Human dural replacement with acellular dermis: Clinical results and a review of the literature

Costantino, Peter D.; Wolpoe, Matthew E.; Govindaraj, Satish; Chaplin, John M.; Sen, Chandranath; Cohen, Michael E.; Gnoy, Alex

doi:10.1002/1097-0347(200012)22:8<765::aid-hed4>3.0.co;2-7

Cited by 70 publications

(36 citation statements)

References 33 publications

(39 reference statements)

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“…The remaining tissue surrounding the large defects cannot be approximated, and thus requires a patch to replace the lost tissue and re-isolate the brain from the external environment. Historically, a variety of materials have been used for this application including metal foils (Beach, 1890), various polymers (Barbolt et al, 2001;Cain et al, 1988;Collins et al, 1991;Friedman et al, 2002;Kumar et al, 2003;Park and Tator, 1998;Vinas et al, 1999), cadaveric human tissues (Abbott and Dupree, 1971;Costantino et al, 2000;Thadani et al, 1988), and xenografts (Anson and Marchand, 1996;Filippi et al, 2001;Parizek et al, 1989;Xu et al, 1988;Zeman et al, 1993). These materials have all had deleterious effects, including leaks (Cain et al, 1990;Sawamura et al, 1999;Zeman et al, 1993), seizure activity (Abbe, 1895;Schlag et al, 2000), hematomas (Ohbayashi et al, 1994;Robertson and Menezes, 1997;Schwartz et al, 1973), Creutzfeldt-Jakob disease (Bernoulli et al, 1977;Budka et al, 1995;Thadani et al, 1988), and significant inflammatory response (Agarwal et al, 1998;Barbolt et al, 2001;Cain et al, 1988;Collins et al, 1991;De Vries et al, 2002;Narotam et al, 1995;Park and Tator, 1998).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the material properties of alginate for the development of hydrogel repair of dura mater

Nunamaker

Otto

Kipke

2011

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Introductionmentioning

confidence: 99%

Investigation of the material properties of alginate for the development of hydrogel repair of dura mater

Nunamaker

Otto

Kipke

2011

Journal of the Mechanical Behavior of Biomedical Materials

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“…This material is efficacious in the treatment of full-thickness burns [9], as a substrate material for oral resurfacing, and in periodontics [10]. Furthermore, ADM has shown promise as a soft-tissue filler in plastic surgery [11] and is used for dural replacement in neurosurgical cases where autogenous tissues are either unavailable or insufficient for reconstruction [12]. Acellular dermal matrix grafts are available commercially, and if it can be shown conclusively that ADM vascularizes and resists infection as well as a fascial autograft, abdominal wall reconstruction might be accomplished even in cases where there is a high risk of infection without subjecting patients to the morbidity associated with harvesting of autologous tissue.…”

mentioning

confidence: 99%

Acellular Dermal Matrix Compared with Synthetic Implant Material for Repair of Ventral Hernia in the Setting of Peri-OperativeStaphylococcus aureusImplant Contamination: A Rabbit Model

Milburn

Holton

Chung

et al. 2008

Surgical Infections

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“…This allograft showed less scarring and has been proved to retain the original dermal structure and biochemical features distinct from granulation tissue. Alloderm is also used for soft-tissue replacement and augmentation [66][67][68][69], ophthalmic reconstructive procedures [70] and dural repair [71,72]. The disadvantage of using Alloderm is its high risk of transmitting infectious diseases and also the availability of cadaveric skin, which is the raw material.…”

Section: Alloderm ®mentioning

confidence: 99%

Clinical application of skin substitutes

Damodaran¹,

Syed

Leigh

et al. 2008

Expert Review of Dermatology

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There has been a perpetual demand for skin and its replacements, which has fuelled advances in the development of novel skin substitutes. The field of skin bioengineering has made mammoth progress in the last 30 years, helped by the advances in the biotechnology and understanding of wound-healing mechanisms. The options for skin substitutes currently range from the cadaveric skin of the past to a number of epidermal, dermal and composite constructs. This review focuses on the clinical applications of various skin substitutes currently available, looking into their advantages and disadvantages and the scope for future improvements. KEYWORDS: allograft • autograft • bioengineering • skin substitute • xenograftOverview of skin substitutes, driving needs Skin is the largest and a vital organ of the body, made of multiple layers of epithelial tissues. Skin plays the most important role in protecting the body against chemicals and pathogens. Its other main functions are insulation, control of evaporation and temperature regulation. The outermost epidermis consists of stratified squamous epithelium with the underlying connective tissue, the dermis, and the hypodermis or basement membrane. The epidermis forms the waterproof, protective wrap over the body surface against mechanical, chemical or thermal stress, and consists of keratinocytes, melanocytes, Langerhans' cells and merkels cells. Keratinocytes undergo differentiation and express several proteins, such as keratins and cadherins. Dermis is situated below the epidermis and consists of dense connective tissue fibers that cushion the body from stress and strain and also gives the dermis its properties of strength, elasticity and extensibility. Collagen is a main protein of the connective tissue and forms the extracellular matrix, which is interwoven with elastin fibers and glycosaminoglycans (GAGs), that supports most tissues and gives cells their outer structure. Skin is exposed to a wide range of insults, such as burns and trauma, resulting in complex wounds, and management of such wounds poses a great challenge. Wound closure requires a material to restore epidermal barrier function and become incorporated into the healing wounds. The use of skin grafts as a wound cover was well established in early 1970. Skin substitutes in the form of allografts (cadaver skin and human amnion) and xenografts (mainly pig) were used with the greatest potential for restoring the altered physiology of skin after severe burns and ulcers. Currently, bioengineered skin products and skin equivalents have been used for treating acute and chronic burn wounds. Since the discovery of keratinocyte sheets for wound-healing applications [1], several modifications in skin substitutes with multiple compositions were designed and tested for treating wounds [1,2]. Recent skin substitutes contain live cells, such as fibroblasts and keratinocytes, in bioengineered scaffolds of natural or synthetic matrices, which provide mechanical stability for the cells to grow [3]. For long-term recovery, the str...

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Human dural replacement with acellular dermis: Clinical results and a review of the literature

Cited by 70 publications

References 33 publications

Investigation of the material properties of alginate for the development of hydrogel repair of dura mater

Investigation of the material properties of alginate for the development of hydrogel repair of dura mater

Acellular Dermal Matrix Compared with Synthetic Implant Material for Repair of Ventral Hernia in the Setting of Peri-OperativeStaphylococcus aureusImplant Contamination: A Rabbit Model

Clinical application of skin substitutes

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