What are the effective solutions to control the dissemination of antibiotic resistance in the environment? A systematic review protocol

Goulas, Anais; Livoreil, Barbara; Grall, Nathalie; Benoît, Pierre; Couderc-Obert, Céline; Dagot, Christophe; Patureau, Dominique; Petit, Fabienne; Laouénan, Cédric; Andremont, Antoine

doi:10.1186/s13750-018-0118-2

Cited by 25 publications

(24 citation statements)

References 30 publications

(37 reference statements)

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“…This systematic review was conducted according to the guidelines for systematic reviews of the Collaboration for Environmental Evidence [22] (https ://envir onmen talev idenc ejour nal.biome dcent ral.com/submi ssion -guide lines ) and to the materials and methods detailed in the openaccess systematic review protocol [20]. We also followed the RepOrting standards for Systematic Evidence Syntheses (ROSES, Additional file 1) [23].…”

Section: Methodsmentioning

confidence: 99%

“…The main objectives of this review were: (1) to identify Interventions and (2) to assess their effectiveness to reduce the dissemination of ATBR in the environment. According to our protocol [20], three sub-questions were identified as pathways to reduce ATBR dissemination in the environment (Table 1). Population, Intervention or Exposure, Comparator components are specific to each sub-question, while Outcomes are the same for the three sub-questions (PICO/PECO in Table 2).…”

Section: Objectives Of the Reviewmentioning

confidence: 99%

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How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review

et al. 2020

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Background: Antibiotic resistance is a major concern for public and environmental health. The role played by the environment in disseminating resistance is increasingly considered, as well as its capacity for mitigation. We reviewed the literature on strategies to control dissemination of antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARG) and mobile genetic elements (MGE) in the environment. Methods: This systematic review focused on three main strategies: (i) restriction of antibiotic use (S1), (ii) treatments of liquid/solid matrices (S2) and (iii) management of natural environment (S3). Articles were collected from seven scientific databases until July 2017 and from Web of Science until June 2018. Only studies reporting measurements of ARB, ARG or MGE in environmental samples were included. An evidence map was drawn from metadata extracted from all studies eligible for S1, S2 and S3. Subsets of studies were assessed for internal and external validity to perform narrative and quantitative syntheses. A meta-analysis was carried out to assess the effects of organic waste treatments (random-effect models). Review findings: Nine hundred and thirty-one articles representing 1316 individual studies (n) were eligible for S1 (n = 59), S2 (n = 781) and S3 (n = 476) strategies, respectively. Effects of interventions to control the dissemination of antibiotic resistance in the environment were primarily studied in strategy S2. A partial efficiency of wastewater treatment plants (WWTPs) to reduce antibiotic resistance in treated effluent was reported in 118 high validity studies. In spite of the heterogeneity in published results, the meta-analysis showed that composting and drying were efficient treatments to reduce the relative abundance of ARG and MGE in organic waste, by 84% [65%; 93%] and 98% [80%; 100%], respectively. The effect of anaerobic digestion was not statistically significant (51% reduction [− 2%; 77%]) when organic waste treatments were compared together in the same model. Studies in strategies S1 and S3 mainly assessed the effects of exposure to sources of contamination. For instance, 28 medium/high validity studies showed an increase of antibiotic resistance in aquatic environments at the WWTP discharge point. Some of these studies also showed a decrease of resistance as the distance from the WWTP increases, related to a natural resilience capacity of aquatic environments. Concerning wildlife, nine medium/high validity studies showed that animals exposed to anthropogenic activities carried more ARB.

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Section: Methodsmentioning

confidence: 99%

Section: Objectives Of the Reviewmentioning

confidence: 99%

How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review

et al. 2020

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“…The abuse of antimicrobials in human and veterinary medicine often leads to proliferation of ARB and ARGs that can be transferred to human pathogenic bacteria. This transfer eventually nulli es the e cacy of current and upcoming antibiotics, thereby leading to treatment failure for some life-threatening diseases [45,46]. The impact of AMR leading to antibiotic-resistant infections suggests that close to a million people die annually and further projections of 10 million people could die globally by the year 2050 due to these infections [47].…”

Section: Isolation and Antimicrobial Susceptibility Testingmentioning

confidence: 99%

“…Globally, due to the speedy emergence and spread of resistant bacteria and associated antimicrobial resistant genes amongst human populations, animals and the environment, there is an urgent need to achieve optimum state of health in these biomes as necessitated by the One Health strategy through concerted effort of national, regional and global bodies. The strategy involves a multi-sectoral approach of combating the crisis through the alliance of FAO, OIE and WHO [13][14][15]. The apprehension with respect to antibiotic use is justi ed because of the close relation between antibiotics used in both human medicine and animal production, which has resulted in cross-species transmission of ARB and ARG from the environment and animals to humans [16].…”

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confidence: 99%

Antibiotic resistant gene of Pseudomonas aeruginosa from non-clinical environment: public health implications in Mthatha, Eastern Cape Province, South Africa

