Human Bocavirus Infection among Children, Jordan

Kaplan, Nasser M.; Dove, Winifred; Abu-Zeid, Ahmad F.; Shamoon, Hiyam E.; Abd-Eldayem, Sawsan A.

doi:10.3201/eid1209.060417

Cited by 90 publications

(109 citation statements)

References 14 publications

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“…1). Previous studies detected HBoV mainly in children less than 5 years old and mostly in infants less than 2 years old (Choi et al, 2006;Kaplan et al, 2006;Kesebir et al, 2006;Kleines et al, 2007;Brieu et al, 2008;Canducci et al, 2008;Cilla et al, 2008). However, a recent report (Guido et al, 2011) and the present work confirm that HBoV1 is also a frequent virus in adults with respiratory disease.…”

Section: Resultscontrasting

confidence: 49%

“…However, considering the high frequency of HBoV1 detection in infants younger than 1 year and during the fall-winter period, plus the circulation pattern of RSV (Leung et al, 2005), a high rate of HBoV1-RSV co-infection is most likely. Elevated percentages of RSV-HBoV1 co-infections have been observed by others and RSV is commonly cited as the most frequent respiratory virus in co-infection with HBoV1 (Kaplan et al, 2006;Weissbrich et al, 2006;Gerna et al, 2007;Cilla et al, 2008;Pilger et al, 2011). Interestingly, we did not find co-infections in HBoV + samples from adults.…”

Section: Resultscontrasting

confidence: 40%

“…With a ubiquitous distribution, the presence of HBoV DNA has been reported mostly in children with ARI in a variable range from 1.5 to 19 % (Allander, 2008), although recently even higher prevalence (33 %) has been observed in ill children (Martin et al, 2010). Although the virus is associated with ARI, the elevated rates of coinfection with other respiratory viruses with well-established pathogenic potential (Kaplan et al, 2006;Allander et al, 2007;Fry et al, 2007; Gerna et al, 2007;Kleines et al, 2007; Christensen et al, 2008 Christensen et al, , 2010Cilla et al, 2008;Pilger et al, 2011), the detection in asymptomatic individuals (Christensen et al, 2010) and the possibility of a persistent infection (Martin et al, 2010) make it difficult to allocate a causative role for HBoV in respiratory disease. Not only is the aetiological capacity of HBoV under investigation, but the natural history of the infection is still unknown.…”

Section: Introductionmentioning

confidence: 99%

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High frequency of human bocavirus 1 DNA in infants and adults with lower acute respiratory infection

Ghietto

Cámara

et al. 2012

Journal of Medical Microbiology

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Instituto de Virología 'Dr J. M. Vanella', Facultad de Ciencias Mé dicas, Universidad Nacional de Có rdoba, ArgentinaHuman bocavirus (HBoV) is a parvovirus with a possible aetiological role in respiratory disease that is currently under investigation. We detected HBoV1 in children and adults hospitalized with acute disease of the lower respiratory tract. HBoV genome was detected by PCR in nasopharyngeal swabs collected from 75 patients aged 0-89 years during 2010. HBoV was found in 17/75 (22.7 %) patients, 64.7 % of them infants younger than 1 year old and 29.4 % adults older than 30 years [the bimodal age distribution among HBoV-positive (HBoV + ) patients was statistically significant, P,0.001]. Of all HBoV + cases, 35.3 % were co-infected; all coinfections occurred in children (¡13 years old) and 83.3 % of them were HBoV-respiratory syncytial virus (RSV) co-infections. Among infants younger than 1 year, 50 % HBoV + specimens were co-infected, all of them with RSV. The rate of co-infection in infants was significantly higher compared to the frequency of co-infection in the whole cohort (P50.003). The results suggest that HBoV1 is involved in acute respiratory disease. Interplay between HBoV1 and RSV cannot be discarded as a cause of elevated percentages of co-detections in infants. INTRODUCTIONHuman bocavirus (HBoV) is a parvovirus first identified in 2005 in nasopharyngeal aspirates of children with lower respiratory tract infection (Allander et al., 2005). Since then, it has been associated with upper and lower acute respiratory infection (ARI), a leading cause of acute illnesses worldwide and the most important cause of mortality in infants and young children and disabilityadjusted life-years lost in developing countries (Simoes et al., 2006; WHO, 2009). To date, four species of HBoV have been proposed, and the name human bocavirus 1 (HBoV1) was suggested for the originally discovered virus. HBoV1 is linked to respiratory disease, while it is believed that HBoV2-4 are associated with gastroenteritis (Kapoor et al., 2010). With a ubiquitous distribution, the presence of HBoV DNA has been reported mostly in children with ARI in a variable range from 1.5 to 19 % (Allander, 2008), although recently even higher prevalence (33 %) has been observed in ill children (Martin et al., 2010). Although the virus is associated with ARI, the elevated rates of coinfection with other respiratory viruses with well-established pathogenic potential (Kaplan et al., 2006;Allander et al., 2007;Fry et al., 2007; Gerna et al., 2007;Kleines et al., 2007; Christensen et al., 2008 Christensen et al., , 2010Cilla et al., 2008;Pilger et al., 2011), the detection in asymptomatic individuals (Christensen et al., 2010) and the possibility of a persistent infection (Martin et al., 2010) make it difficult to allocate a causative role for HBoV in respiratory disease. Not only is the aetiological capacity of HBoV under investigation, but the natural history of the infection is still unknown. In addition, the impact of HBoV on the global epid...

