Human Breath Gas Analysis in the Screening of Gestational Diabetes Mellitus

Halbritter, Susanne; Fedrigo, Mattia; Höllriegl, Vera; Szymczak, Wilfried; Maier, Joerg M.; Ziegler, Anette‐Gabriele; Hummel, Michael

doi:10.1089/dia.2012.0076

Cited by 34 publications

(32 citation statements)

References 39 publications

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“…Niacin lowers insulin effectiveness and can cause an increase in blood glucose levels (BGLs) [172]. Gestational diabetes mellitus (GDM) is another form of diabetes [172, 173]. It can develop when a pregnant woman has limited beta cell capacity and cannot respond to the additional insulin demand.…”

Section: Diabetes Mellitus and Breath Testmentioning

confidence: 99%

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Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

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Analysis of volatile organic compounds (VOCs) emanating from human exhaled breath can provide deep insight into the status of various biochemical processes in the human body. VOCs can serve as potential biomarkers of physiological and pathophysiological conditions related to several diseases. Breath VOC analysis, a noninvasive and quick biomonitoring approach, also has potential for the early detection and progress monitoring of several diseases. This paper gives an overview of the major VOCs present in human exhaled breath, possible biochemical pathways of breath VOC generation, diagnostic importance of their analysis, and analytical techniques used in the breath test. Breath analysis relating to diabetes mellitus and its characteristic breath biomarkers is focused on. Finally, some challenges and limitations of the breath test are discussed.

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Section: Diabetes Mellitus and Breath Testmentioning

confidence: 99%

“…An oral glucose tolerance test is the general approach for GDM screening. A recent study used breath gas analysis using PTR-MS for screening GDM [173]. …”

Section: Diabetes Mellitus and Breath Testmentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

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“…For multiple dependent variables, in which two or more dependent variables are included, multivariate analysis of variance (MANOVA) and canonical correlation analysis are applied. Recently, Halbritter and co-workers [ 165 ] used MANOVA technique to discriminate according to whether the pregnant women had gestational diabetes mellitus, impaired glucose tolerance, or normal glucose tolerance, by means of analysing the women´s breath by PTR-MS and correlating it with the oral glucose tolerance test.…”

Section: Biomarkers Vs Biomarker Profilesmentioning

confidence: 99%

Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications

2014

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Breath analysis is a promising field with great potential for non-invasive diagnosis of a number of disease states. Analysis of the concentrations of volatile organic compounds (VOCs) in breath with an acceptable accuracy are assessed by means of using analytical techniques with high sensitivity, accuracy, precision, low response time, and low detection limit, which are desirable characteristics for the detection of VOCs in human breath. “Breath fingerprinting”, indicative of a specific clinical status, relies on the use of multivariate statistics methods with powerful in-built algorithms. The need for standardisation of sample collection and analysis is the main issue concerning breath analysis, blocking the introduction of breath tests into clinical practice. This review describes recent scientific developments in basic research and clinical applications, namely issues concerning sampling and biochemistry, highlighting the diagnostic potential of breath analysis for disease diagnosis. Several considerations that need to be taken into account in breath analysis are documented here, including the growing need for metabolomics to deal with breath profiles.

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“…Oxidative stress has also been analyzed in relation to diabetes mellitus [189]. Aside from the two main types of diabetes, another study reports a number of volatile biomarkers discovered in the breath of patients with gestational diabetes mellitus [190]. A detailed overview of the selected techniques used for breath ana lysis in diabetes mellitus was given by Miekisch et al [191].…”

Section: Perspective | Calenic and Amannmentioning

confidence: 99%

Detection of Volatile Malodorous Compounds in Breath: Current Analytical Techniques and Implications in Human Disease

Calenic

Amann

2014

Bioanalysis

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For the last few decades intense scientific research has been placed on the relationship between trace substances found in exhaled breath such as volatile organic compounds (VOC) and a wide range of local or systemic diseases. Although currently there is no general consensus, results imply that VOC have a different profile depending on the organ or disease that generates them. The association between a specific pathology and exhaled breath odor is particularly evident in patients with medical conditions such as liver, renal or oral diseases. In other cases the unpleasant odors can be associated with the whole body and have a genetic underlying cause. The present review describes the current advances in identifying and quantifying VOC used as biomarkers for a number of systemic diseases. A special focus will be placed on volatiles that characterize unpleasant breath 'fingerprints' such as fetor hepaticus; uremic fetor; fetor ex ore or trimethylaminuria.

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Human Breath Gas Analysis in the Screening of Gestational Diabetes Mellitus

Abstract: Noninvasive BGA in challenge response studies was successfully applied to GDM diagnosis and offered an insight into metabolic pathways involved. We propose a new approach to the identification of diagnosis thresholds for GDM screening.

Cited by 34 publications

References 39 publications

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications

Detection of Volatile Malodorous Compounds in Breath: Current Analytical Techniques and Implications in Human Disease

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