Hosu¹,

Vasaikar²,

Okuthe³

et al. 2020

Preprint

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Background Pseudomonas aeruginosa (P. aeruginosa) are Gram-negative bacilli that are ubiquitous in nature particularly plentiful in soils and in aquatic milieu because they thrive well in humid or wet environments. It has extensive metabolic versatility, ability to thrive well and colonize diverse ecological habitats such as soil, rhizosphere, wastewaters that, enhances its potential threat to public health. Abattoirs, aquatic ecosystem including generated wastewaters are latent sources of pathogenic bacteria, serve as reservoirs and contribute to the spread of antibiotic resistant genes. Several studies have focused on clinical environment while scarce data exist from non-clinical environments, which sometimes are hotspots of antibiotic resistance. Thus, the present investigation aimed to identify antibiotic resistant gene of P. aeruginosa from non-clinical sources in Mthatha, Eastern Cape and evaluate its public health implications. Results Fifty-five (55) Pseudomonas species and other organisms recovered from effluent and surface water samples included P. aeruginosa (65.4%), P. fluorescens (27.3%), Burkholderia gladioli (5.5%) and Burkholderia cepacia (1.8%). The P. aeruginosa isolates showed high resistance to aztreonam (86.1%), ceftazidime (63.9%), piperacillin (58.3%) and cefepime (55.6%); with moderate resistance displayed to imipenem (50%), piperacillin/tazobactam (47.2%), meropenem (41.7%) and levofloxacin (30.6%). Twenty out of thirty-six (36) P. aeruginosa displayed multidrug resistance profiles and were classified as multidrug resistant (MDR) (55.6%). Most of the bacterial isolates exhibited a high Multiple Antibiotic Resistance (MAR) Index of > 0.2 ranging from 0.08–0.69 with a mean MAR Index of 0.38. PCR analysis of fifteen (15) P. aeruginosa isolates detected 14 (93.3%) harbored blaSHV, 6 (40%) harbored blaTEM with the least occurring ESBL as blaCTX−M at 3 (20%). Conclusions Results of the current study indicating resistance of environmental P. aeruginosa isolates to front-line clinically relevant antipseudomonal drugs is concerning and poses risk to the environment and receiving water bodies. Given the public health relevance, the results of this study highlight the importance and urgent need of monitoring multidrug-resistant pathogens in effluent environments. These non-clinical environments are potential reservoirs of resistance genes that would further serve as avenues for the dissemination of multidrug resistant bacteria in the community.

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“…The global consumption of antibiotics was reported to increase by 36% from 2000 to 2010 (4). However, the increased use of antibiotics has led to the accumulation of antibiotics in the environment in recent years (5). During the fermentation process for antibiotic production, some residual antibiotics are discharged into water (6).…”

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Isolation and Characterization of Ochrobactrum tritici for Penicillin V Potassium Degradation

Wang

Shen

et al. 2020

mSphere

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Substantial concentrations of penicillin V potassium (PVK) have been found in livestock manure, soil, and wastewater effluents, which may pose potential threats to human health and contribute to the emergence of penicillin-resistant bacterial strains. In this study, bacterial strains capable of degrading PVK were isolated from sludge and characterized. Strain X-2 was selected for biodegradation of PVK. Based on morphological observations and 16S rRNA gene sequencing, strain X-2 was identified as an Ochrobactrum tritici strain. To enhance the PVK degradation ability of PVK, a whole-cell biodegradation process of Ochrobactrum tritici X-2 was established and optimized. In the whole-cell biodegradation process, the optimal temperature and pH were 30°C and 7.0, respectively. Under the optimized conditions, the degradation rate using 0.5 mg/ml PVK reached 100% within 3 h. During biodegradation, two major metabolites were detected: penicilloic acid and phenolic acid. The present study provides a novel method for the biodegradation of PVK using Ochrobactrum tritici strains, which represent promising candidates for the industrial biodegradation of PVK. IMPORTANCE Substantial concentrations of penicillin V potassium (PVK) have been found in the environment, which may pose potential threats to human health and contribute to the emergence of penicillin-resistant bacterial strains. In this study, antibiotic-degrading bacterial strains for PVK were isolated from sludge and characterized. Ochrobactrum tritici was selected for the biodegradation of PVK with high efficiency. To enhance its PVK degradation ability, a whole-cell biodegradation process was established and optimized using Ochrobactrum tritici. The degradation rate with 0.5 mg/ml PVK reached 100% within 3 h. The potential biodegradation pathway was also investigated. To the best of our knowledge, the present study provides new insights into the biodegradation of PVK using an Ochrobactrum tritici strain, a promising candidate strain for the industrial biodegradation of β-lactam antibiotics.

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What are the effective solutions to control the dissemination of antibiotic resistance in the environment? A systematic review protocol

Cited by 25 publications

References 30 publications

How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review

How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review

Antibiotic resistant gene of Pseudomonas aeruginosa from non-clinical environment: public health implications in Mthatha, Eastern Cape Province, South Africa

Isolation and Characterization of Ochrobactrum tritici for Penicillin V Potassium Degradation

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