Human decidual stromal cells express HLA-G Effects of cytokines and decidualization

Blanco, Osmany; Tirado, Irene; Muñoz-Fernández, Raquel; Abadía-Molina, Ana Clara; García-Pacheco, José Marcos; Peña, José; Olivares, Enrique G.

doi:10.1093/humrep/dem326

Cited by 74 publications

(64 citation statements)

References 43 publications

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“…IFN␥ production by peripheral lymphocytes in very early pregnancy is higher in normal women compared with women with recurrent miscarriage. 42 By contrast, IL-10 is known to be an antiinflammatory cytokine, 45 and as shown in our study and others, 46,47 high levels of IL-10 are associated with successful outcome. We also found that, when the ratios of Th1/Th2 cytokines were calculated, there was a shift towards Th1 cytokines with elevated TNF␣/IL-10 and IFN␥/ IL-10 ratios in patients with TM who subsequently miscarried.…”

Section: Commentsupporting

confidence: 65%

Pro- and antiinflammatory cytokines in threatened miscarriages

Calleja‐Agius

Muttukrishna

Pizzey

et al. 2011

American Journal of Obstetrics and Gynecology

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OBJECTIVE:The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatened miscarriage (TM) and subsequent outcome.STUDY DESIGN: Plasma levels of tumor necrosis factor (TNF)-receptors 1 and 2, TNF␣, interferon gamma (IFN␥), and interleukins (IL) -6 and -10 were measured by flow cytometric bead assays in 80 women with TM: 53 women with normal outcome and 27 women who miscarried. Fluorescent antibody labeling was also performed on whole blood in a subgroup of 27 women of TM: 16 women with normal outcome and 11 women who miscarried. RESULTS:Monocyte expression of TNF␣ and circulating levels of TNF␣, IFN␥, IL-10, IL-6, and TNF-R1 were significantly lower, whereas circulating levels of TNF␣/IL-10, IFN␥/IL-10, and TNF␣/IL-6 ratios were significantly higher, in women with TM who subsequently miscarried, compared with the women with normal outcome.CONCLUSION: An increased Th1 type of immune response, which was similar to that observed in preterm delivery, was found in TM cases that were complicated by a subsequent miscarriage.

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Section: Commentsupporting

confidence: 65%

Pro- and antiinflammatory cytokines in threatened miscarriages

Calleja‐Agius

Muttukrishna

Pizzey

et al. 2011

American Journal of Obstetrics and Gynecology

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“…IL-10 was demonstrated to increase both HLA-G mRNA and cell surface protein expression by monocytes [45], mesenchymal stem cells [50], renal cell carcinoma (RCC) cell lines [51] and human decidua stroma cells [52], and also soluble HLA-G protein by mononuclear cells from patients suffering from non-Hodgkin lymphomas (T-NHL) [53], acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (B-ALL) [52]. Moreover, a reduced placental IL-10 production was observed in preeclampsia [54] and correlates with a low level of expression of HLA-G transcription [38,55].…”

Section: Cytokines Growth Factors and Hormonesmentioning

confidence: 99%

HLA-G in organ transplantation: towards clinical applications

Deschaseaux

Delgado

Pistoia

et al. 2010

Cell. Mol. Life Sci.

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HLA-G plays a particular role during pregnancy in which its expression at the feto-maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation.

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“…28 It has been hypothesized that HLA-G is one of the most important tolerogenic molecules during pregnancy. Although HLA-G is preferentially expressed at high levels in trophoblasts, it is also expressed by decidual stromal cells (the major cellular population in human decidua), 29 DC-10, CD4 1 T cells 26 and DC-SIGN 1 iDCs. 21 Stromal cell expression contributes to tolerance, not only because of their expression on the decidua but also via their interaction with dNK cells.…”

Section: Human Dcsmentioning

confidence: 99%

Liaison between natural killer cells and dendritic cells in human gestation

et al. 2014

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A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN 1 dendritic cells (DCs) and CD56 1 natural killer (NK) cells are of major importance for early pregnancy maintenance, not only generating maternal immunological tolerance but also regulating stromal cell differentiation. Previous reports show the presence of NK-DC cell conjugates in first trimester human decidua, suggesting that these cells may play a role in the modulation of the local immune response within the uterus. While effective immunity is necessary to protect the mother from harmful pathogens, some form of tolerance must be activated to avoid an immune response against fetal antigens. This review article discusses current evidence concerning the functions of DC and NK cells in pregnancy and their liaison in human decidua.

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Human decidual stromal cells express HLA-G Effects of cytokines and decidualization

Abstract: Our results suggest the existence of a network in which hormones together with cytokines regulate the expression of HLA-G by DSC, and that may be of relevance in the maintenance of maternal-fetal tolerance.

Cited by 74 publications

References 43 publications

Pro- and antiinflammatory cytokines in threatened miscarriages

Pro- and antiinflammatory cytokines in threatened miscarriages

HLA-G in organ transplantation: towards clinical applications

Liaison between natural killer cells and dendritic cells in human gestation

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