2008
DOI: 10.1158/1535-7163.mct-08-0430
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Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

Abstract: The targeting of solid tumors requires delivery tools that resist intracellular and extracellular inactivation, and that are taken up specifically by tumor cells. We have shown previously that the recombinant nontoxic B-subunit of Shiga toxin (STxB) can serve as a delivery tool to target digestive tumors in animal models. The aim of this study was to expand these experiments to human colorectal cancer. Tissue samples of normal colon, benign adenomas, colorectal carcinomas, and liver metastases from 111 patient… Show more

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Cited by 78 publications
(94 citation statements)
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References 42 publications
(57 reference statements)
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“…The nontoxic B-subunit of the bacterial Shiga toxin (STxB) may be used as an efficient and specific tool for tumor targeting. The cellular STxB receptor, the neutral glycosphingolipid globotriaosylceramide Gb 3 (Gala1-4Galb1-4Glcb1-1Cer), or CD77, is overexpressed in colon carcinoma (6,21), pancreatic (5,8), and breast cancer (25). Moreover, STxB can be functionalized and coupled to specific agents for noninvasive or endoscopic tumor imaging, which has successfully been demonstrated in preclinical models (28,36).…”
Section: Discussionmentioning
confidence: 99%
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“…The nontoxic B-subunit of the bacterial Shiga toxin (STxB) may be used as an efficient and specific tool for tumor targeting. The cellular STxB receptor, the neutral glycosphingolipid globotriaosylceramide Gb 3 (Gala1-4Galb1-4Glcb1-1Cer), or CD77, is overexpressed in colon carcinoma (6,21), pancreatic (5,8), and breast cancer (25). Moreover, STxB can be functionalized and coupled to specific agents for noninvasive or endoscopic tumor imaging, which has successfully been demonstrated in preclinical models (28,36).…”
Section: Discussionmentioning
confidence: 99%
“…Cellular morphology and growth characteristics were analyzed regularly, and no phenotype changes were observed through the study. STxB-Cy3, or BSA-Cy3 as control, was added at final concentration of 2.5 mg/mL as published earlier (6).…”
Section: Cell Culture and Stxb Uptake Assaysmentioning
confidence: 99%
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“…Gb3 is overexpressed in many human cancers, such as breast cancer, colon carcinoma and lymphoma (28). The STxB retrograde transport pathway has been applied as a delivery tool for chemotherapy against cancer (13,29).…”
Section: Discussionmentioning
confidence: 99%