Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis

Bai, Bingjun; Wang, Xingxing; Chen, Engeng; Zhu, Hongbo

doi:10.18632/oncotarget.12523

Cited by 52 publications

(45 citation statements)

References 34 publications

(39 reference statements)

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“…Previously our group has shown that TB patients have increased levels of HCMV IgG [17] and that HCMV positive infants (as measured by HCMV IFN-c ELISPOT) were at higher risk of progressing to active TB disease [13]. HCMV infection, being linked to poor long-term health outcomes [28,29] and large immune system subversion [16,30], may be acting to manipulate mycobacterial antibodies which may be contributing to protective mechanisms against M.tb infection.…”

Section: Discussionmentioning

confidence: 99%

HIV, HCMV and mycobacterial antibody levels: a cross‐sectional study in a rural Ugandan cohort

Stockdale

Nash

Nalwoga

et al. 2018

Tropical Med Int Health

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Objectives A growing evidence base implicates human cytomegalovirus ( HCMV ) as a risk factor for TB disease. We investigated total IgG and mycobacteria‐specific antibodies in a cross‐sectional study nested within a rural Ugandan General Population Cohort ( GPC ), in relation to HIV infection and the magnitude of HCMV IgG response. Methods Sera from 2189 individuals (including 27 sputum‐positive TB cases) were analysed for antibodies against mycobacteria (Ag85A, PPD , LAM , ESAT 6/ CFP 10) and HCMV , tetanus toxoid ( TT ) and total IgG. Results Anti‐mycobacterial antibodies increased with age until approximately 20 years, when they plateaued. Higher HCMV exposure (measured by IgG) was associated with lower levels of some anti‐mycobacterial antibodies, but no increase in total IgG. HIV infection was associated with a decrease in all anti‐mycobacterial antibodies measured and with an increase in total IgG. Conclusions The increase in anti‐mycobacterial antibodies with age suggests increasing exposure to non‐tuberculous mycobacteria ( NTM ), and to M.tb itself. HIV infection is associated with decreased levels of all mycobacterial antibodies studied here, and high levels of HCMV IgG are associated with decreased levels of some mycobacterial antibodies. These findings point towards the importance of humoral immune responses in HIV / TB co‐infection and highlight a possible role of HCMV as a risk factor for TB disease.

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Section: Discussionmentioning

confidence: 99%

HIV, HCMV and mycobacterial antibody levels: a cross‐sectional study in a rural Ugandan cohort

Stockdale

Nash

Nalwoga

et al. 2018

Tropical Med Int Health

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“…89,[130][131][132] A recent meta-analysis suggested a statistical association between CMV infection and an increased risk of CRC. 133 In patients with CRC, CMV RNA transcripts and protein appear to be specifically localized to the cytoplasm of neoplastic mucosal epithelium compared with non-transformed cells. 132,134 The presence of CMV in tumour tissue is associated with an unfavourable outcome in elderly patients with CRC and predicts poor disease-free survival independent of TNM staging.…”

Section: Colorectal Cancermentioning

confidence: 96%

“…Several studies have identified CMV in colorectal cancer (CRC) tissue; about ~ 40% of CRC specimens generally test CMV positive . A recent meta‐analysis suggested a statistical association between CMV infection and an increased risk of CRC . In patients with CRC, CMV RNA transcripts and protein appear to be specifically localized to the cytoplasm of neoplastic mucosal epithelium compared with non‐transformed cells .…”

Section: Cmv‐specific Memory Inflation Shapes Global and Anti‐tumour mentioning

confidence: 99%

The impact of inflationary cytomegalovirus‐specific memory T cells on anti‐tumour immune responses in patients with cancer

et al. 2018

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Human cytomegalovirus (CMV) is a ubiquitous, persistent beta herpesvirus. CMV infection contributes to the accumulation of functional antigen-specific CD8 T-cell pools with an effector-memory phenotype and enrichment of these immune cells in peripheral organs. We review here this 'memory T-cell inflation' phenomenon and associated factors including age and sex. 'Collateral damage' due to CMV-directed immune reactivity may occur in later stages of life - arising from CMV-specific immune responses that were beneficial in earlier life. CMV may be considered an age-dependent immunomodulator and a double-edged sword in editing anti-tumour immune responses. Emerging evidence suggests that CMV is highly prevalent in patients with a variety of cancers, particularly glioblastoma. A better understanding of CMV-associated immune responses and its implications for immune senescence, especially in patients with cancer, may aid in the design of more clinically relevant and tailored, personalized treatment regimens. 'Memory T-cell inflation' could be applied in vaccine development strategies to enrich for immune reactivity where long-term immunological memory is needed, e.g. in long-term immune memory formation directed against transformed cells.

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“…During active infection, HCMV expresses several proteins, some are essential for its replication and a largr amount may interfere with the cellular and immunological functions, enabling the virus to coexist with its host [5]. Recently, several studies provide evidence that HCMV proteins and nucleic acid has been detected in tissue from several malignancies, including cervical [6], breast [7], colorectal [8], as well as glioblastoma [9] and neuroblastoma [10]. Shanmughapriya et al [11] first found HCMV-glycoprotein DNA by polymerase chain reaction analysis in 50% of tumor tissue specimens from ovarian cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Detection of Human Cytomegalovirus in Patients with Epithelial Ovarian Cancer and its Impacts on Survival

Yin

Chen

Zhao

et al. 2020

Preprint

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Background: The cause of epithelial ovarian cancer(EOC) is not elucidated. It has been proved that infectious agents could contribute to ovarian carcinogenesis. Human cytomegalovirus (HCMV) has been detected in several types of tumors. Objective: To investigate the potential role of HCMV infection in EOC, we evaluated the prevalence of HCMV proteins in EOC tissue sections and its impacts on patients’ survival. Methods: Formalin-fixed, paraffin-embedded tissues from 66 patients with EOC and 30 patients with benign ovarian cystadenoma were studied. Specimens were detected for expression of HCMV immediate-early protein (IE) and HCMV tegument protein (pp65) by immunohistochemistry. Results: HCMV-IE protein expression was detected in 82% of EOC and 36% of benign tumors; pp65 was detected in 97% of EOC and 63% of benign tumors. Extensive expression of HCMV-IE protein was associated with higher stage of EOC. Reactivation of latent HCMV within the tumor at interval debulking surery may be induced by neoadjuvant chemotherapy before surgery. Extensive HCMV-IE expression was associated with shorter median overall survival than focal or negative expression (39 versus 41 months, P = 0.03). Conclusions: This study demonstrate a high prevalence of HCMV proteins in tissue sections from patients with EOC. HCMV infections can be potential risks for EOC development. The relationship between HCMV and clinical outcomes highlight the need for further researches on the oncomodulatory role of HCMV in ovarian cancer.

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Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis

Cited by 52 publications

References 34 publications

HIV, HCMV and mycobacterial antibody levels: a cross‐sectional study in a rural Ugandan cohort

HIV, HCMV and mycobacterial antibody levels: a cross‐sectional study in a rural Ugandan cohort

The impact of inflationary cytomegalovirus‐specific memory T cells on anti‐tumour immune responses in patients with cancer

Detection of Human Cytomegalovirus in Patients with Epithelial Ovarian Cancer and its Impacts on Survival

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