Human Growth Hormone

Frantz, Andrew G.; Rabkin, Mitchell T.

doi:10.1056/nejm196412312712701

Cited by 276 publications

(20 citation statements)

References 16 publications

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“…Plasma HGH values in the control subjects during the intravenous insulin tolerance test are similar to those reported by other workers (8,9). Patients with diabetes secondary to severe chronic pancreatitis were by no means totally deficient in HGH reserve; nevertheless, in comparison with the control responses, a significant impairment emerged.…”

Section: Discussionsupporting

confidence: 87%

Growth Hormone Response to Insulin-Induced Hypoglycemia in Diabetes Secondary to Chronic Calcific Pancreatitis

Vinik¹,

Joffe²,

Joubert³

et al. 1970

The Journal of Clinical Endocrinology & Metabolism

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Human growth hormone (HGH) responses to insulin-induced hypoglycemia were measured in 6 patients with diabetes secondary to chronic calcific pancreatitis (pancreatic diabetes). A group of carefully matched control • subjects was similarly investigated. Despite induced hypoglycemia of a magnitude not significantly different from the controls at 30 min, and significantly greater at 45 and 60 min, patients with pancreatic diabetes responded with significantly impaired peak HGH levels. The interpretation of these findings is uncertain, although the observation that children with cystic fibrosis of the pancreas show similarly blunted responses suggests that a pancreatic stimulus to HGH secretion may be lacking. (J Clin Endocr 31: 86, 1970) ABNORMAL sensitivity to exogenously ad-JLJL ministered insulin has been demonstrated in patients who develop diabetes secondary to chronic pancreatitis (pancreatic diabetes) (1). Pancreatic glucagon insufficiency may be partly responsible, and preliminary data of Aguilar Parada and associates (2) tend to support this hypothesis. However, as insulin sensitivity can occur in human growth hormone (HGH) deficiency, it was of interest to measure the HGH responses during insulin-induced hypoglycemia in pancreatic diabetes. Materials and MethodsSix lean patients (5 males and 1 female) with well-proven chronic pancreatic disease-all showing radiologically demonstrable pancreatic calcification-were studied. Chronic alcoholism was considered to have been an etiological factor in all cases. Despite this, biochemical evidence of hepatic dysfunction was uniformly absent. No patient was hypoalbuminemic or uremic and there was no known family history of diabetes. The mean age of the patients was 57 yr (range 50-64 yr). All had diabetic glucose tolerance curves (3)-although, except in one instance, the fasting blood sugar was normal. None had previously received insulin therapy (2, taking oral sulfonylurea drugs, were instructed to discontinue them before testing). No patient showed ketosis or admitted to recent heavy consumption of alcohol. None were taking drugs known to suppress the HGH response to insulin hypoglycemia (4, 5).

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Section: Discussionsupporting

confidence: 87%

Growth Hormone Response to Insulin-Induced Hypoglycemia in Diabetes Secondary to Chronic Calcific Pancreatitis

Vinik¹,

Joffe²,

Joubert³

et al. 1970

The Journal of Clinical Endocrinology & Metabolism

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“…1969). The difference between these and previous studies (Frantz and Rabkin, 1964;Hartog et al, 1964) probably lies in the higher doses of steroids given to adults by the earlier investigators, though children also have shown some impairment of growth hormone release when given daily prednisone in doses of 7-5 mg. and above (Friedman and Greenwood, 1968). The results in our two patients who had repeat tests agree with the contention that a negative growth hormone response to a single adequate test stimulus does not permit a diagnosis of growth hormone deficiency (Raiti et al, 1967;Martin et al, 1968).…”

Section: Discussioncontrasting

confidence: 54%

Cortisol and Growth Hormone Secretion in Relation to Linear Growth: Patients with Still's Disease on Different Therapeutic Regimens

Sturge¹,

Beardwell²,

Hartog³

et al. 1970

BMJ

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“…The initial application of radioimmunoassay techniques to the study of circulating GH concentrations in man unexpectedly revealed acute and major increases in plasma levels during insulin hypoglycemia (3,19,(21)(22)(23) and exercise (3,21,24,25), as well as smaller and more variable elevations in response to prolonged fasting (3). The studies by Hunter and his colleagues (26,27), however, did not reveal consistent correlations between food intake and GH levels in the normal intervals between regular meals.…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone Secretion in the Unanesthetized Rhesus Monkey in Response to Noxious Stimuli¹

1967

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Serial blood samples, taken from conscious, lightly restrained rhesus monkeys bearing indwelling venous catheters or chronically implanted intracardiac catheters, were assayed for growth hormone (GH) concentration by a radioimmunologic procedure. It was found that sudden perturbations in the environment and painful stimuli were associated with abrupt increases in plasma GH levels. Hemorrhage as well as the administration of histamine, epinephrine, chlorpromazine and, on occasion, of pentobarbital led to precipitous elevations in plasma GH concentration. Arousal from pentobarbital anesthesia was accompanied by marked increases in circulating GH levels. These findings coupled with earlier observations that large doses of vasopressin also cause rapid increases in plasma GH concentration lead to the conclusion that a variety of otherwise unrelated stimuli, all known to augment ACTH secretion, similarly activate the release of GH from the pituitary. {Endocrinol-ogy 80:163,1967)

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Human Growth Hormone

Cited by 276 publications

References 16 publications

Growth Hormone Response to Insulin-Induced Hypoglycemia in Diabetes Secondary to Chronic Calcific Pancreatitis

Growth Hormone Response to Insulin-Induced Hypoglycemia in Diabetes Secondary to Chronic Calcific Pancreatitis

Cortisol and Growth Hormone Secretion in Relation to Linear Growth: Patients with Still's Disease on Different Therapeutic Regimens

Growth Hormone Secretion in the Unanesthetized Rhesus Monkey in Response to Noxious Stimuli¹

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Human Growth Hormone

Cited by 276 publications

References 16 publications

Growth Hormone Response to Insulin-Induced Hypoglycemia in Diabetes Secondary to Chronic Calcific Pancreatitis

Growth Hormone Response to Insulin-Induced Hypoglycemia in Diabetes Secondary to Chronic Calcific Pancreatitis

Cortisol and Growth Hormone Secretion in Relation to Linear Growth: Patients with Still's Disease on Different Therapeutic Regimens

Growth Hormone Secretion in the Unanesthetized Rhesus Monkey in Response to Noxious Stimuli1

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Growth Hormone Secretion in the Unanesthetized Rhesus Monkey in Response to Noxious Stimuli¹