Molecular epidemiology and disease severity of respiratory syncytial virus in relation to other potential pathogens in children hospitalized with acute respiratory infection in Jordan

Kaplan, Nasser M.; Dove, Winifred; Abd-Eldayem, Sawsan A.; Abu-Zeid, Ahmad F.; Shamoon, Hiyam E.; Hart, C. A.

doi:10.1002/jmv.21067

Cited by 67 publications

(72 citation statements)

References 42 publications

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“…This is the first report on the incidence of hMPV-related infections in children in Qatar, though studies have demonstrated the presence of hMPV in the other Middle Eastern countries [32][33][34]. Our data demonstrate a high incidence of the virus in children 6 months to 5 years of age with respiratory tract infections.…”

Section: Resultssupporting

confidence: 45%

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Althani¹,

Azzam

Abboubaker

et al. 2010

Future Virol.

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Aim: The human metapneumovirus (hMPV) has been recently discovered as an etiological agent of acute respiratory infections in infants and children, with similar clinical symptoms to those caused by respiratory syncytial virus. The aim of this study was to determine the prevalence of hMPV and its potential role as a causative agent of respiratory tract infections in children in Qatar. Methods: In the present study, we examined 84 nasopharyngeal aspirates from children with respiratory tract infections, presenting at Al-Saad Pediatric Emergency Center in Doha, Qatar, as outpatients, for the presence of respiratory viruses. Results: A total of 56 out of 84 (66.7%) cases were positive for the presence of respiratory viruses. Out of the 56 positive cases 54 (96%) contained hMPV; whereas 12 out of 56 (21.4%) contained human parainfluenza virus. A total of 14 out of 56 of the positive patients were infected with more than one virus. hMPV was in samples infected with one or more respiratory tract infection viruses and was the most frequently isolated virus from infants less than 6 months of age. Conclusion: This is the first report demonstrating the prevalence of hMPV in children suffering from respiratory tract infections in Qatar. Detection of this virus may have significant clinical implications in this patient population in Qatar.

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Section: Resultssupporting

confidence: 45%

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Althani¹,

Azzam

Abboubaker

et al. 2010

Future Virol.

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“…There is little information from other studies conducted in the same area. However, previous studies conducted in Jordan found a high detection rate of RSV and adenovirus but very low rates of influenza virus [13].…”

Section: Discussionmentioning

confidence: 80%

Chlamydophila pneumoniae, Mycoplasma pneumoniae, and influenza in children with respiratory infections in Alexandria, Egypt

Grassi

Mancini

Ciervo

et al. 2014

J Infect Dev Ctries

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Introduction: Acute respiratory infections (ARI) are the leading cause of pediatric morbidity and mortality worldwide. Information about etiological agents of ARI in developing countries is still limited. Methodology: Throat swabs collected from children hospitalized with ARI between December 2009 and May 2010 were investigated for Chlamydophila pneumoniae, Mycoplasma pneumoniae, and influenza viruses by molecular analyses. Results: This study conducted in Alexandria, Egypt, was designed to determine the prevalence of several microorganisms in 156 children hospitalized with ARI. Overall, samples from 76 individuals (49%) were found to be positive for at least one pathogen, and 10 of them were positive for two agents. C. pneumoniae was the most commonly detected agent, followed by M. pneumonia and H1N1 pandemic influenza virus. Positivity for C. pneumoniae was associated with colder months and mild disease of the upper respiratory tract such as laryngitis. Conclusions: Further studies are needed to identify other possible agents of ARI (e.g., RSV, adenoviruses, other bacterial infections) in this population and to better understand the causal role of atypical bacteria detected in respiratory samples.

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“…The percentages of CAP cases with C. pneumoniae infection in these reports ranged from 0% to 23%, as assessed by PCR or IgM level determination [19,20]. Here, the prevalence of C. pneumoniae acute infection in Jordanian CAP cases was 16.3%.…”

Section: Discussionmentioning

confidence: 94%

“…Al-Ali et al detected C. pneumoniae IgM antibodies in 23% and 14% of hospitalized adults and children, respectively [19]. Another report confirmed the presence of Chlamydia DNA in 4.5% of Jordanian children younger than five years of age and hospitalized with acute respiratory infection, based on Chlamydia spp.-specific polymerase chain reaction (PCR) for nasopharyngeal samples [20]. However, a more recent study could not find C. pneumoniae DNA by multiplex PCR in throat and nasal swabs collected from Jordanian children younger than two years of age and hospitalized with acute respiratory disease (A. Shehabi, personal communication, November 13, 2014).…”

Section: Introductionmentioning

confidence: 99%

Role of Chlamydia pneumoniae in community-acquired pneumonia in hospitalized Jordanian adults

Al-Aydie

Obeidat

Al-Younes

2016

J Infect Dev Ctries

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Introduction: This study investigated the role of Chlamydia pneumoniae in the etiology of community-acquired pneumonia (CAP) in Jordanian adults. Methodology: Eighty hospitalized CAP patients and 110 healthy adults were enrolled. Overall prevalences of C. pneumoniae IgG antibodies in sera and the rate of acute infection were estimated, using the microimmunofluorescence method (MIF), at titers of 1:16 and 1:512, respectively. Moreover, a nested polymerase chain reaction (PCR) was used to detect C. pneumoniae DNA in nasopharyngeal and blood Buffy coat samples. Results: Overall chlamydial IgG prevalence was higher in CAP cases than controls (70% versus 61.8%). Similarly, higher rate of acute infection was found in patients than in controls (16.3% versus 5.5%). By focusing on subjects testing positive at 1:16, acute infection was detectable in 23.2% of CAP cases, compared with 8.8% of seropositive controls. Chlamydial DNA was confirmed in 8.2% and 8.8% of nasopharyngeal specimens from controls and patients, respectively. Moreover, 10.9% and 7.5% of Buffy coats from controls and cases, respectively, were PCR-positive. When performances of both assays for detection of the pathogen were assessed, the sensitivities of MIF and PCR were low and comparable. However, MIF demonstrated higher specificity, positive predictive value, and negative predictive value than PCR. Conclusions: MIF-based data indicate that C. pneumoniae could be a potential causal agent of CAP in Jordan. This study may serve as a basis to elucidate the exact role C. pneumoniae and other co-infecting pathogens in the etiology of respiratory tract disease.

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Molecular epidemiology and disease severity of respiratory syncytial virus in relation to other potential pathogens in children hospitalized with acute respiratory infection in Jordan

Cited by 67 publications

References 42 publications

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Chlamydophila pneumoniae, Mycoplasma pneumoniae, and influenza in children with respiratory infections in Alexandria, Egypt

Role of Chlamydia pneumoniae in community-acquired pneumonia in hospitalized Jordanian adults

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