Due to unfavourable natural conditions (poor soils, lack of water, special relief conditions), karst terrains have always been relatively sparsely populated, and they have been seriously affected by recent depopulation processes. However, the creation of national parks on karst terrains and the recent increase of (geo)tourism may influence and even turn these population trends. Our study examines the validity of this statement in the context of Vikos Gorge and Tymphi Mountain (NW Greece). Geological and geomorphological values are presented first, including Vikos Gorge, the glaciokarst landscape of Tymphi and the particular spherical rock concretions. Digital terrain analysis is used to obtain scientifically based, reliable morphometric parameters about Vikos Gorge, and it is found that the maximum gorge depth is 1144 m, the maximum width is 2420 m, and the maximum of depth/width ratio is 0.76. Thereafter, rural depopulation trends are examined and it is found that this region (Zagori) is seriously affected by depopulation. It is observed that there are differences among settlements, and a relative stabilization of population is sensible in only few settlements around Vikos Gorge, which are linked to tourism. As for nature protection, while at the beginning conflicts were perceptible among management and local people, now new conflicts are emerging between growing tourism and nature protection goals.