Human dental pulp stem cells respond to cues from the rat retina and differentiate to express the retinal neuronal marker rhodopsin

Bray, Allison; Cevallos, Ricardo R.; Gazarian, Karlen; Lamas, Marta

doi:10.1016/j.neuroscience.2014.09.023

Cited by 42 publications

(29 citation statements)

References 61 publications

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“…The usefulness of DPSC as potential treatment for AMD is not yet known. It was reported recently that DPSC can be induced to differentiate into a photoreceptor phenotype after exposure to conditioned medium from injured organotypic retinal cultures . These DPSC‐derived photoreceptors express the phenotypic marker rhodopsin but their functional activity has not yet been confirmed.…”

Section: Dpsc Treatment For Retinal Repair In Ocular Injury or Diseasementioning

confidence: 99%

Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

et al. 2016

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Dental pulp stem cells (DPSC) are neural crest-derived ecto-mesenchymal stem cells that can relatively easily and non-invasively be isolated from the dental pulp of extracted postnatal and adult teeth. Accumulating evidence suggests that DPSC have great promise as a cellular therapy for central nervous system (CNS) and retinal injury and disease. The mode of action by which DPSC confer therapeutic benefit may comprise multiple pathways, in particular, paracrinemediated processes which involve a wide array of secreted trophic factors and is increasingly regarded as the principal predominant mechanism. In this concise review, we present the current evidence for the use of DPSC to repair CNS damage, including recent findings on retinal ganglion cell neuroprotection and regeneration in optic nerve injury and glaucoma. STEM CELLS 2017;35:61-67 SIGNIFICANCE STATEMENTThis concise review discusses recent developments regarding the novel application of stem cells isolated from the dental pulp for the repair of central nervous system and retinal neurons.

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Section: Dpsc Treatment For Retinal Repair In Ocular Injury or Diseasementioning

confidence: 99%

Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

et al. 2016

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“…Purity, characterization, and scale up manufacturing of cell lines for clinical use are well documented [64], giving ASCs an advantage over BM-MSCs and other less well-defined stem cell populations. MSCs are shown to express RPE markers upon induction with RPE-conditioned medium [65], and have been shown to differentiate into neurons, rods, Müller cells, and retinal ganglion cells [66–68], however, their use in vivo is less established at this time. In some elegant studies, neuroretinal organotypic cultures and co-cultures have been developed to understand the pathophysiology of retinal degenerative diseases.…”

Section: Types Of Stem Cellsmentioning

confidence: 99%

Recent Advances in Retinal Stem Cell Therapy

2017

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Purpose of review Progress in stem cell research for blinding diseases over the past decade is now being applied to patients with retinal degenerative diseases and soon perhaps, glaucoma. However, the field still has much to learn about the conversion of stem cells into various retinal cell types, and the potential delivery methods that will be required to optimize the clinical efficacy of stem cells delivered into the eye. Recent findings Recent groundbreaking human clinical trials have demonstrated both the opportunities and current limitations of stem cell transplantation for retinal diseases. New progress in developing in vitro retinal organoids, coupled with the maturation of bio-printing technology, and non-invasive high-resolution imaging have created new possibilities for repairing and regenerating the diseased retina and rigorously validating its clinical impact in vivo. Summary While promising progress is being made, meticulous clinical trials with cells derived using good manufacturing practice, novel surgical methods, and improved methods to derive all of the neuronal cell types present in the retina will be indispensable for developing stem cell transplantation as a paradigm shift for the treatment of blinding diseases.

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“…These stem cells induced survival of rat ganglion cells and axon regeneration via neurotrophic factor release (Mead, Logan, Berry, Leadbeater, & Scheven, ). Furthermore, Bray et al found that these cells respond to cues from the retina and express markers of mature photoreceptors including rhodopsin and BDNF, thus suggesting a potential role of DPSCs in repairing retinal damage (Bray, Cevallos, Gazarian, & Lamas, ).…”

Section: Dpscs and Neurological Diseasesmentioning

confidence: 99%

Dental pulp stem cells and the management of neurological diseases: An update

Mortada

Bazzal

2017

J of Neuroscience Research

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Medical research in regenerative medicine has brought promising perspectives for the use of stem cells in clinical trials. Stem cells are undifferentiated cells capable of multilineage differentiation and available in numerous sources in the human body. Dental pulp constitutes an attractive source of these cells since collecting mesenchymal stem cells from this site is a noninvasive practice that can be performed after a common surgical extraction of supernumerary or wisdom teeth. Thus, tissue sacrifice is very low and several cytotypes can be obtained owing to these cells' multipotency, in addition to the fact that they can be cryopreserved and stored for long periods. Mesenchymal stem cells have high proliferation rates, making them favorable for clinical application. These multipotent cells, present in biological waste, constitute an appropriate resource in the treatment of many neurological diseases. K E Y W O R D S dentistry, DPSCs, neurological diseases, neurons, regenerative medicine 2 | D P SCs Teeth are divided into two distinct anatomical parts, the crown and the root. They are connected to the supporting bone by the periodontal ligament. The crown comprises enamel, dentin, and pulp. During tooth development, ameloblasts generate enamel, and odontoblasts generate dentin. Once the tooth has erupted, enamel formation stops occurring naturally because of the disappearance of ameloblasts from the surface (Mortada et al., 2017). On the other hand, odontoblasts are present inside the pulp facing the dentin's inner surface throughout life. SignificanceThis article reviews basic characteristics of dental pulp stem cells and highlights recent evidence on their potential role in the management of several neurological diseases. J Neuro Res. 2018;96:265-272. wileyonlinelibrary.com/journal/jnr V C 2017 Wiley Periodicals, Inc. | 265

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Human dental pulp stem cells respond to cues from the rat retina and differentiate to express the retinal neuronal marker rhodopsin

Cited by 42 publications

References 61 publications

Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

Recent Advances in Retinal Stem Cell Therapy

Dental pulp stem cells and the management of neurological diseases: An update

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