Human Health Effects of Lactose Consumption as a Food and Drug Ingredient

Seoane, Rafael G; García-Recio, Verónica; Garrosa, Manuel; Ma, Rojo; Jiménez, Pilar; Girbés, Tomás; Córdoba-Díaz, Manuel; Córdoba-Díaz, Damián

doi:10.2174/1381612826666200212114843

Cited by 8 publications

(3 citation statements)

References 64 publications

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“…The term LI refers to the emergence of GI symptoms particularly bloating, abdominal cramps, diarrhea, vomiting, and nausea after the consumption of lactoserich food items (6,25,26) (Figure 1). The deficiency of β-galactosidase is also known as hypolactasia, which results in an inefficient breakdown of lactose and leads to lactose maldigestion (LM).…”

Section: Lactose Intolerancementioning

confidence: 99%

Intolerance to Milk Lactose, Diagnostic Tests and Dietary Management: A Recent Update

Shafi

Husain

2022

Avicenna J Med Biochem

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Lactose intolerance is a common pathology that occurs due to the reduced activity of β-galactosidase leaving undigested lactose in the intestine. About 70% of the world population suffers from this condition. The gastro intestinal symptoms associated with this condition are diarrhoea, pain, nausea, bloating, flatulence, etc. It has been reported that these individuals are at a risk of developing several other pathologies like irritable bowel disease, osteoporosis, etc. Hence, proper diagnosis and treatment is essential for dealing with this condition. Various methods are used for providing an accurate diagnosis, such as hydrogen breath test (HBT), lactose intolerance test, genetic test, intestinal biopsy, etc. Depending on the type of intolerance, several methods are adopted for treating it, such as replacing enzyme, using exogenous enzymes, following lactose free diet, as well as consuming prebiotics and probiotics. Different methods are applied to synthesize lactose free dairy products to help lactose intolerant individuals suffering from important vitamins and minerals deprivation. Recently, plant-based milks are also used as a substitute for providing calcium and vitamins. The last few years have seen improvement in the quality and availability of lactose-free dairy products offering tempting foodstuffs to consumers. This narrative article aimed to review the existing science on lactose intolerance, along with its epidemiology, diagnosis, and clinical management.

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Section: Lactose Intolerancementioning

confidence: 99%

Intolerance to Milk Lactose, Diagnostic Tests and Dietary Management: A Recent Update

Shafi

Husain

2022

Avicenna J Med Biochem

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“…After this phase, they should receive complementary foods as they continue to be breastfed, at least until the age of two [6,[17][18][19]. However, in some situations, breastfeeding is not possible or advisable due to issues related to the mother's health [20][21][22] or due to the baby's health [23]. For these cases, international scientific medical societies recommend that when all strategies for maintaining breastfeeding are exhausted, the infant milk formulas should be used [20,24].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds in Infant Formula and Their Effects on Infant Nutrition and Health: A Systematic Literature Review

Almeida

Pereira

Leandro

et al. 2021

International Journal of Food Science

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Infant formulas are an alternative to replace or supplement human milk when breastfeeding is not possible. The knowledge of human milk’s bioactive compounds and their beneficial effects has attracted the interest of researchers in the field of infant nutrition, as well as researchers of technology and food sciences that seek to improve the nutritional characteristics of infant formulas. Several scientific studies evaluate the optimization of infant formula composition. The bioactive compound inclusion has been used to upgrade the quality and nutrition of infant formulas. In this context, the purpose of this systematic literature review is to assess the scientific evidence of bioactive compounds present in infant formulas (α-lactalbumin, lactoferrin, taurine, milk fat globule membrane, folates, polyamines, long-chain polyunsaturated fatty acids, prebiotics, and probiotics) and their effects on infant nutrition and health. Through previously determined criteria, studies published in the last fifteen years from five different databases were included to identify the advances in the optimization of infant formula composition. Over the last few years, there has been optimization of the infant formula composition, not only to increase the similarities in their content of macro and micronutrients but also to include novel bioactive ingredients with potential health benefits for infants. Although the infant food industry has advanced in the last years, there is no consensus on whether novel bioactive ingredients added to infant formulas have the same functional effects as the compounds found in human milk. Thus, further studies about the impact of bioactive compounds in infant nutrition are fundamental to infant health.

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“…Whereas the supply of lactose-rich ingredients has been growing because of the production of and demand for higher protein dairy ingredients (MPC, WPC, and WPI), the demand for high-lactose ingredients has not kept up. Though the clinical condition lactose intolerance is not common (~10% of the population), varying degrees of lactose maldigestion and malabsorption are common (~66% of the population) worldwide ( Oak and Jha, 2019 ; Seoane et al, 2020 ; Jansson-Knodell et al, 2022 ). Additionally, some consumers wrongly associate symptoms of a variety of intestinal disorders with lactose intolerance, without undergoing testing, and therefore unnecessarily avoid dairy foods ( Suchy et al, 2010 ).…”

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confidence: 99%