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Section: Resultscontrasting

confidence: 49%

Section: Resultscontrasting

confidence: 40%

Section: Introductionmentioning

confidence: 99%

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High frequency of human bocavirus 1 DNA in infants and adults with lower acute respiratory infection

Ghietto

Cámara

et al. 2012

Journal of Medical Microbiology

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“…In the majority of previous studies, the coinfection rates ranged from 18-72% (Allander et al 2005, Kaplan et al 2006. RSV was the most prevalent pathogen associated with hBoV in all studies, including ours.…”

Section: Discussionmentioning

confidence: 97%

“…According to the literature, the prevalence of hBoV infection among hospitalized children with respiratory tract infection ranges between 1.5-18.3% (Bastien et al 2006, Kaplan et al 2006, Allander et al 2007). In our study, we found a prevalence of 13.2%, which is one of the highest reported so far.…”

Section: Discussionmentioning

confidence: 99%

Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil

Pilger¹,

Cantarelli

Amantéa

et al. 2011

Mem. Inst. Oswaldo Cruz

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The introduction of newer molecular methods has led to the discovery of new respiratory viruses, such as human metapneumovirus (hMPV) and human bocavirus (hBoV), in respiratory tract specimens. We have studied the occurrence of hMPV and hBoV in the Porto Alegre (PA) metropolitan area, one of the southernmost cities of Brazil, evaluating children with suspected lower respiratory tract infection from May 2007-June 2008. A real-time polymerase chain reaction method was used for amplification and detection of hMPV and hBoV and to evaluate coinfections with respiratory syncytial virus (RSV), influenza A and B, parainfluenza 1, 2 and 3, human rhinovirus and human adenovirus. Of the 455 nasopharyngeal aspirates tested, hMPV was detected in 14.5% of samples and hBoV in 13.2%. A unique causative viral agent was identified in 46.2% samples and the coinfection rate was 43.7%. For hBoV, 98.3% of all positive samples were from patients with mixed infections. Similarly, 84.8% of all hMPV-positive results were also observed in mixed infections. Both hBoV and hMPV usually appeared with RSV. In summary, this is the first confirmation that hMPV and hBoV circulate in PA; this provides evidence of frequent involvement of both viruses in children with clinical signs of acute viral respiratory tract infection, although they mainly appeared as coinfection agents

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Molecular epidemiology and disease severity of respiratory syncytial virus in relation to other potential pathogens in children hospitalized with acute respiratory infection in Jordan

Kaplan

Dove

Abd-Eldayem

et al. 2007

Journal of Medical Virology

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Human respiratory syncytial virus (HRSV) is the major viral cause of acute lower respiratory tract infections in children. Few data about the molecular epidemiology of respiratory syncytial virus in developing countries, such as Jordan, are available. The frequency and severity of infections caused by HRSV were assessed in hospitalized Jordanian children <5 years of age compared with other potential etiological agents. Overall a potential pathogen was detected in 78% (254/326) of the children. HRSV was detected in 43% (140/326) of the nasopharyngeal aspirates. HRSV was found more frequently during the winter (January/February), being less frequent or negligible by spring (March/April). Analysis of 135 HRSV-positive strains using restriction fragment length polymorphism showed that 94 (70%) belonged to subgroup A, and 41 (30%) to subgroup B. There were also two cases of mixed genotypic infection. Only four of the six previously described N genotypes were detected with NP4 predominating. There were no associations between subgroup or N-genogroup and disease severity. HRSV was significantly associated with more severe acute respiratory infection and the median age of children with HRSV was lower than for those without. Next in order of frequency were adenovirus (116/312: 37%), human bocavirus (57/312: 18%), rhinovirus (36/325: 11%), Chlamydia spp. (14/312: 4.5%), human metapneumovirus (8/326: 2.5%), human coronavirus NL63 (4/325: 1.2%), and influenza A virus (2/323: 0.6%). Influenza B; parainfluenza viruses 1-4, human coronavirus HKU1 and Mycoplasma pneumoniae were not detected.

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Human Bocavirus Infection among Children, Jordan

Cited by 90 publications

References 14 publications

High frequency of human bocavirus 1 DNA in infants and adults with lower acute respiratory infection

High frequency of human bocavirus 1 DNA in infants and adults with lower acute respiratory infection

Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil

Molecular epidemiology and disease severity of respiratory syncytial virus in relation to other potential pathogens in children hospitalized with acute respiratory infection in Jordan

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