Human bocavirus infection in children with acute gastroenteritis in Japan and Thailand

Pham, Ngan Thi Kim; Trinh, Quang Duy; Chan-it, Wisoot; Khamrin, Pattara; Nishimura, Shigeyuki; Sugita, Kumiko; Maneekarn, Niwat; Okitsu, Shoko; Mizuguchi, Masashi; Ushijima, Hiroshi

doi:10.1002/jmv.21876

Cited by 24 publications

(23 citation statements)

References 33 publications

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“…HBoV detection in stool samples from patients with acute gastroenteritis has been reported to range from 2% to 20% [21][22][23][24]. In the present study, about 10% of the tested samples were positive for HBoV-1 DNA by qPCR, which was confirmed by an independent amplification of another genomic region with sequence analysis of the VP1 gene.…”

Section: Discussionsupporting

confidence: 68%

Viral load of human bocavirus-1 in stools from children with viral diarrhoea in Paraguay

et al. 2013

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Since their discovery, four species of human bocavirus (HBoV) have been described in patients with respiratory and gastrointestinal diseases. However, a clear causal association between HBoV-1 and gastroenteritis has not been demonstrated. In this study, we describe the detection and quantification of HBoV-1 in stools from children with acute non-bacterial gastroenteritis using quantitative polymerase chain reaction. HBoV-1 genome was detected in 10.6% of stools with frequent association with rotavirus and norovirus. The median of HBoV-1 viral load was 1.88 × 104 genome/ml, lower than previously shown in secretions of patients with respiratory infections, without any obvious association between high viral load and presence of HBoV as single agent. Thus, although HBoV-1 was frequently detected in these patients, there is no clear causal association of this agent with diarrhoea. Indeed, HBoV-1 DNA in stools of patients with gastroenteritis without respiratory symptoms may be a remnant of previous infections or associated with prolonged shedding of virus in the respiratory or digestive tracts.

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Section: Discussionsupporting

confidence: 68%

Viral load of human bocavirus-1 in stools from children with viral diarrhoea in Paraguay

et al. 2013

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“…The reports on HBoV in Africa, other developing countries, and worldwide in individuals suffering from respiratory tract infection 78% (55/70) were higher compared to those suffering from gastroenteritis 21% (15/70) (Tables 1, 2, and 3). This could be due to the fact that most studies focused on HBoV in respiratory tract infection since its discovery in 2005 [28,33,36,71]. However recent studies are increasingly detecting HBoV in individuals suffering from diarrheal diseases due to the presence of the virus in stool samples of individuals suffering from gastroenteritis [37,[72][73][74].…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Human Bocavirus in Africa and Other Developing Countries between 2005 and 2016: A Potential Emerging Viral Pathogen for Diarrhea

Rikhotso

Kabue

Ledwaba

et al. 2018

Journal of Tropical Medicine

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Background Human Bocavirus (HBoV) is an emerging virus discovered in 2005 from individuals suffering gastroenteritis and respiratory tract infections. Numerous studies related to the epidemiology and pathogenesis of HBoV have been conducted worldwide. This review reports on HBoV studies in individuals with acute gastroenteritis, with and without respiratory tract infections in Africa between 2005 and 2016. Material and Method The search engines of PubMed, Google Scholar, and Embase database for published articles of HBoV were used to obtain data between 2005 and 2016. The search words included were as follows: studies performed in Africa or/other developing countries or/worldwide; studies for the detection of HBoV in patients with/without diarrhea and respiratory tract infection; studies using standardized laboratory techniques for detection. Results The search yielded a total of 756 publications with 70 studies meeting the inclusion criteria. Studies included children and individuals of all age groups. HBoV prevalence in Africa was 13% in individuals suffering gastroenteritis with/without respiratory tract infection. Conclusion Reports suggest that HBoV infections are increasingly being recognized worldwide. Therefore, surveillance of individuals suffering from infections in Africa is required to monitor the prevalence of HBoV and help understand the role of HBoV in individuals suffering from gastroenteritis with/without respiratory tract infection.

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“…The virus has also been found in stool specimens from patients with gastrointestinal illness. 38,39 Therefore, additional evidence and studies are needed throughout the world to gain a better understanding of this virus.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China

Zhang

et al. 2014

International Journal of Infectious Diseases

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Human bocavirus infection in children with acute gastroenteritis in Japan and Thailand

Cited by 24 publications

References 33 publications

Viral load of human bocavirus-1 in stools from children with viral diarrhoea in Paraguay

Viral load of human bocavirus-1 in stools from children with viral diarrhoea in Paraguay

Prevalence of Human Bocavirus in Africa and Other Developing Countries between 2005 and 2016: A Potential Emerging Viral Pathogen for Diarrhea

Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China

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