Human autonomic responses to blood donation

Zöllei, Éva; Paprika, Dóra; Makra, Péter; Gingl, Zoltán; Vezendi, K; Rudas, László

doi:10.1016/j.autneu.2003.10.003

Cited by 29 publications

(38 citation statements)

References 20 publications

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“…Even the mean low frequency SP-RR interval phase remained basically unaltered around -45 to -56 degrees. Although this is not decisive evidence regarding the extent of baroreflex involvement, these phases are compatible with arterial baroreflex response delay (9,35). Mason et al (19) recently reported a series of experiments with yoga beginners where they tested 6/minute breathing with both identical (5:5) and 3:7 inspiration-expiration ratios.…”

Section: Discussionmentioning

confidence: 73%

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Hemodynamic effects of slow breathing: Does the pattern matter beyond the rate?

Paprika

Gingl

Rudas

et al. 2014

Acta Physiologica Hungarica

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Purpose: Patterned breathing allows standardized serial measurements of heart rate variability and baroreflex indices. The slow breathing augments these parameters, and regular exercises, including yoga breathing practices with even respiratory rates have long-term beneficial effects in cardiovascular diseases. The role of temporization of breathing phases, i.e. the ratio of expiration to inspiration, is not known. In order to characterize the hemodynamic and autonomic responses during varying breathing phases 27 volunteers performed three short breathing sessions at 6/minutes frequency with 5:5, 3:7 and 7:3 inspiration expiration ratios. Results: The immediate responses in arterial pressure and heart rate were negligible. The time domain parameters of heart rate variability (SDRR, PNN50, RMSSD) increased significantly with patterned breathing. So did the spontaneous baroreflex gain of increasing sequences (up-BRS, from 12 ± 7 to 17 ± 10 ms/mmHg, p < 0.05), and the cross-spectral low frequency gain, the LF alpha (from 11 ± 7 to 15 ± 7 ms/mmHg, p < 0.05). None of these parameters differed significantly from each other while using any of tested inspiratory-expiratory patterns. Conclusion: The major determinant of autonomic responses induced by slow patterned breathing is the breathing rate itself. From our observations, it follows that slow breathing exercises performed either with diagnostic or therapeutic purpose could be simplified, allowing more extensive investigations.

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Section: Discussionmentioning

confidence: 73%

“…The low frequency range limit was set at 0.05-0.15 Hz and low frequency cross-spectral alpha index was calculated as the square root of the ratios of SAP and RRI powers (LF alpha). Phase angles between RRI and SAP fluctuations were also determined in the low frequency range (35).…”

Section: Methodsmentioning

confidence: 99%

Hemodynamic effects of slow breathing: Does the pattern matter beyond the rate?

Paprika

Gingl

Rudas

et al. 2014

Acta Physiologica Hungarica

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“…24) In contrast, another study reported that the HF spectra decreased in response to acute blood loss, which suggests decreased vagal activity. 28) Finally, another group recently reported that the HRV is a good indicator of the change in autonomic nervous system activity during hemorrhage. 29) In this report, central volume in the body is well reflected the changes in the HRV indices.…”

Section: Discussionmentioning

confidence: 99%

Characteristic Changes in Heart Rate Variability Indices during Hemorrhagic Shock, and Effect of Liposome‐Encapsulated Hemoglobin in Rats

Nogami

Takase

Kinoshita

et al. 2010

Journal of Arrhythmia

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Many compensatory mechanisms exit in hemorrhagic shock (HS). To characterize the efficacy of the new artificial oxygen carrier, liposome‐encapsulated hemoglobin (LHb), HS was induced by withdrawing 20% of the total blood volume from rats. Rats received one of five interventions: LHb resuscitation (LHb‐G, n = 7), normal saline (Saline‐G, n = 7), shed autologous blood (SAB‐G, n = 7), volume expander of 5% albumin (Albumin‐G, n = 7), or no treatment (Sham‐G, n = 7). Heart rate variability (HRV) indices were measured, including low frequency (LF, 0.10–0.60 Hz), high frequency (HF, 0.60–2.00 Hz), and the ratio of LF to HF (LF/HF). LF and LF/HF following HS were lower in the LHb‐G and SAB‐G groups when compared with the Saline‐G, Albumin‐G and Sham‐G groups. LF and LF/HF following HS in the LHb‐G group were comparable with that of the SAB‐G group. These data demonstrate that HS‐induced changes can be attenuated by resuscitation with LHb as well as SAB. LHb could be used as a substitute for blood transfusion for HS.

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“…3). Only a few previous studies have evaluated HRV during blood donation in humans (Triedman et al 1993;Zöllei et al 2004;Middleton et al 2008). These studies reported that due to blood loss (350-500 mL), the HF power and LF/HF ratio have a tendency to decrease (Triedman et al 1993;Zöllei et al 2004;Middleton et al 2008) and increase (Middleton et al 2008).…”

Section: Cardiovascular Dynamics and Autonomic Regulation During Bloomentioning

confidence: 99%

“…HbA1c, hemoglobin A1c; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol. (Triedman et al 1993;Kosowsky et al 2002;Haberthür et al 2003;Zöllei et al 2004). According to the five classes of hemorrhagic shock, the quantity of blood volume loss in the present study constitutes less than a class I hemorrhage (15% of the circulating blood volume) (American College of Surgeons Committee on Trauma 2012).…”

Section: Cardiovascular Dynamics and Autonomic Regulation During Bloomentioning

confidence: 99%

Elevated HbA1c Levels Are Associated with the Blunted Autonomic Response Assessed by Heart Rate Variability during Blood Volume Reduction

Kamakura

Maruyama

2016

Tohoku J. Exp. Med.

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A high glycemic status increases the risk for autonomic dysfunction and cardiovascular failure. The aim of this study was to investigate time-dependent changes in the autonomic response and cardiovascular dynamics and the association between the level of hemoglobin A1c (HbA1c) and autonomic response during blood volume reduction. The study population consisted of 26 preoperative participants who were scheduled for autologous blood donation (200-400 mL of whole blood) for intraoperative or postoperative use. These participants without circulatory, respiratory, or brain disease and diabetes mellitus were grouped according to their HbA1c levels: < 6.5% (n = 18) and ≥ 6.5% (n = 8). We measured blood pressure (BP) and analyzed heart rate variability (HRV) to quantify cardiac autonomic regulation throughout blood donation. During blood volume reduction, which was about 10% of the circulating blood volume, the BP and heart rate varied within normal ranges in both groups. The high-frequency (HF) component, an index of parasympathetic nerve activity, and the ratio of low-frequency (LF) to HF components (LF/HF), an index of sympathetic nerve activity, significantly decreased and increased with the progression of blood volume reduction, respectively, in the HbA1c < 6.5% group. In contrast, in the HbA1c ≥ 6.5% group, the HF component did not significantly change, and the increase in the LF/HF ratio was delayed. Time-dependent changes in HRV were related to blood volume reduction only in the HbA1c < 6.5% group. Thus, elevated HbA1c levels are associated with the decrease in the autonomic response induced by blood volume reduction.

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Human autonomic responses to blood donation

Cited by 29 publications

References 20 publications

Hemodynamic effects of slow breathing: Does the pattern matter beyond the rate?

Hemodynamic effects of slow breathing: Does the pattern matter beyond the rate?

Characteristic Changes in Heart Rate Variability Indices during Hemorrhagic Shock, and Effect of Liposome‐Encapsulated Hemoglobin in Rats

Elevated HbA1c Levels Are Associated with the Blunted Autonomic Response Assessed by Heart Rate Variability during Blood Volume Reduction

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