Human Body Rhythms in the Development of Non-Invasive Methods of Closed-Loop Adaptive Neurostimulation

Федотчев, А. И.; Парин, С. Б.; Polevaya, S. A.; Zemlianaia, Anna

doi:10.3390/jpm11050437

Cited by 8 publications

(5 citation statements)

References 44 publications

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“…40 [53][54][55], Serenade No. 13 [56,57], and Fur Elise [58][59][60][61]. The second category of stimulus consisted of Indian Classical Music, like Raga Anand Bharavi [62,63], Raga Yaman [64,65], and Raga Mohanam [66,67].…”

Section: Stimulimentioning

confidence: 99%

Preventing fear return in humans: Music-based intervention during reactivation-extinction paradigm

Verma,

Mitra,

Khamaj

et al. 2024

PLoS ONE

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In several research studies, the reactivation extinction paradigm did not effectively prevent the return of fear if administered without any intervention technique. Therefore, in this study, the authors hypothesized that playing music (high valence, low arousal) during the reconsolidation window may be a viable intervention technique for eliminating fear-related responses. A three-day auditory differential fear conditioning paradigm was used to establish fear conditioning. Participants were randomly assigned into three groups, i.e., one control group, standard extinction (SE), and two experimental groups, reactivation extinction Group (RE) and music reactivation extinction (MRE), of twenty participants in each group. Day 1 included the habituation and fear acquisition phases; on Day 2 (after 24 hours), the intervention was conducted, and re-extinction took place on Day 3. Skin conductance responses were used as the primary outcome measure. Results indicated that the MRE group was more effective in reducing fear response than the RE and SE groups in the re-extinction phase. Furthermore, there was no significant difference observed between SE and RE groups. This is the first study known to demonstrate the effectiveness of music intervention in preventing the return of fear in a healthy individual. Therefore, it might also be employed as an intervention strategy (non-pharmacological approach) for military veterans, in emotion regulation, those diagnosed with post-traumatic stress disorder, and those suffering from specific phobias.

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Section: Stimulimentioning

confidence: 99%

Preventing fear return in humans: Music-based intervention during reactivation-extinction paradigm

Verma,

Mitra,

Khamaj

et al. 2024

PLoS ONE

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“…The closed-loop system can effectively combine the time-domain result parameters with the space-domain result parameters and adjust the parameter combination (intensity, frequency, and electrode position) of the stimulation system in real time to achieve accurate neuromodulation. In the noninvasive field, closed-loop transcranial direct current stimulation (tDCS) and EEG have been used to explore personalized cognitive training and rehabilitation technology and limb function recovery after stroke [ 117 , 118 ]. The closed-loop neural control system enables the selection of the best control strategy and the simultaneous optimization of the input stimulation and output effect with its adaptive control process and visualization of the control effect.…”

Section: The Closed-loop System and Personalized Digital Twin Brain (...mentioning

confidence: 99%

Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review

et al. 2023

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We review the research progress on noninvasive neural regulatory systems through system design and theoretical guidance. We provide an overview of the development history of noninvasive neuromodulation technology, focusing on system design. We also discuss typical cases of neuromodulation that use modern noninvasive electrical stimulation and the main limitations associated with this technology. In addition, we propose a closed-loop system design solution of the “time domain”, “space domain”, and “multi-electrode combination”. For theoretical guidance, this paper provides an overview of the “digital brain” development process used for noninvasive electrical-stimulation-targeted modeling and the development of “digital human” programs in various countries. We also summarize the core problems of the existing “digital brain” used for noninvasive electrical-stimulation-targeted modeling according to the existing achievements and propose segmenting the tissue. For this, the tissue parameters of a multimodal image obtained from a fresh cadaver were considered as an index. The digital projection of the multimodal image of the brain of a living individual was implemented, following which the segmented tissues could be reconstructed to obtain a “digital twin brain” model with personalized tissue structure differences. The “closed-loop system” and “personalized digital twin brain” not only enable the noninvasive electrical stimulation of neuromodulation to achieve the visualization of the results and adaptive regulation of the stimulation parameters but also enable the system to have individual differences and more accurate stimulation.

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“…Closed-loop systems are designed to continuously monitor a patient's brain activity and adjust stimulation parameters accordingly, thus potentially providing personalized therapy that is both efficient and automatic [35]. Compared to traditional openloop methods, closed-loop neurostimulation may significantly enhance clinical outcomes, reduce side effects, and boost overall efficacy [36,37]. For example, the feasibility of a closedloop system was demonstrated in a proof-of-concept study involving six healthy subjects, considering the power distribution of the electroencephalogram (EEG) spectrum [38].…”

Section: Introductionmentioning

confidence: 99%

Closed-Loop Transcranial Electrical Neurostimulation for Sustained Attention Enhancement: A Pilot Study towards Personalized Intervention Strategies

Caravati,

Barbeni,

Chiarion

et al. 2024

Bioengineering

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Sustained attention is pivotal for tasks like studying and working for which focus and low distractions are necessary for peak productivity. This study explores the effectiveness of adaptive transcranial direct current stimulation (tDCS) in either the frontal or parietal region to enhance sustained attention. The research involved ten healthy university students performing the Continuous Performance Task-AX (AX-CPT) while receiving either frontal or parietal tDCS. The study comprised three phases. First, we acquired the electroencephalography (EEG) signal to identify the most suitable metrics related to attention states. Among different spectral and complexity metrics computed on 3 s epochs of EEG, the Fuzzy Entropy and Multiscale Sample Entropy Index of frontal channels were selected. Secondly, we assessed how tDCS at a fixed 1.0 mA current affects attentional performance. Finally, a real-time experiment involving continuous metric monitoring allowed personalized dynamic optimization of the current amplitude and stimulation site (frontal or parietal). The findings reveal statistically significant improvements in mean accuracy (94.04 vs. 90.82%) and reaction times (262.93 vs. 302.03 ms) with the adaptive tDCS compared to a non-stimulation condition. Average reaction times were statistically shorter during adaptive stimulation compared to a fixed current amplitude condition (262.93 vs. 283.56 ms), while mean accuracy stayed similar (94.04 vs. 93.36%, improvement not statistically significant). Despite the limited number of subjects, this work points out the promising potential of adaptive tDCS as a tailored treatment for enhancing sustained attention.

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Human Body Rhythms in the Development of Non-Invasive Methods of Closed-Loop Adaptive Neurostimulation

Cited by 8 publications

References 44 publications

Preventing fear return in humans: Music-based intervention during reactivation-extinction paradigm

Preventing fear return in humans: Music-based intervention during reactivation-extinction paradigm

Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review

Closed-Loop Transcranial Electrical Neurostimulation for Sustained Attention Enhancement: A Pilot Study towards Personalized Intervention Strategies

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