Gold Nanoparticles Displaying Tumor‐Associated Self‐Antigens as a Potential Vaccine for Cancer Immunotherapy

Ahn, Sukyung; Lee, In-Hyun; Kang, Sukmo; Kim, Daejin; Choi, Minsuk; Saw, Phei Er; Shin, Eui‐Cheol; Jon, Sangyong

doi:10.1002/adhm.201300597

Cited by 96 publications

(55 citation statements)

References 31 publications

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“…Compared with monoclonal antibodies, which require repeated and long-term administration, the low cost and long-lasting effect of vaccination makes this approach favorable. Recently, Ahn et al reported the use of EDB-carrying gold nanoparticles (AuNPs) as vaccines for immunotherapy of breast cancer 148 . This AuNP-based antigen delivery system induced humoral and cellular immunity against EDB-FN.…”

Section: Targeting Fibronectin In Cancer Therapymentioning

confidence: 99%

Targeting fibronectin for cancer imaging and therapy

2017

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During cancer progression, the extracellular matrix (ECM) undergoes dramatic changes, which promote cancer cell migration and invasion. In the remodeled tumor ECM, fibronectin (FN) level is upregulated to assist tumor growth, progression, and invasion. FN serves as a central organizer of ECM molecules and mediates the crosstalk between the tumor microenvironment and cancer cells. Its upregulation is correlated with angiogenesis, cancer progression, metastasis, and drug resistance. A number of FN-targeting ligands have been developed for cancer imaging and therapy. Thus far, FN-targeting imaging agents have been tested for nuclear imaging, MRI, and fluorescence imaging, for tumor detection and localization. FN-targeting therapeutics, including nuclear medicine, chemotherapy drugs, cytokines, and photothermal moieties, were also developed in cancer therapy. Because of the prevalence of FN overexpression in cancer, FN targeting imaging agents and therapeutics have the promise of broad applications in the diagnosis, treatment, and image-guided interventions of many types of cancers. This review will summarize current understanding on the role of FN in cancer, discuss the design and development of FN-targeting agents, and highlight the applications of these FN-targeting agents in cancer imaging and therapy.

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Section: Targeting Fibronectin In Cancer Therapymentioning

confidence: 99%

Targeting fibronectin for cancer imaging and therapy

2017

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“…For example, Lin et al reported that gold nanoparticle delivery of modified CpG can stimulate macrophages and inhibits tumor growth for immunotherapy [59]. Ahn et al recently demonstrated that gold nanoparticles enable efficient tumor-associated self-antigen delivery to dendritic cells and then activate the cells to facilitate cross-presentation, inducing antigen-specific cytotoxic T cell responses for effective cancer therapy [60]. …”

Section: Nanoparticles and Immune Systemmentioning

confidence: 99%

Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications

Luo

Chang

Lin

2015

BioMed Research International

183

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Nanomaterials, including metal-based nanoparticles, are used for various biological and medical applications. However, metals affect immune functions in many animal species including humans. Different physical and chemical properties induce different cellular responses, such as cellular uptake and intracellular biodistribution, leading to the different immune responses. The goals of this review are to summarize and discuss the innate and adaptive immune responses triggered by metal-based nanoparticles in a variety of immune system models.

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“…Both carbon nanotubes and gold nanoparticles conjugated to tumor-derived antigens have been shown in murine models to suppress tumor growth in an antigen-specific manner, compared to a vaccine comprised of the free antigen [23,24]. Both materials are easily functionalizable and are readily ingested by immune cells.…”

Section: Antigen Delivery and Presentationmentioning

confidence: 99%

“…Both materials are easily functionalizable and are readily ingested by immune cells. However, concerns exist, particularly over solubility, long-term toxicity, and nonbiodegradability [24–26]. More work need to be performed to further evaluate inorganic nanoparticles for vaccine use.…”

Section: Antigen Delivery and Presentationmentioning

confidence: 99%

Synthetic nanovaccines for immunotherapy

Luo¹,

Samandi²,

Wang³

et al. 2017

Journal of Controlled Release

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Although vaccination is historically one of the most successful strategies for the prevention of infectious diseases, development of vaccines for cancer and many chronic infections, such as HIV, malaria, and tuberculosis, has remained a challenge. Strong and long-lasting antigen-specific T cell responses are critical for therapy of these diseases. A major challenge in achieving a robust CD8+ T cell response is the requirement of spatio-temporal orchestration of antigen cross-presentation in antigen-presenting cells with innate stimulation. Here, we discuss the development of nanoparticle vaccine (nanovaccine) that modulates the innate immune system and enhances adaptive immunity with reduced toxicity. We address how nanovaccines can integrate multiple functions, such as lymph node targeting, antigen presentation, and stimulation of innate immunity, to achieve a robust T cell response for immunotherapy.

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Gold Nanoparticles Displaying Tumor‐Associated Self‐Antigens as a Potential Vaccine for Cancer Immunotherapy

Abstract: Golden vaccine for cancers. Gold nanoparticles enable efficient antigen delivery to dendritic cells and then activate the cells to facilitate cross-presentation, inducing antigen-specific cytotoxic T-lymphocyte responses for effective cancer therapy.

Cited by 96 publications

References 31 publications

Targeting fibronectin for cancer imaging and therapy

Targeting fibronectin for cancer imaging and therapy

Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications

Synthetic nanovaccines for immunotherapy

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