Human cytomegalovirus-encoded US28 may act as a tumor promoter in colorectal cancer

Cai, Zhenzhai; Xu, Ji; Zhou, Yong Jin; Zheng, Jeffrey; Lin, Kuan‐Yu; Zheng, Shuzhi; Ye, Mengsi; He, Yun; Liu, Changbao; Xue, Zhanxiong

doi:10.3748/wjg.v22.i9.2789

Cited by 25 publications

(24 citation statements)

References 38 publications

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“…Although, the association between HCMV and cancer is arguable, there are documentations which reveal that progression of some tumors could be intensified by the proteins named US28, pp65, IE1, encoded by HCMV genes during the phase of latent infection (Soroceanu et al, 2011;Maussang et al, 2009;Cai et al, 2016;Lucas, 2011). PP65 is the most abundant virion protein and non-infectious viral particles that are assembled during active infection (Libard et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Human Cytomegalovirus DNA among Women with Breast Cancer

Sepahvand

Makvandi

Samarbafzadeh

et al. 2019

Asian Pac J Cancer Prev

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Section TitleBreast cancer is the most common cause of death among women worldwide. Although there are many known risk factors in breast cancer development, infectious diseases have appeared as one of the important key to contribute to carcinogenesis formation. The effects of Human Cytomegalovirus (HCMV) on women with breast cancer has been recently studied and reported. To contribute to this research trend, this study was conducted to evaluate the association between HCMV and the women with breast cancer.Objective:This experiment aimed to evaluate HCMV DNA in women with breast cancer in Ahvaz city, Iran. Materials and Methods:A total of 37 formalin fixed paraffin embedded tissues of the patients with ductal breast carcinoma and 35 paraffin embedded tissues of the patients with fibro adenoma as control group were collected. The deparaffinization of all the samples were carried out and the DNA was extracted. Initially, the PCR test was carried out to detect beta –globulin DNA as an internal control. For those samples positive for beta –globulin DNA, Polymerase Chain reaction (PCR) was used to detect HCMV for the tests and control samples. Results:Among 37 ductal breast carcinoma, 20 (54.04%) cases were proved positive for HCMV DNA by PCR. While among the 35 control group (fibroadenoma), 10 (28.57%) cases were positive for HCMV DNA (P >0.028). The prevalences of HCMV DNA among the age groups 30-39, 40-49 and >50 years were 7 (72.22%), 9 (69.23%), 4 (57.14%), respectively (P=0.066). A high frequency of HCMV DNA was detected in tumor grade III, 13/18 (58.33%) compared with tumor grade II, 7/19 (36.84%) (p=0.044). A high frequency of 16/24 (66.66%) of HCMV DNA was found in invasive ductal breast cancer compared with 4/13 (30.76%) HCMV DNA in situ (P<0.028). Conclusion:A high prevalence of 54.05% HCMV was found among the patients with ductal carcinoma. The percentages of the high prevalence of HCMV among age group (40-49) years, tumors grades, and invasive stage were (69.23%), (58.33%), (66.66%), respectively. Further study of HCMV in the latency phase in patients with ductal carcinoma would be necessary to extend our knowledge.

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Section: Discussionmentioning

confidence: 99%

Human Cytomegalovirus DNA among Women with Breast Cancer

Sepahvand

Makvandi

Samarbafzadeh

et al. 2019

Asian Pac J Cancer Prev

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“…The detection of HCMV DNA might be a signal for malignant change of colorectal tissues but might not be an independent factor to predict the level of malignancy. However it had been reported that the distribution of HCMV proteins showed dramatic difference in tumor tissues (CRC or glioma) depending on the tumor histology [35, 36]. Viral non-coding RNAs regulatory proteins determined HCMV-induced oncomodulation thus affecting differentiation of tumor cells [37].…”

Section: Discussionmentioning

confidence: 99%

Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis

et al. 2016

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Human cytomegalovirus infection (HCMV) has been recently considered as a factor for tumorigenesis. The current study used meta-analytical techniques to explore the prevalence of HCMV in tumor tissues and the relationship between human cytomegalovirus and colorectal cancer (CRC) risk. 11 studies detecting HCMV DNA in tumor tissues were included in meta-analysis. The prevalence rate and odds ratio (OR) were two main parameters. The overall prevalence of human cytomegalovirus DNA in tumor tissues were 27.5% (95% CI = 17.2%−37.8%). Binary logistic regression showed that the studies reported before 2010 involving formalin-fixed specimens from patients in developed region represented a lower proportion of HCMV. The tumor tissues had a significantly higher rate of virus infection compared with normal tissues (OR = 6.59, 95% CI = 4.48−9.69, I2 = 0%, P = 0.71). Subgroup analysis revealed the prevalence of the virus didn't differ in patients with different tumor stages, in tumor cells with different histologic grades, also in different kinds of specimen (polyp and adenocarcinoma). The results of current study suggested a statistically association between the virus infection and an increased risk of colorectal cancer.

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“…Human Cytomegalovirus (HCMV) is a beta‐herpesvirus implicated in many human malignancies, including colon, breast, and prostate cancers, as well as the salivary glands muco‐epidermoid carcinomas (Cai et al, ). Currently, studies in this area suggest an “oncomodulatory” function for this virus, by which the virus may accelerate the promotion of tumors growth by affecting cancer‐related events, such as cell control pathways, tumor invasiveness, apoptosis, and angiogenesis in a previously established tumor; mechanisms, which are mediated by HCMV genes (e.g., US28 and UL36) (Michaelis, Doerr, & Cinatl, ).…”

Section: Colorectal Cancermentioning

confidence: 99%

Role of viruses in gastrointestinal cancer

Mirzaei¹,

Goudarzi²,

Eslami³

et al. 2017

Journal Cellular Physiology

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Gastrointestinal cancers are a global public health problem, which represent a vast majority of all cancer‐caused deaths in both men and women. On the other hand, viral pathogens have been long implicated as etiological factors in the onset of certain human cancers, including gastrointestinal tumors. In this regard, Human Papilloma Virus (HPV), Epstein‐Barr Virus (EBV), and John Cunningham Virus (JCV) have been more strongly suggested to be involved in gastrointestinal carcinogenesis; so that, the association of HPV with oropharyngeal and anal cancers and also the association of EBV with gastric cancer have been etiologically confirmed by epidemiological and experimental investigations. Although, the association of other viruses is less evident, but may rely on co‐factors for their oncogenic roles. Therefore, to improve the prevention and treatment of these classes of cancer, their association with viral agents as potential risk factors should be investigated with care. In this respect, the present review has focused on the existing literature on the subject of viral involvement in gastrointestinal tumorgenesis, by covering and discussing various gastrointestinal cancers, corresponding viral agents and their oncogenic aspects and then summarizing evidences either supporting or rejecting a causal role of these pathogens in gastrointestinal malignancies.

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Human cytomegalovirus-encoded US28 may act as a tumor promoter in colorectal cancer

Abstract: US28 expression is predictive of poor prognosis and may promote CRC.

Cited by 25 publications

References 38 publications

Human Cytomegalovirus DNA among Women with Breast Cancer

Human Cytomegalovirus DNA among Women with Breast Cancer

Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis

Role of viruses in gastrointestinal cancer

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