2014
DOI: 10.1093/eurheartj/eht099
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Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines

Abstract: This study provides the first evidence that the secretome from EAT promotes myocardial fibrosis through the secretion of adipo-fibrokines such as Activin A.

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Cited by 475 publications
(380 citation statements)
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References 37 publications
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“…In fact, in line with other fat depots [56,57], not only extracellular matrix proteins are remarkably increased in EAT in cardiac pathological conditions [58], but EAT may also induce fibrosis in the neighboring myocardium through the secretion of profibrotic mediators including inflammatory cytokines, growth factors and matrix metalloproteinases [59,60] (Fig. 1).…”
Section: The Emerging Role Of Eat In Cardiac Arrhythmiassupporting
confidence: 55%
See 1 more Smart Citation
“…In fact, in line with other fat depots [56,57], not only extracellular matrix proteins are remarkably increased in EAT in cardiac pathological conditions [58], but EAT may also induce fibrosis in the neighboring myocardium through the secretion of profibrotic mediators including inflammatory cytokines, growth factors and matrix metalloproteinases [59,60] (Fig. 1).…”
Section: The Emerging Role Of Eat In Cardiac Arrhythmiassupporting
confidence: 55%
“…Among the EAT-secreted factors, activin A resulted one of the main potential mediators of the profibrotic effect of EAT secretome on atrial myocardium [59]. Of note, activin A concentration in the EAT secretome is highly variable, with higher levels in predisposing conditions for atrial arrhythmias, such as heart failure [59], obesity and type 2 diabetes [60].…”
Section: The Emerging Role Of Eat In Cardiac Arrhythmiasmentioning
confidence: 99%
“…Charakterystycznymi cechami tego procesu są aktywacja fibroblastów, zwiększone odkładanie się tkanki łącznej oraz włóknienie [78][79][80]. U pacjentów z AF i towarzyszącymi stanami sprzyjającymi AF stwierdza się również nacieczenie przedsionków tkanką tłuszczową, nacieki zapalne, przerost miocytów, martwicę oraz amyloidozę [81][82][83][84]. Przebudowa strukturalna wywołuje rozkojarzenie elektryczne między pęczkami włókien mięśniowych i miejscową niejednorodność przewodzenia [85], co sprzyja pobudzeniom nawrotnym (re-entry) i podtrzymaniu arytmii [86].…”
Section: Przebudowa Przedsionków a Czynność Kanałów Jonowychunclassified
“…Obesity not only creates atrial fibrosis 84 , but also increases epicardial fat 84,85 . Furthermore, obesity leads to the infiltration of fat cells into the atrial tissue and to the activation of atrial fat cells, thus modifying atrial electrical function 22,86 , providing a possible mech anism linking obesity and pericardial fat to AF. Therefore, epicardial adipose tissue could be an important health modifier for AF.…”
Section: Fat-cell Infiltration and Activationmentioning
confidence: 99%
“…and mechanisms, and which presents with a variety of symptoms and evolution patterns 2,[15][16][17][18][19][20][21][22][23] . However, none of the current management decisions considers the variable pathophysiology of AF, thereby ignoring the opportunity for tailored, personalized approaches that target the major drivers for AF 24 .…”
mentioning
confidence: 99%