Human embryo immune escape mechanisms rediscovered by the tumor

Ridolfi, Laura; Petrini, Massimiliano; Fiammenghi, Laura; Riccobon, Angela; Ridolfi, Ruggero

doi:10.1016/j.imbio.2008.03.003

Cited by 20 publications

(25 citation statements)

References 139 publications

(205 reference statements)

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“…Infection and chronic inflammation contribute to an estimated 25% of all cancers worldwide [25]. In developmental biology, the fetus, which in many ways behaves like an allogenic transplant, also evades maternal immune-surveillance through mechanisms similar to those observed in tumors [26]. Indeed, excessive proliferation (activation of cell cycle genes) and immune-surveillance evasion (suppression of immune genes) allow tumors to obtain territorial expansion advantages compared to normal cells.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Discover prognostic RNAs through identifying lncRNA-miRNA-mRNA triplets in lung squamous cell carcinoma

Yang¹,

Yu²,

An³

2017

Oncotarget

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Carcinogenesis involves multi-level RNA dysregulations, including long noncoding RNA, microRNA and mRNA. Therefore, only looking into one RNA level of cancer is not sufficient to uncover the intricate underlying mechanisms. In this study, an integrative strategy was conducted to systematically analyze the characterized molecular patterns of lung squamous cell carcinoma. Paired samples (cancer and adjacent normal tissues) in each RNA level were retrieved to identify differentially expressed RNAs. The regulatory triplets of lncRNA-microRNA-mRNA were identified after considering dysregulation pattern and evidence of publicly available databases. Thus, 32 significant mRNAs were retrieved by means of random walk algorithm. In four independent datasets, Kaplan-Meier survival and Cox regression analyses both confirmed that the expression of these genes was significantly associated with overall survival of LUSC patients.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Discover prognostic RNAs through identifying lncRNA-miRNA-mRNA triplets in lung squamous cell carcinoma

Yang¹,

Yu²,

An³

2017

Oncotarget

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“…Furthermore, most cancer and cancer‐associated antigens are endogenous self‐antigens, which are more difficult to induce solid CTL responses against than are exogenous non‐self antigens. Thus, the effectiveness of vaccines against such cancer antigens is limited by the fact that tumor cells have evolved a mechanism to evade recognition by the immune system, a process termed immune surveillance …”

mentioning

confidence: 99%

Gold Nanoparticles Displaying Tumor‐Associated Self‐Antigens as a Potential Vaccine for Cancer Immunotherapy

Ahn

Lee

Kang

et al. 2014

Adv Healthcare Materials

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“…In contrast to vaccination against foreign substances, such as virus or bacterial antigens, there is a requirement to break self-tolerance of the immune system toward the self-antigen (1). Vaccination against tumor cell antigens is further complicated by the fact that tumor cells have developed mechanisms to evade recognition by the immune system, for example, by decreased presentation of endogenous peptides on major histocompatibility complex (MHC) (2). We have carefully addressed these issues with the aim of increasing the chances of clinical development of a cancer vaccine.…”

mentioning

confidence: 99%

Vaccination against the extra domain‐B of fibronectin as a novel tumor therapy

et al. 2010

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Monoclonal antibody-based therapies have made an important contribution to current treatment strategies for cancer and autoimmune disease. However, the cost for these new drugs puts a significant strain on the health-care economy, resulting in limited availability for patients. Therapeutic vaccination, defined as induction of immunity against a disease-related self-molecule, is therefore an attractive alternative. To analyze the potential of such an approach, we have developed a vaccine against the extra domain-B (ED-B) of fibronectin. This 91-aa domain, inserted by alternative splicing, is expressed during vasculogenesis in the embryo, but essentially undetectable under normal conditions in the adult. However, ED-B is highly expressed around angiogenic vasculature, such as in tumorigenesis. Here, we demonstrate that it is possible to break self-tolerance and induce a strong antibody response against ED-B by vaccination. Nineteen of 20 vaccinated mice responded with production of anti-ED-B antibodies and displayed a 70% reduction in tumor size compared to those lacking anti-ED-B antibodies. Analysis of the tumor tissue revealed that immunization against ED-B induced several changes, consistent with an attack by the immune system. These data show that tumor vascular antigens are highly interesting candidates for development of therapeutic vaccines targeting solid tumors.

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Human embryo immune escape mechanisms rediscovered by the tumor

Cited by 20 publications

References 139 publications

WITHDRAWN: Discover prognostic RNAs through identifying lncRNA-miRNA-mRNA triplets in lung squamous cell carcinoma

WITHDRAWN: Discover prognostic RNAs through identifying lncRNA-miRNA-mRNA triplets in lung squamous cell carcinoma

Gold Nanoparticles Displaying Tumor‐Associated Self‐Antigens as a Potential Vaccine for Cancer Immunotherapy

Vaccination against the extra domain‐B of fibronectin as a novel tumor therapy

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