Cortisol and Growth Hormone Secretion in Relation to Linear Growth: Patients with Still's Disease on Different Therapeutic Regimens

Sturge, R. A.; Beardwell, Colin G; Hartog, M.; Wright, Donald R.; Ansell, Barbara M.

doi:10.1136/bmj.3.5722.547

Cited by 47 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Clinical studies have shown that a greater anabolic response to hGH is achieved by single injection if the treatment is given at the time of the nadir of cortisol concentration, rather than at the time of the peak (Rudman et al 1973). Antagonism of the anabolic effects of GH in children by administration of high doses of gluco¬ corticoids has been demonstrated by several workers (Soyka & Crawford, 1965;Morris et al 1968;Sturge, Beardwell, Hartog et al 1970). However, the present study lends little support to the hypothesis that physiological concentrations of glucocorticoids may counteract the anabolic effects of pGH in rats.…”

Section: Discussioncontrasting

confidence: 73%

Changes in serum concentrations of ACTH, corticosterone and in growth following morning or evening injection of female rats with porcine growth hormone

Sillence

Etherton

1989

Journal of Endocrinology

View full text Add to dashboard Cite

The present study was designed to examine the effects of stress, associated with daily handling and placebo injection, on growth and adrenal activity in female rats. A second objective was to examine the effects of porcine GH (pGH) on growth and on serum concentrations of ACTH and corticosterone. Treatments were administered in the morning (08.00 h) in semi-darkness, or in the evening (20.00 h) towards the end of the light period and were timed to coincide with reported periods of high and low adrenal sensitivity to ACTH. Handling of and s.c. injection of saline into female rats (initial body weight 220 g) each morning for 21 days did not affect growth, food intake or organ weights. In contrast, daily handling and saline injection each evening caused a marked reduction in weight gain (25%), food intake (12%) and liver weight (8%), accompanied by a trend towards an increase in adrenal weight (11%), but no change in serum corticosterone concentrations. In a second experiment, treatment of female rats (initial body weight 180 g) with pGH (5.6 mg/kg) daily at 08.00 h caused a significant improvement in weight gain (17%), but food intake and organ weights were unaltered. Daily injection of rats with pGH at 20.00 h caused a greater relative improvement in weight gain (45%) than did treatment at 08.00 h as the growth impairment caused by the stress of handling was counteracted. The adverse effect of evening injections of saline on food intake was also counteracted by pGH. Changes in liver and adrenal weights, however, were not attenuated by pGH treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussioncontrasting

confidence: 73%

Changes in serum concentrations of ACTH, corticosterone and in growth following morning or evening injection of female rats with porcine growth hormone

Sillence

Etherton

1989

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Suppression of the hypothalamic pituitary adrenal axis, as judged by basal plasma cortisol level and insulin tolerance test, after long-term low dosage corticosteroid therapy, does occur in Still's disease (Sturge et al, 1970) and the addition of ACTH to the corticosteroid regimen failed to preserve or restore a normal hypothalamic pituitary adrenal axis function in our patients. This agrees with the findings in adults (Carter and James, 1970a), Friedman and Greenwood (1968) have reported that long-term ACTH therapy in children does not suppress the hypothalamic pituitary adrenal axis to the same extent as corticosteroid treatment.…”

Section: Discussionmentioning

confidence: 55%

Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth

Zutshi¹,

Friedman²,

Ansell³

1971

Archives of Disease in Childhood

Self Cite

View full text Add to dashboard Cite

“…On a daily regimen, this would give 35 mg/m 2 per week. With alternate-day therapy, growth retardation is less likely to occur [12,27]. Only two of our patients had daily therapy with weekly doses of 35 mg/m 2 or more at the beginning of hGH therapy.…”

Section: Discussionmentioning

confidence: 92%

“…Kuhns and Swaim [19] also observed disturbance of growth in children affected by rheumatoid arthritis. The introduction of glucocorticoids in the long-term treatment of this disease added a further cause of growth failure [22,27]. Stinger [24,25] found that 146 children from a total of 872 patients suffering from rheumatoid arthritis or Still's disease had severe growth retardation: 118 of these suffered from complete or incomplete Still's disease and only 28 from rheumatoid arthritis without systemic involvement.…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid arthritis and growth retardation in children: Treatment with human growth hormone

Butenandt

1979

Eur J Pediatr

View full text Add to dashboard Cite

Twenty patients with rheumatoid arthritis or Still's disease associated with growth failure were treated with human growth hormone, 7.5 to 17 U/m2 body surface per week. Five patients did not respond with better growth. In the remainder the mean growth rate increased from 1.9 cm/year (range: 0 to 3.3) to 6.2 cm/year (range: 3.6 to 12) over 5 to 7 months. Twelve patients treated for longer periods increased their mean growth rate from 2.6 cm/year (range: 0.7 to 5.7) to 6.3 cm/year (range: 2.4 to 9.7) and continued to grow during a second year of treatment. Growth velocity decreased in 6 patients when the hGH therapy was discontinued. The causes for this improvement in growth are possibly multifactorial: the growth rate is depressed by the severity of the disease and high-dose glucocorticoid therapy. Increases of growth rate occurred during improvements in the disease, reduction of steroid medication, as a result of therapy with human growth hormone, and because of puberty in some patients. Human growth hormone seemed to improve the underlying condition of four of the patients but had no influence on the disease in the remaining children.

show abstract

Cortisol and Growth Hormone Secretion in Relation to Linear Growth: Patients with Still's Disease on Different Therapeutic Regimens

Cited by 47 publications

References 29 publications

Changes in serum concentrations of ACTH, corticosterone and in growth following morning or evening injection of female rats with porcine growth hormone

Changes in serum concentrations of ACTH, corticosterone and in growth following morning or evening injection of female rats with porcine growth hormone

Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth

Rheumatoid arthritis and growth retardation in children: Treatment with human growth hormone

Contact Info

Product

Resources

About