Human Gut Microbiome Response to Short-Term Bifidobacterium-Based Probiotic Treatment

Naumova, Natalia; Alikina, Tatiana; Tupikin, Alexey E.; Калмыкова, А. И.; Солдатова, Г. С.; Vlassov, Valentin V.; Kabilov, Мarsel R.

doi:10.1007/s12088-020-00888-1

Cited by 17 publications

(19 citation statements)

References 23 publications

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“…Their biological effects on constipation remain unclear; however, several studies reported that the increase in these bacteria is positively related to improved constipation. Negativicutes were increased by Psyllium Husk (derived from seeds of Plantago ovata ) administration 27 and Bifidobacterium -based probiotic treatment 28 during constipation improvement. Acidaminococcus may be one of the main factors in curing constipation during faecal microbial transplantation in clinical application 29 and administration of partially hydrolyzed guar gum (water-soluble fibres) in children 30 .…”

Section: Discussionmentioning

confidence: 99%

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

Terasawa

Okazaki

Nakayama

et al. 2021

Sci Rep

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Rhamnan sulphate (RS), a sulphated polysaccharide from Monostroma nitidum, possesses several biological properties that help in treating diseases such as viral infection, thrombosis, and obesity. In the present study, we first administered RS (0.25 mg/g food volume) orally to high-fat diet-treated mice for 4 weeks. RS increased the faecal volume and calorie excretion with decreased plasma lipids, which was in accordance with the results of our previous zebrafish study. Notably, as the excretion amount by RS increased in the mice, we hypothesised that RS could decrease the chance of constipation in mice and also in human subjects because RS is considered as a dietary fibre. We administrated RS (100 mg/day) to subjects with low defaecation frequencies (3–5 times/week) for 2 weeks in double-blind placebo-controlled manner. As a result, RS administration significantly increased the frequency of dejection without any side effects, although no effect was observed on the body weight and blood lipids. Moreover, we performed 16s rRNA-seq analysis of the gut microbiota in these subjects. Metagenomics profiling using PICRUSt revealed functional alternation of the KEGG pathways, which could be involved in the therapeutic effect of RS for constipation.

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Section: Discussionmentioning

confidence: 99%

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

Terasawa

Okazaki

Nakayama

et al. 2021

Sci Rep

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“…In addition to a decline in the physical health of individuals due to ingestion of improper food, the effect of quarantine in deteriorating the mental health, especially in children, was also observed [53]. Herein, we would like to point out that such a condition may be avoided if the person is accustomed to healthy diet or diet supplemented with healthy microbes such as probiotics [54,55]. Disturbances at the gut-brain axis, occurring due to various gastro-intestinal conditions, have been implicated in various mental health abnormalities as well such as anxiety, mood disorders and depression [56].…”

Section: Effect Of Microbiota On Covid-19 Cases During Lockdownmentioning

confidence: 99%

Diet, Gut Microbiota and COVID-19

et al. 2020

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Worldwide, millions of individuals have been affected by the prevailing SARS-CoV-2. Therefore, a robust immune system remains indispensable, as an immunocompromised host status has proven to be fatal. In the absence of any specific antiviral drug/vaccine, COVID-19 related drug repurposing along with various other nonpharmacological measures coupled with lockdown have been employed to combat this infection. In this context, a plant based rich fiber diet, which happens to be consumed by a majority of the Indian population, appears to be advantageous, as it replenishes the host gut microbiota with beneficial microbes thereby leading to a symbiotic association conferring various health benefits to the host including enhanced immunity. Further, implementation of the lockdown which has proven to be a good non-pharmacological measure, seems to have resulted in consumption of home cooked healthy diet, thereby enriching the beneficial microflora in the gut, which might have resulted in better prognosis of COVID-19 patients in India in comparison to that observed in the western countries.

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“…Commonly studied depression and anxiety are shown to associate with diseases including irritable bowel disease (IBS) and also obesity, although the causal relationships are still difficult to establish 33 . In both cases, gut microbial dybiosis was described to be one of the contributing factors, and even used as therapeutical target by approaches including probiotic treatment and fecal material transplantation 34,35 . While in general population, the mental well-being is also established to be closely related to gut microbial contributions, in particular their potential of producing neuro-active substances 36 .…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome Couples Gut and Brain During Calorie Restriction in Treating Obesity

Zeng

Wang

Xiang

et al. 2021

Preprint

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Background: Calorie restriction (CR) has been widely recognized for its effect in reducing body weight and alleviating diabetes in humans, as well as prolonging life span in animal studies. Gut microbiome shifts contribute to part of the effects of CR, but little is known regarding their influences except on metabolism and immunity.Methods: We combined the human population-based (metagenomic, metatranscriptomics shotgun sequencing data) and mice-based approaches to revealed microbial determinants that could contribute to successful weight loss.Results: Microbiome changes are linked to changes in blood metabolome and hormones, which eventually correlate to brain functional changes as studied using functional magnetic resonance imaging (fMRI). Brain functional shifts indicate response of central neural system (CNS) to CR, and microbiome constitutes thekeystone of gut-brain axis. Animal experiment further reaffirms the gut microbiome changes, metabolic and hormonal shifts of CR, while proteomic analysis of brain tissues suggest that epigenetic modifications of key proteins could explain responses of CNS to CR.Conclusion: Our study establishes linkage between CR, gut microbiome, metabolome/ hormones and CNS function, and demonstrates that CR has multi-facet, coordinated effects on the host, of which many could contribute to weight loss and other beneficial effects.

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Human Gut Microbiome Response to Short-Term Bifidobacterium-Based Probiotic Treatment

Cited by 17 publications

References 23 publications

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

Diet, Gut Microbiota and COVID-19

Gut Microbiome Couples Gut and Brain During Calorie Restriction in Treating Obesity

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Human Gut Microbiome Response to Short-Term Bifidobacterium-Based Probiotic Treatment

Cited by 17 publications

References 23 publications

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

Diet, Gut Microbiota and COVID-19

Gut&nbsp;Microbiome Couples Gut and Brain During Calorie Restriction in Treating Obesity

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Product

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Gut Microbiome Couples Gut and Brain During Calorie Restriction in Treating Obesity