Human Eosinophil Cationic Proteins (ECP and EPX) and Their Suppressive Effects on Lymphocyte Proliferation

Peterson, Christer; Skoog, Valdemar; Venge, Per

doi:10.1016/s0171-2985(86)80013-4

Cited by 92 publications

(44 citation statements)

References 25 publications

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“…A vascular infiltration of activated eosino phils may induce contraction of vascular smooth muscle, since activated eosinophils make large amounts of LTC4 [27]. Extracellular release of ECP may also modulate the cellular response of grafts under rejection, since ECP has been shown to inhibit the lymphocyte proliferation in duced by phytohaemogglutinin or mixed lymphocyte reactions [28], Furthermore, infiltration of activated eo sinophils may have modulating effects on the inflamma tory process of the kidney by the release of arylsulfatase B, phospholipase D, histaminase, 15-HETE, and other chemical mediators as well [29][30][31][32][33]. At present, the mech anisms regulating the tissue-damaging effects of the eo sinophil and its modulating effects on inflammatory events are unknown.…”

Section: Discussionmentioning

confidence: 99%

Activated Eosinophil Infiltration and Deposits of Eosinophil Cationic Protein in Renal Allograft Rejection

Hällgren

Bohman²,

Fredens³

1991

Nephron

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Eosinophil involvement in renal allograft rejection was elucidated with immunocytochemical techniques. Sections of renal biopsies were stained for immunoreactive eosinophils and extracellular deposits of eosinophil cationic protein (ECP). Activated eosinophils were identified by means of alkaline-phosphatase-linked monoclonal antibodies. In biopsies from patients with acute rejection of the interstitial type, a varying degree of eosinophil infiltration in the interstitium was seen. Minor extracellular deposits of ECP were present in areas with activated eosinophils. In acute vascular rejection, dense infiltration of activated eosinophils and secreted ECP were found in infarcted areas and in arterial walls with necrotic lesions. Dense accumulation of activated eosinophils and extracellular deposits of ECP were also seen in biopsies from non-transplanted patients with necrotizing renal vasculitides. These findings suggest that cytotoxic eosinophil granule proteins are involved in vascular injury in renal graft rejection and in necrotizing renal vasculitides. Eosinophil activation may also have a pathophysiological role in the interstitial lesions in renal graft rejection.

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Section: Discussionmentioning

confidence: 99%

Activated Eosinophil Infiltration and Deposits of Eosinophil Cationic Protein in Renal Allograft Rejection

Hällgren

Bohman²,

Fredens³

1991

Nephron

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“…These mediators are contained in intracellular WBC granules, and are released in a time-dependent manner as the WBCs deteriorate during storage [59]. It has been shown that at least some of these biologic response modifiers (histamine, eosinophil cationic protein, eosinophil protein X, TGF-β) may contribute to the development of immunosuppression and tissue damage by inhibition of neutrophils, cytotoxic T-cells and natural killer cells [60], [61], [62], [63].…”

Section: Immunosuppressionmentioning

confidence: 99%

Transfusion-transmissible infections and transfusion-related immunomodulation

Buddeberg

Schimmer

Spahn

2008

Best Practice & Research Clinical Anaesthesiology

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Transfusion-transmissible infections and transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years. However, after human immunodeficiency virus and hepatitis B and C virus transmission were successfully reduced, new pathogens are threatening the safety of the blood supply, especially in the face of rising numbers of immunocompromised transfusion recipients. Despite new standards in the manufacture and storage of blood products, bacterial contamination still remains a considerable cause of transfusion-related morbidity and mortality. Better allograft survival in kidney transplant patients and higher cancer recurrence rate in surgical oncology patients after allogeneic blood transfusions highlighted a previously underestimated side-effect: transfusion-related immunomodulation (TRIM). The precise pathomechanism still remains uncertain; however, its mostly deleterious effects--such as a higher incidence of postoperative or nosocomial infections--is increasingly accepted. Although transfusion-related immunomodulation is thought to be mediated mainly by donor white blood cells, the benefit of leukoreduction on overall mortality and on infectious complications is highly debatable. Transfusion-transmissible infections and Transfusion-related immunomodulation Transfusion-transmissible infections and Transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years.

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“…Histamine is well-known to play a significant role in immunosuppression [28,79], growth of tumor tissue [64,80], leukemia [81], autoimmune diseases [82], and in several physiological and pathophysiological processes [79]. ECP and EPX may contribute to immunosuppression [83], and tissue damage [84], and lead to neurotoxic reactions [85], while MPO may amplify toxic reactions and tissue damage by free oxygen radicals [86][87][88][89][90]. Furthermore, MPO may activate carcinogens, which may lead to cancer development [91], and MPO-induced tissue damage may facilitate tumor cell dissemination and implantation as well [92].…”

Section: Leukocyte-and Platelet-derived Bioactive Substancesmentioning

confidence: 99%

Clinical Impact of Bioactive Substances in Blood Components: Implications for Leukocyte Filtration

Nielsen¹

1998

Transfus Med Hemother

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Human Eosinophil Cationic Proteins (ECP and EPX) and Their Suppressive Effects on Lymphocyte Proliferation

Cited by 92 publications

References 25 publications

Activated Eosinophil Infiltration and Deposits of Eosinophil Cationic Protein in Renal Allograft Rejection

Activated Eosinophil Infiltration and Deposits of Eosinophil Cationic Protein in Renal Allograft Rejection

Transfusion-transmissible infections and transfusion-related immunomodulation

Clinical Impact of Bioactive Substances in Blood Components: Implications for Leukocyte Filtration

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