Human-brain ferritin studied by muon spin rotation: a pilot study

Bossoni, L.; Moursel, Laure Grand; Bulk, Marjolein; Simon, Brecht G.; Webb, Andrew; Weerd, Louise van der; Huber, Martina; Carretta, P.; Lascialfari, A.; Oosterkamp, Tjerk H.

doi:10.1088/1361-648x/aa80b3

Cited by 18 publications

(15 citation statements)

References 59 publications

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“…In contrast, the core of pathological ferritin consists primarily of cubic structures, such as magnetite and wustite, and to a lesser extent ferrihydrite, but with no hematite. These conclusions have been confirmed in a recent study [ 25 ], where muon spin rotation was utilized to demonstrate that ferritin particles have a crystalline phase with large magnetocrystalline anisotropy that is compatible with magnetite or maghemite. The altered composition of the ferritin’s mineral core could be associated with pathology.…”

Section: Introductionsupporting

confidence: 52%

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Quantification of Iron Release from Native Ferritin and Magnetoferritin Induced by Vitamins B2 and C

Štrbák

Balejčíková

Kmetova

et al. 2020

IJMS

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Various pathological processes in humans are associated with biogenic iron accumulation and the mineralization of iron oxide nanoparticles, especially magnetite. Ferritin has been proposed as a precursor to pathological magnetite mineralization. This study quantifies spectroscopically the release of ferrous ions from native ferritin and magnetoferritin as a model system for pathological ferritin in the presence of potent natural reducing agents (vitamins C and B2) over time. Ferrous cations are required for the transformation of ferrihydrite (physiological) into a magnetite (pathological) mineral core and are considered toxic at elevated levels. The study shows a significant difference in the reduction and iron release from native ferritin compared to magnetoferritin for both vitamins. The amount of reduced iron formed from a magnetoferritin mineral core is two to five times higher than from native ferritin. Surprisingly, increasing the concentration of the reducing agent affects only iron release from native ferritin. Magnetoferritin cores with different loading factors seem to be insensitive to different concentrations of vitamins. An alternative hypothesis of human tissue magnetite mineralization and the process of iron-induced pathology is proposed. The results could contribute to evidence of the molecular mechanisms of various iron-related pathologies, including neurodegeneration.

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Section: Introductionsupporting

confidence: 52%

“…As previously described, the mineral core of physiological ferritin consists of ferrihydrite, while the mineral core of ferritin associated with pathology consists of magnetite [ 24 , 25 ]. The size of the magnetite nanocrystals ranges from 10 to 70 nm [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Quantification of Iron Release from Native Ferritin and Magnetoferritin Induced by Vitamins B2 and C

Štrbák

Balejčíková

Kmetova

et al. 2020

IJMS

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“…Both scaling to higher energies and cooling of positrons using this mechanism is yet unexplored. Beamdriven plasma acceleration of positrons [27,28] although compact by itself, depends on kilometer-scale GeV RF accelerators. Additionally, obtaining an appropriately spaced drive-witness bunch pair for beam-plasma acceleration methods is technologically di cult.…”

Section: College Of Engineering and Applied Science University Of Comentioning

confidence: 99%

“…work which uses sheath fields driven by kilo-J lasers in metal targets has obtained quasi-mono 10 MeV positrons [26] although with inherently peratures. Both scaling to higher energies and positrons using this mechanism is yet unexplore driven plasma acceleration of positrons [27,28] compact by itself, depends on kilometer-scale accelerators. Additionally, obtaining an app spaced drive-witness bunch pair for beam-plas eration methods is technologically di cult.…”

Section: College Of Engineering and Applied Science University Of Comentioning

confidence: 99%

Schemes of laser muon acceleration: Ultra-short, micron-scale beams

Sahai

Tajima

Shiltsev

2019

Int. J. Mod. Phys. A

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Experimentally accessible schemes of laser muon ([Formula: see text]) acceleration are introduced and modeled using a novel technique of controlled laser-driven post-processing of cascade showers (or pair plasmas). The proposed schemes use propagating structures in plasma, driven as wakefields of femtosecond-scale high-intensity laser, to capture particles of divergent cascade shower of: (a) hadronic type from proton-nucleon or photo-production reactions or, (b) electromagnetic type. Apart from the direct trapping and acceleration of particles of a raw shower in laser-driven plasma, a conditioning stage is proposed to selectively focus only one of the charge states. Not only is the high gradient that is sustained by laser-driven plasma structures well suited for rapid acceleration to extend the lifetime of short-lived muons but their inherent spatiotemporal scales also make possible production of unprecedented ultrashort, micron-scale muon beams. Compact laser muon acceleration schemes hold the promise to open up new avenues for applications.

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“…It has been revealed that muon spin rotation spectroscopy is effective in detecting dissolved oxygen in blood and can be applied to medical treatments for hypoxia [20]. Recently, in a pilot study concerning Alzheimer's disease, the muon spin spectroscopy was used to analyze human-brain ferritin which is an iron storage protein [21]. On the basis of muon spin relaxation spectra on ferritin [22], it was discussed that minerals contained in ferritins from the healthy control and those of the Alzheimer's disease patients were different.…”

Section: Muon Spin Spectroscopic Approach To Monitoring Functions Of mentioning

confidence: 99%

Opportunities for Life Science by Use of Muon Spin Spectroscopy: With a View to Monitoring Protein Functions

Sugawara

2019

Proceedings of the 3rd International Symposium of Quantum Beam Science at Ibaraki University "Quantum Beam Science in Biology A

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Approaches by means of muon spin spectroscopy in the bioscience field began by determining reaction rates of biomacromolecule components with muonium, and then the labelled electron method, using positive muons, was applied to proteins and DNA to monitor the electron transfer processes. Currently, the muon stopping sites in proteins are being determined. In addition, newly started or planned experiments to monitor biological function by use of muon spin spectroscopy have also been introduced.

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Human-brain ferritin studied by muon spin rotation: a pilot study

Cited by 18 publications

References 59 publications

Quantification of Iron Release from Native Ferritin and Magnetoferritin Induced by Vitamins B2 and C

Quantification of Iron Release from Native Ferritin and Magnetoferritin Induced by Vitamins B2 and C

Schemes of laser muon acceleration: Ultra-short, micron-scale beams

Opportunities for Life Science by Use of Muon Spin Spectroscopy: With a View to Monitoring Protein Functions

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