Abstract:Background: Calorie restriction (CR) has been widely recognized for its effect in reducing body weight and alleviating diabetes in humans, as well as prolonging life span in animal studies. Gut microbiome shifts contribute to part of the effects of CR, but little is known regarding their influences except on metabolism and immunity.Methods: We combined the human population-based (metagenomic, metatranscriptomics shotgun sequencing data) and mice-based approaches to revealed microbial determinants that could co… Show more
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