Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells

Kessel, Aharon; Haj, Tharwat; Peri, Regina; Snir, Ayelet; Melamed, Doron; Sabo, Edmond; Toubi, Elias

doi:10.1016/j.autrev.2011.11.018

Cited by 234 publications

(194 citation statements)

References 33 publications

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“…3F). In aggregate, these results indicate that the CD39 high B-cell subset has the phenotype previously described for Breg 13,17 and that high levels of CD39 and IL-10 expression in this B-cell subset are consistent with its regulatory potential.…”

Section: Cd39 High B Cells Have a Regulatory Phenotypesupporting

confidence: 80%

“…However, recent studies identified a small subset of CD19 C CD25 C circulating B cells that can suppress functions of other lymphocytes. 13 This B-cell subset ("Breg") directly suppresses proliferation of CD4 C T cells by producing IL-10 or TGF-b or acting indirectly, promotes expansion and functions of Treg. 13 Our recent study shows that upon in vitro activation, human CD19 C B cells inhibit Teff proliferation; in contrast, resting B cells promote Teff proliferation.…”

Section: Introductionmentioning

confidence: 99%

“…13 This B-cell subset ("Breg") directly suppresses proliferation of CD4 C T cells by producing IL-10 or TGF-b or acting indirectly, promotes expansion and functions of Treg. 13 Our recent study shows that upon in vitro activation, human CD19 C B cells inhibit Teff proliferation; in contrast, resting B cells promote Teff proliferation. 14 T-cell suppression by activated B cells is associated with upregulation of CD39 on the B-cell surface.…”

Section: Introductionmentioning

confidence: 99%

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Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)

et al. 2016

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CD39 and CD73 are key enzymes in the adenosine (ADO) pathway. ADO modulates pathophysiological responses of immune cells, including B cells. It has recently emerged that a subpopulation of ADOproducing CD39 C CD73 C B cells has regulatory properties. Here, we define the CD39 high subset of these cells as the major contributor to the regulatory network operated by human B lymphocytes. Peripheral blood B cells were sorted into CD39 neg , CD39 inter and CD39 high subsets. The phenotype, proliferation and IL-10 secretion by these B cells were studied by flow cytometry. 5 0 -AMP and ADO levels were measured by mass spectrometry. Agonists or antagonists of A 1 R, A 2A R and A 3 R were used to study ADO-

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Section: Cd39 High B Cells Have a Regulatory Phenotypesupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)

et al. 2016

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“…In the tumor microenvironment, Bregs induce conversion from resting CD4 T cells to Tregs to support metastatic growth and promote Tregs in HCC [13][14][15]. Breg increase FoxP3 and CTLA-4 expression in Treg cells, which was mainly dependent on direct contact between Breg and Treg cells, but was also TGF-b although not IL-10 dependent [16].…”

Section: Breg Versus Tregmentioning

confidence: 95%

Bregs in Chronic HBV: Is It Time for Bragging Rights?

Alatrakchi

2015

Dig Dis Sci

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“…The studies on contact-dependent mechanisms of Breg cells have so far mainly focused on the role of CD80 and CD86 (Blair et al 2010, Iwata et al 2011, Kessel et al 2011) but the expression of the negative costimulatory molecules programme death ligands (PD-L) 1 (CD274) and PD-L2 (CD273)…”

Section: Regulatory B (Breg) Cellsmentioning

confidence: 99%

The Contribution of Innate Immunity to the Pathogenesis of ANCA-associated Vasculitis

Söderberg¹

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"Nog finns det mål och mening med vår färd -men det är vägen som är mödan värd" − Karin Boye SupervisorMårten Segelmark, Linköping University, Sweden Co-supervisorsPer Eriksson, Linköping University, Sweden Jan Ernerudh, Linköping University, Sweden Tino Kurz, Linköping University, Sweden Faculty opponentPeter Heeringa, University of Groningen, The Netherlands Abstract Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitute a group of vasculitides characterized by neutrophil-rich necrotizing inflammation of small vessels and the presence of ANCA in the circulation. Dying neutrophils surrounding the walls of small vessels are a histological hallmark of AAV. Traditionally it has been assumed that these neutrophils die by necrosis, but neutrophil extracellular traps (NETs) have recently been visualized at the sites of vasculitic lesions. NETs were first described to be involved in capture and elimination of pathogens but dysregulated production and/or clearance of NETs are thought to contribute to vessel inflammation in AAV; directly by damaging endothelial cells and indirectly by acting as a link between the innate and adaptive immune system through the generation of pathogenic PR3-ANCA and MPO-ANCA that can activate neutrophils. ANCA can, however, be found in all individuals and are therefore suggested to belong to the repertoire of natural antibodies produced by innate-like B cells, implying that not all ANCA are pathogenic.In paper I, we found neutrophils in patients to be more prone to undergo NETosis/necrosis spontaneously compared with neutrophils in healthy controls (HC), as well as that active patients possessed elevated levels of NETs in the circulation. Our results also suggest that ANCA during remission could contribute to the clearance of NETs as we observed an inverse relation between ANCA and NETs. In paper II, we observed neutrophils in patients to be more easily activated upon ANCA stimulation as they produced more ROS than neutrophils in HC. In paper III, we showed for the first time that cells of adaptive immunity (B and T cells)

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Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells

Cited by 234 publications

References 33 publications

Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)

Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)

Bregs in Chronic HBV: Is It Time for Bragging Rights?

The Contribution of Innate Immunity to the Pathogenesis of ANCA-associated Vasculitis

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Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells

Cited by 234 publications

References 33 publications

Phenotypic and functional characteristics of CD39highhuman regulatory B cells (Breg)

Phenotypic and functional characteristics of CD39highhuman regulatory B cells (Breg)

Bregs in Chronic HBV: Is It Time for Bragging Rights?

The Contribution of Innate Immunity to the Pathogenesis of ANCA-associated Vasculitis

Contact Info

Product

Resources

About

Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)

Phenotypic and functional characteristics of CD39^highhuman regulatory B cells (Breg)