Opportunities for Life Science by Use of Muon Spin Spectroscopy: With a View to Monitoring Protein Functions

Sugawara, Yoko

doi:10.7566/jpscp.25.011008

Cited by 3 publications

(2 citation statements)

References 19 publications

(14 reference statements)

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“…Torikai et al [11] and Hubbard et al [21] reported the electron transfer in DNA [11]. There are other trials on amino acids and peptide bonds to understand the stopping site of muon and electron transfer mechanism [22]. Kiyotani et al [23] also reported some trials to understand the electron and proton transfer in enzime reactions.…”

Section: Sr In Biomolecules 41 Experimentsmentioning

confidence: 99%

A Review of Life Science Studies with Muons

Pant

2021

J. Nep. Phys. Soc.

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Positive muon is a spin half elementary particle lies in the second generation leptons in standard model of particles. It has been used as a sensitive magnetic (spin) probe for study of life and materials. Due to its special characteristics – 100% polarization and asymmetric decay to positron, it provides information about local electronic and spin states of material in which it stops. The asymmetry, relaxation of muon and its charge states in materials provide information about the interested phenomena. For life sciences study, muon can probe the dynamics of electron, proton, ions, H, O2, reaction dynamics, catalytic processes, concentration of molecules, magnetic behaviors, etc. in the biosamples. Here, the applications of positive muon to understand the life related phenomena are reviewed.

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Section: Sr In Biomolecules 41 Experimentsmentioning

confidence: 99%

A Review of Life Science Studies with Muons

Pant

2021

J. Nep. Phys. Soc.

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“…Recently SR method pointed out its application for cancer research [14] and diagnosis of disease [24]. Electron transfer in protein [17,25] and photosynthesis processes have been studying intensively through experimentally and theoretically [26,27]. Besides accelerator produced muon, cosmic muons are also useful for the study of non-destructive analysis of large scale architectures [28] and characterization of materials like study of trapped radioactive materials [29].…”

Section: Applications Of Conventional Muonsmentioning

confidence: 99%

Conventional to slow muon microscopy – a review

Pant¹

2020

BIBECHANA

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Because of special characteristics (fully spin polarized and asymmetric decay to positron), muon acts as sensitive probe to study the local electronic and dynamics of materials. The muon of energy MeV or high, conventional muon, are used to study bulk properties of the materials. For the study of nanoscience, slow muon (20 eV - 30 keV) muon with low energy spread are essential that leads to development of slow muon microscopy. Introduction to muon microscopy, application of conventional muons and need of slow muon beam along with future prospects are briefly discussed. BIBECHANA 17 (2020) 139-145

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Two-component density functional theory for muonic molecules: Inclusion of the electron–positive muon correlation functional

Goli

Shahbazian

2022

The Journal of Chemical Physics

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It is well-known experimentally that the positively charged muon and the muonium atom may bind to molecules and solids, and through muon’s magnetic interaction with unpaired electrons, valuable information on the local environment surrounding the muon is deduced. Theoretical understanding of the structure and properties of resulting muonic species requires accurate and efficient quantum mechanical computational methodologies. In this paper, the two-component density functional theory (TC-DFT), as a first principles method, which treats electrons and the positive muon on an equal footing as quantum particles, is introduced and implemented computationally. The main ingredient of this theory, apart from the electronic exchange–correlation functional, is the electron–positive muon correlation functional that is foreign to the purely electronic DFT. A Wigner-type local electron–positive muon correlation functional, termed eμc-1, is proposed in this paper and its capability is demonstrated through its computational application to a benchmark set of muonic organic molecules. The TC-DFT equations containing eμc-1 are not only capable of predicting the muon’s binding site correctly, but they also reproduce muon’s zero-point vibrational energies and the muonic densities much more accurately than the TC-DFT equations lacking eμc-1. Thus, this study sets the stage for developing accurate electron–positive muon functionals, which can be used within the context of the TC-DFT to elucidate the intricate interaction of the positive muon with complex molecular systems.

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Opportunities for Life Science by Use of Muon Spin Spectroscopy: With a View to Monitoring Protein Functions

Cited by 3 publications

References 19 publications

A Review of Life Science Studies with Muons

A Review of Life Science Studies with Muons

Conventional to slow muon microscopy – a review

Two-component density functional theory for muonic molecules: Inclusion of the electron–positive muon correlation functional

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