Human breast tumor cells express IL-10 and IL-12p40 transcripts and proteins, but do not produce IL-12p70

Heckel, Mark; Wolfson, Alexey D.; Slachta, C.A.; Schwarting, Roland; Salgame, Padmini; Katsetos, Christos D.; Platsoucas, Chris D.

doi:10.1016/j.cellimm.2010.09.010

Cited by 36 publications

(24 citation statements)

References 80 publications

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“…IL-10 transcripts were also found to be expressed in 14/15 primary breast adenocarcinomas and in 5/8 established breast tumor lines [107]. This supported by immunohistochemistry and immunoprecipitation from lysates and supernatants showed that established breast tumor lines produces IL-10 protein.…”

Section: Il-10 As Prognostic Indicator For Breast Cancermentioning

confidence: 64%

Role of interleukin-10 in breast cancer

Ullah

Changkija

Konwar

2011

Breast Cancer Res Treat

152

113

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Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the intensity and duration of immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of target cells. Different cytokines are known to have diverse role in breast cancer initiation and progression. Interleukin-10 (IL-10), a pleiotropic anti-inflammatory cytokine, induces immunosuppression and assists in escape from tumor immune surveillance. Like several other cytokines, IL-10 also can exert dual proliferative and inhibitory effect on breast tumor cells indicating a complex role of IL-10 in breast cancer initiation and progression. In this review, we tried to put together a comprehensive current view on significance of IL-10 in promotion, inhibition, and importance as prognosticator in breast cancer based on in vitro, in vivo, and clinical evidences. For literature collection, we conducted PubMed search with keywords "IL-10" and "breast cancer".

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Section: Il-10 As Prognostic Indicator For Breast Cancermentioning

confidence: 64%

Role of interleukin-10 in breast cancer

Ullah

Changkija

Konwar

2011

Breast Cancer Res Treat

152

113

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“…The T cell proliferation and functions are also inhibited by IL10 [20,21]. Thus, the IL10 produced by the tumour cells is helping them to suppress the host immune response and prevent their detection and elimination by the host immune system [11]. On the other hand, IL10 also exhibits tumour inhibiting antiangiogenic action [6,7].…”

Section: Follow Upmentioning

confidence: 99%

“…A few studies have documented IL10 expression in breast cancer [8][9][10][11]. Serum IL10 concentration is raised in breast cancer patients compared to normal healthy females [12], while other failed to show any association between breast cancer and serum IL10 concentration [13].…”

Section: Introductionmentioning

confidence: 99%

Is Interleukin 10 (IL10) Expression in Breast Cancer a Marker of Poor Prognosis?

Bhattacharjee

Bansal

Nepal

et al. 2016

Indian J Surg Oncol

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Interleukin 10 (IL10) is a poor prognostic marker in several cancers. Its role in breast cancer is not well elucidated. The present study is designed to see the expression of IL10 in breast cancer tissue and to evaluate its correlation with the established markers of prognosis. Sixty female patients who underwent surgery for breast cancer were enrolled for the study. Immediately after surgery, 2-5 g of tumour tissue and similar volume of peritumoural normal breast tissue were collected for IL10 assay. IL10 expression was assayed by immunohistochemistry. IL10 expressing tumours and IL10 non expressing tumours were compared. Chi square/Fisher exact test and student's t test were used to compare the data. p-valueless than 0.05 was considered as statistically significant. Thirty six patients (60 %) of carcinoma breast showed IL 10 expression in tumour tissue as compared to no IL 10 expression in any peritumouralnormal breast tissue (p < 0.01). IL10 expression had statistically significant correlation with locally advanced disease, tumour grade, HER2 + ve tumours and ER-ve, PR-ve, HER2 + ve breast cancer subtypes (p = 0.001, 0.001, 0.001 and 0.01 respectively). No correlation could be found with patient's age, tumour size, tumour histology and ER and PR status. Correlation of IL10 expressing tumours with several established poor prognostic markers of breast cancer may indicate the possible association of IL10 expression with poor prognosis. Large studies with long term follow up are needed to substantiate the association of IL10 with poor prognosis.

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“…These effectors are produced by both tumor and stromal cells, and consequently they affect immune cells on secreting pro-inflammatory factors [43]. In human breast cancer, more regulatory T cells (Tregs) are found, and Tregs might also secrete antiinflammatory cytokines.…”

Section: Tlrs and Breast Cancer Micro-environmentmentioning

confidence: 99%

Toll-like receptors and breast cancer

Sun¹,

Jiang²,

Zhang³

et al. 2016

Integr Cancer Sci Therap

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Toll-like receptors (TLRs) are key receptors in innate immunity and inflammation and are expressed not only in innate immune cells but also in different cancer cells. Increasing evidences demonstrate that TLRs play an important role in the initiation and progression of cancer and metabolism. Currently we have limited therapeutic options to treat patients with advanced non-resectable, recurrent and metastatic breast cancer. An innate immunity-mediated anticancer immunotherapy, alone or in combination with other therapies, represents a promising novel approach. Indeed, some agonists and antagonists of TLRs have been utilized for anticancer immunotherapy in clinical trials. Thus, TLRs are not only involved in immune responses against pathogen infection but also play an important role in cancer immunity, and represent important targets for cancer immunotherapy. In this review, we discuss the recent progress about the role of TLRs in breast cancer development.

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Human breast tumor cells express IL-10 and IL-12p40 transcripts and proteins, but do not produce IL-12p70

Cited by 36 publications

References 80 publications

Role of interleukin-10 in breast cancer

Role of interleukin-10 in breast cancer

Is Interleukin 10 (IL10) Expression in Breast Cancer a Marker of Poor Prognosis?

Toll-like receptors and breast cancer

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