Human gastric hyperinfection by Anisakis simplex : A severe and unusual presentation and a brief review

Baptista-Fernandes, Teresa; Rodrigues, Manuel; Castro, Isabel; Paixão, Paulo; Pinto-Marques, Pedro; Roque, Lidia; Belo, Silvana; Ferreira, Pedro; Kamal, Mehnaz; Toscano, Cristina

doi:10.1016/j.ijid.2017.08.012

Cited by 39 publications

(23 citation statements)

References 7 publications

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“…According to the quantitative risk assessment model, the prevalence of anisakiosis in Europe will increase to 7500-8500 cases per year 17 . Anisakiosis is also an economic problem for fisheries due to the negative impact on consumer confidence resulting decrease in demand on the market for potentially parasitized fish species 10,18,19 . Based on Scientific opinion of the European Food Safety Authority (EFSA) 16 , there are not Anisakis free zone, thus the European Union (EU) promulgated rules (Regulations 853/2004, 1276/2011) to control this risk 20 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Proteome profiling of L3 and L4 Anisakis simplex development stages by TMT-based quantitative proteomics

Stryiński

Mateos

Pascual

et al. 2019

Journal of Proteomics

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Section: Accepted Manuscriptmentioning

confidence: 99%

Proteome profiling of L3 and L4 Anisakis simplex development stages by TMT-based quantitative proteomics

Stryiński

Mateos

Pascual

et al. 2019

Journal of Proteomics

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“…In humans, L3 Anisakis larvae are either unable to molt to the subsequent stage (L4) and reach reproductive maturity or molting to L4 occurs extremely rarely ( 7 ). However, in the course of infection, patients can suffer significant clinical symptoms ( 8 ). The estimated frequency of anisakiasis in Japan is approximately 2000 cases/year and in South Korea 200 cases/year, while for some European countries estimates range from 20 ( 9 ) to 500 cases/year ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular and Cellular Response to Experimental Anisakis pegreffii (Nematoda, Anisakidae) Third-Stage Larval Infection in Rats

et al. 2018

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Background: Anisakiasis is a zoonotic disease caused by accidental ingestion of live Anisakis spp. third-stage larvae present in raw or undercooked seafood. Symptoms of this emerging infectious disease include mild-to-severe abdominal pain, nausea, and diarrhea. Some patients experience significant allergic reactions.Aims: In order to better understand the onset of anisakiasis, we aimed to: (i) histopathologically describe severe inflammatory/hemorrhagic infection site lesions in Sprague-Dawley rats experimentally infected with Anisakis pegreffii larvae; and (ii) qualitatively and quantitatively characterize the transcriptomes of affected tissues using RNA-Seq.Methodology: The experiment was performed on 35 male rats, sacrificed at 5 time points (6, 10, 18, 24, and 32 h post-infection). Gastric intubation was performed with 10 A. pegreffii larvae (N = 5 infected rats per time point) or 1.5 ml of saline (external control N = 2 rats). 16 pools, seven for muscle tissues and nine for stomach tissues, were created to obtain robust samples for estimation of gene expression changes depicting common signatures of affected versus unaffected tissues. Illumina NextSeq 500 was used for paired-end sequencing, while edgeR was used for count data and differential expression analyses.Results: In total, there were 1372 (855 up and 517 down) differentially expressed (DE) genes in the Anisakis-infected rat stomach tissues, and 1633 (1230 up and 403 down) DE genes in the muscle tissues. Elicited strong local proinflammatory reaction seems to favor the activation of the interleukin 17 signaling pathway and the development of the T helper 17-type response. The number of DE ribosomal genes in the Anisakis-infected stomach tissue suggests that A. pegreffii larvae might induce ribosomal stress in the early infection stage. However, the downstream pathways and post-infection responses require further study. Histopathology revealed severe inflammatory/hemorrhagic lesions caused by Anisakis infection in the rat stomach and muscle tissues in the first 32 h. The lesion sites showed infiltration by polymorphonuclear leukocytes (predominantly neutrophils and occasional eosinophils), and to a lesser extent, macrophages.Conclusion: Understanding the cellular and molecular mechanisms underlying host responses to Anisakis infection is important to elucidate many aspects of the onset of anisakiasis, a disease of growing public health concern.

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“…Anisakiasis is a foodborne disease caused by the accidental ingestion of larval nematodes belonging to the family Anisakidae [ 1 , 2 ]. Incidence of anisakiasis, at one time relatively common only in East Asia due to the consumption of raw fish, have increased worldwide with the growing popularity of the seafood delicacy [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A case of hepatic anisakiasis caused by Pseudoterranova decipiens mimicking metastatic liver cancer

et al. 2018

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BackgroundAnisakid nematodes (Anisakis spp. or Pseudoterranova spp.) usually infect gastric or intestinal walls, while they rarely infect in extra-gastrointestinal sites of human body. Generally, Anisakis spp. larvae are highly infected in fish intermediate hosts, whereas Pseudoterranova spp. larvae are very rarely infected. To the best of our knowledge, there have been no reports which have documented cases of hepatic anisakiasis caused by Pseudoterranova spp. This report describes the first documented case of hepatic anisakiasis due to infection with Pseudoterranova decipiens and clinical features of the hepatic anisakiasis through literature review.Case presentationThe case was a 28-year-old man with prior history of malignancy who was found to have a hepatic mass mimicking metastatic liver tumor. A new low density area of 20 mm in diameter in liver segment 7 was found on follow-up CT. With suspicious diagnosis of metastatic liver cancer, laparoscopic partial hepatectomy was performed. A pathological examination revealed no evidence of malignancy, but showed necrotic granuloma with eosinophil infiltration and the presence of a larva with Y-shaped lateral cords, which are specific to anisakid larvae. The type of larva was identified as Pseudoterranova decipiens sensu lato using PCR of DNA purified from a fixed granuloma embedded in paraffin.ConclusionThe present report is the first to discuss the case of a patient with hepatic anisakiasis caused by Pseudoterranova decipiens. Hepatic anisakiasis is a potential differential diagnosis for hepatic tumors and genetic identification with the PCR method was reliable for obtaining final diagnosis even when the larvae body in the resected specimen collapses with time.

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Human gastric hyperinfection by Anisakis simplex : A severe and unusual presentation and a brief review

Cited by 39 publications

References 7 publications

Proteome profiling of L3 and L4 Anisakis simplex development stages by TMT-based quantitative proteomics

Proteome profiling of L3 and L4 Anisakis simplex development stages by TMT-based quantitative proteomics

Molecular and Cellular Response to Experimental Anisakis pegreffii (Nematoda, Anisakidae) Third-Stage Larval Infection in Rats

A case of hepatic anisakiasis caused by Pseudoterranova decipiens mimicking metastatic liver cancer

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