of the common issues are often overlooked and whilst there are numerous opportunities for environmental factors to contribute to the growing burden of antimicrobial resistance, a renewed focus on innovative and traditional environmental approaches is needed to tackle the problem.

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Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistance

Cited by 540 publications

References 89 publications

Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons

Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons

What are the effective solutions to control the dissemination of antibiotic resistance in the environment? A systematic review protocol

Understanding the contribution of environmental factors in the spread of antimicrobial resistance

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