Human Auditory Steady State Evoked Potentials during Sleep

Linden, R D; Campbell, Kenneth C.; Hamel, Gilles; Picton, Terence W.

doi:10.1097/00003446-198505000-00008

Cited by 126 publications

(49 citation statements)

References 2 publications

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“…Spontaneously occurring gamma oscillations vary according to behavioral state, being higher during wakefulness than during NREM sleep (12) and reduced in anesthesia (13). Similarly, the ASSR power is reduced by about 50% during sleep (28) and is abolished by deep anesthesia (42). Although other parts of the ARAS, such as the thalamus (3), likely are important, our results suggest that BF PV neurons are involved in state-dependent control of GBO.…”

Section: Discussionmentioning

confidence: 69%

“…However, this hypothesis has not been tested directly. Thus, here we tested the effect of selective excitation of BF PV neurons on the cortical EEG and the effect of selective inhibition on the 40-Hz auditory steady-state response (ASSR), a test of the ability of the cortex to generate GBO (26) widely used in clinical studies of anesthesia (27), hearing loss (28), and schizophrenia (5,29).…”

Section: Significancementioning

confidence: 99%

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Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

Kim

Thankachan

Mckenna

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

263

256

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Cortical gamma band oscillations (GBO, 30–80 Hz, typically ∼40 Hz) are involved in higher cognitive functions such as feature binding, attention, and working memory. GBO abnormalities are a feature of several neuropsychiatric disorders associated with dysfunction of cortical fast-spiking interneurons containing the calcium-binding protein parvalbumin (PV). GBO vary according to the state of arousal, are modulated by attention, and are correlated with conscious awareness. However, the subcortical cell types underlying the state-dependent control of GBO are not well understood. Here we tested the role of one cell type in the wakefulness-promoting basal forebrain (BF) region, cortically projecting GABAergic neurons containing PV, whose virally transduced fibers we found apposed cortical PV interneurons involved in generating GBO. Optogenetic stimulation of BF PV neurons in mice preferentially increased cortical GBO power by entraining a cortical oscillator with a resonant frequency of ∼40 Hz, as revealed by analysis of both rhythmic and nonrhythmic BF PV stimulation. Selective saporin lesions of BF cholinergic neurons did not alter the enhancement of cortical GBO power induced by BF PV stimulation. Importantly, bilateral optogenetic inhibition of BF PV neurons decreased the power of the 40-Hz auditory steady-state response, a read-out of the ability of the cortex to generate GBO used in clinical studies. Our results are surprising and novel in indicating that this presumptively inhibitory BF PV input controls cortical GBO, likely by synchronizing the activity of cortical PV interneurons. BF PV neurons may represent a previously unidentified therapeutic target to treat disorders involving abnormal GBO, such as schizophrenia.

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Section: Discussionmentioning

confidence: 69%

Section: Significancementioning

confidence: 99%

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

Kim

Thankachan

Mckenna

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

263

256

View full text Add to dashboard Cite

show abstract

“…State of arousal may have influenced our results since infants were studied while asleep and adults were studied awake. The effect of arousal is seen probably on the amplitude of the middle latency components evoked at or near threshold (Linden et al 1985) and not at suprathreshold (Picton et al 1974). Since the intensity used in the present study was suprathreshold (40 dB above detection of wave V of the ABR) this is not considered to be a significant influence on our results.…”

Section: Discussionmentioning

confidence: 69%

Binaural interaction of the auditory brain-stem potentials and middle latency auditory evoked potentials in infants and adults

McPherson

Tures

Starr

1989

Electroencephalography and Clinical Neurophysiology/Evoked Pote

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SummaryBinaural interactions in brain-stem auditory evoked potentials and in middle latency auditory evoked potentials were studied in 18 normal hearing adults and 10 normal term infants. Binaural interactions at the times of ABR waves V and VI were comparable in term infants and adults. Binaural interaction during the time domain of the middle latency auditory evoked potentials was the greatest at N2o in term infants and at N40 in adults. Measurement of binaural interaction during maturation may be a useful tool in assessing neurologically affected infants.

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“…Sleep and sedation have considerable effects on the physiological activity of the higher centers of the brain. Studies [Aoyagi et al, 1994a;Cohen et al, 1991;Dobie and Wilson, 1998;Galambos et al, 1981;Jerger et al, 1986;Linden et al, 1985;Plourde et al, 1991;Rees et al, 1986] have demonstrated that the 40-Hz ASSR response amplitude decreased during sleep and sedation. Plourde et al [1991] showed that 40-Hz ASSR response amplitudes were decreased to between one third to one half in sleeping humans, and a greater decrease was identified under conditions of general anesthesia.…”

Section: Origins Of the Auditory Steady-state Responsesmentioning

confidence: 99%

Electrically Evoked Auditory Steady-State Responses in Guinea Pigs

Jeng

Abbas²,

Brown³

et al. 2006

Audiol Neurotol

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Most cochlear implant systems available today provide the user with information about the envelope of the speech signal. The goal of this study was to explore the feasibility of recording electrically evoked auditory steady-state response (ESSR) and in particular to evaluate the degree to which the response recorded using electrical stimulation could be separated from stimulus artifact. Sinusoidally amplitude-modulated electrical stimuli with alternating polarities were used to elicit the response in adult guinea pigs. Separation of the stimulus artifact from evoked neural responses was achieved by summing alternating polarity responses or by using spectral analysis techniques. The recorded response exhibited physiological response properties including a pattern of nonlinear growth and their abolishment following euthanasia or administration of tetrodotoxin. These findings demonstrate that the ESSR is a response generated by the auditory system and can be separated from electrical stimulus artifact. As it is evoked by a stimulus that shares important features of cochlear implant stimulation, this evoked potential may be useful in either clinical or basic research efforts.

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Human Auditory Steady State Evoked Potentials during Sleep

Cited by 126 publications

References 2 publications

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

Binaural interaction of the auditory brain-stem potentials and middle latency auditory evoked potentials in infants and adults

Electrically Evoked Auditory Steady-State Responses in Guinea Pigs

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