Human Enamel and Dentin: Effect of Gender, Geographic Location and Smoking Upon Metal Concentrations

Olovčić, Almir; Ramić, Emina; Memić, Mustafa

doi:10.1080/00032719.2019.1646753

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Exposure to lead represents one of the most important health problems because lead affects general health, development of bone and tooth defects and caries formation [1].…”

Section: Introductionmentioning

confidence: 99%

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Expression of a fibronectin in the dental pulp of lead intoxicated rats with experimentally induced diabetes mellitus

et al. 2021

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Introduction/Objective. Lead exposure represents one of the most important factors that affect the general health, including oral health and it is associated with enamel and dentin tooth defects. The aim of this paper was to determine expression of the fibronectin in the pulp of rats with experimentally induced diabetes mellitus (DM), after lead exposure, by using immunohistochemical analysis. Methods. The study was conducted on 42 rats of Wistar strain. Intoxication of rats with lead-acetate was done via drinking water ad libitum. The first group (Exp_14) consisted of 16 rats, which received lead in water for 14 days, the second group (Exp_30) consisted of 16 rats which received lead in water for 30 days at the same concentration (1500 ppm), while the control consisted of 10 healthy rats. Groups Exp_14 and Exp_30 were induced into DM, by using the Alloxan intraperitoneally. Pathohistological and immunohistochemical analysis determined fibronectin expression in pulp, odontoblasts, predentin and dentine of the teeth. Results. High diffuse positivity of fibronectin in group Exp_14 was noticed in 63.6% of rats, in group Exp_30 in 24.0% of rats, while in the control group it was noticed in 50.0% of rats. There was no statistically significant difference in the expression of fibronectin between the examined groups. Conclusion. Lead intoxication through drinking water, for a period of 14 and 30 days, had effect on the expression of fibronectin in the pulp, odontoblasts, predentin and dentin of the teeth of animals experimentally induced DM.

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“…Exposure to lead represents one of the most important health problems because lead affects general health, development of bone and tooth defects and caries formation [1].…”

Section: Introductionmentioning

confidence: 99%

“…Although lead affects the pulp tissue, the number of studies concerning the influence of lead on the reparative dentinogenesis is very limited [1,2].…”

Section: Introductionmentioning

confidence: 99%