Human gastric atony with tachygastria and gastric retention

Telander, Robert L.; Morgan, Kathleen G.; Kreulen, David L.; Schmalz, P. F.; Kelly, Keith A.; Szurszewski, Joseph H.

doi:10.1016/0016-5085(78)90857-0

Cited by 194 publications

(54 citation statements)

References 10 publications

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“…The gastric slow wave originating from the proximal stomach and propagating distally, determines the maximum frequency and propagation of gastric contractions. Numerous studies have shown that disturbances in the gastric slow wave are associated with impaired gastric motility (8)(9)(10)(11)(12). Tachygastria (abnormal gastric slow waves with a frequency of higher than 4 cycles/min) has been consistently shown to cause hypomotility of the stomach (12)(13)(14).…”

mentioning

confidence: 99%

Retrograde Gastric Pacing Reduces Food Intake and Delays Gastric Emptying in Humans: A Potential Therapy for Obesity?

Yao

Wang

et al. 2005

Dig Dis Sci

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Obesity is one of the most prevalent health problems in the world with a lack of satisfactory therapies and gastric electrical stimulation has recently been proposed for the treatment of obesity. The aim of this study was to investigate the effects of retrograde gastric pacing (RGP) on food and water intake, and gastric emptying in humans. RGP with a tachygastrial frequency of 9 cycles/min was performed via a pair of submucosal gastric electrodes implanted 5 cm above the pylorus in 12 subjects. The water load test, food intake test and scintigraphic gastric emptying test were performed to assess the efficacy of RGP. RGP resulted in a 13% reduction in the consumption of water, a 16% reduction in food intake and a 15% increase in gastric retention of a solid meal. No significant symptoms were recorded with RGP using the parameters used for the water-load, food intake and scintigraphic gastric emptying tests. Acute RGP at a tachygastrial frequency results in a significant reduction of water and food intake and a delay in gastric emptying without inducing any unacceptable symptoms. It is worthy to explore its therapeutic potential for obesity.

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mentioning

confidence: 99%

Retrograde Gastric Pacing Reduces Food Intake and Delays Gastric Emptying in Humans: A Potential Therapy for Obesity?

Yao

Wang

et al. 2005

Dig Dis Sci

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“…This non-invasive technique can detect gastric arrhythmias (tachygastria and bradygastria) in physiological and pathological situations. [8][9][10][11] There are no data on the effects of meal temperature on the EGG. It is also possible that meal temperature has an effect on the spatial organisation of gastric contractions, independent of any effect on the pacemaker frequency but the available studies are insufficient to give any indication on this possibility.…”

mentioning

confidence: 99%

Effect of drink temperature on antropyloroduodenal motility and gastric electrical activity in humans.

Sun

Penagini

Hebbard

et al. 1995

Gut

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“…The gastric emptying study was repeated in those patients in whom this had initially been carried out (20 patients 1 Electrode positions used in this study. Electrodes 2, 3 and 4 are situated on a transverse line halfway between the lower end of the sternum and the umbilicus.…”

mentioning

confidence: 99%

Electrogastrographic study of gastric myoelectrical activity in patients with unexplained nausea and vomiting.

Geldof¹,

Schee²,

Blankenstein³

et al. 1986

Gut

286

134

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SUMMARY Using cutaneous electrodes an electrogastrographic study was made of gastric myoelectrical activity in both the fasting and postprandial states in 48 patients with unexplained nausea and vomiting and in 52 control subjects. A gastric emptying study, using a radio-labelled solid phase meal, was carried out in 30 of these 48 patients. A follow up study was done after one year. In 48% of the patients abnormal myoelectrical activity was found which was characterised by: (1) instability of the gastric pacemaker frequency; (2) tachygastrias in both the fasting and postprandial states; (3) the absence of the normal amplitude increase in the postprandial electrogastrogram. This last characteristic was correlated with a delayed gastric emptying of solids. The present study shows that with electrogastrography in a heterogeneous group of patients with unexplained nausea and vomiting a subgroup can be discerned with abnormal myoelectrical activity. Our findings suggests that this abnormal myoelectrical activity is related to these symptoms.

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Human gastric atony with tachygastria and gastric retention

Cited by 194 publications

References 10 publications

Retrograde Gastric Pacing Reduces Food Intake and Delays Gastric Emptying in Humans: A Potential Therapy for Obesity?

Retrograde Gastric Pacing Reduces Food Intake and Delays Gastric Emptying in Humans: A Potential Therapy for Obesity?

Effect of drink temperature on antropyloroduodenal motility and gastric electrical activity in humans.

Electrogastrographic study of gastric myoelectrical activity in patients with unexplained nausea and vomiting.

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