Human Anticancers and Antidiabetic Activities of the Cyanobacterium Fischerella sp. BS1-EG Isolated from River Nile, Egypt

Ahmed, Bassant E.; Badawi, Mona H.; Mostafa, Salwa M.; Higazy, Aziz M.

doi:10.20546/ijcmas.2018.701.409

Cited by 24 publications

(15 citation statements)

References 15 publications

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“…The different compounds isolated from it have been explored and were found to be active against breast cancer (MCF-7), liver cancer (HepG-2), colon cancer (HCT116), and lung cancer (A549) cell lines. However, its crude extract BS1-EG exhibited various effects on all tested cell lines [ 99 ].…”

Section: Anticancer Potential Of Bioactive Compounds From Cyanobacmentioning

confidence: 99%

Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

et al. 2021

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Cyanobacteria (blue-green microalgae) are ubiquitous, Gram-negative photoautotrophic prokaryotes. They are considered as one of the most efficient sources of bioactive secondary metabolites. More than 50% of cyanobacteria are cultivated on commercial platforms to extract bioactive compounds, which have bene shown to possess anticancer activity. The chemically diverse natural compounds or their analogues induce cytotoxicity and potentially kill a variety of cancer cells via the induction of apoptosis, or altering the activation of cell signaling, involving especially the protein kinase-C family members, cell cycle arrest, mitochondrial dysfunctions and oxidative damage. These therapeutic properties enable their use in the pharma and healthcare sectors for the betterment of future generations. This review provides a baseline overview of the anti-cancerous cyanobacterial bioactive compounds, along with recently introduced nanomaterials that could be used for the development of new anticancer drugs to build a healthy future for mankind.

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Section: Anticancer Potential Of Bioactive Compounds From Cyanobacmentioning

confidence: 99%

Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

et al. 2021

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“…Some cyanobacterial such as Chroococcus minor, Synechocystis pavalakki, Phormidium corium, Arthrospira platensis, Oscillatoria chalybea, Spirulina labyrinthiformis, and Fischerella sp. show hypoglycaemic effects (Ahmed, Badawi, Mostafa, & Higazy, 2018;Senthilkumar & John, 2008). Arthrospira platensis, in particular, forms phytochemicals such as flavonoids, phytopigments, and sterols which have shown a strong hypoglycaemic effect, helping to reduce the blood glucose, Serum Glutamic Oxaloacetc Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), Acid phosphatase (ACP) and Alkaline phosphatase (ALP) levels in alloxan-induced diabetic rats, and suggesting that Spirulina has antihyperglycaemic activities (Senthilkumar & John, 2008).…”

Section: Cyanobacteria and Diabetesmentioning

confidence: 99%

Cyanotherapeutics: an emerging field for future drug discovery

Tiwari

2020

Applied Phycology

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Cyanobacteria are ubiquitously distributed oxygenic photosynthetic prokaryotes, present even in extreme environments. Many cyanobacteria have been found to be excellent sources of proteins and bioactive compounds. Their cosmopolitan availability, abundant important bioactive compounds and their associated health benefits make cyanobacteria an ideal target for therapeutic applications. Cyanobacteria have a potential role in nutraceutics and are also important in drug development. Several studies have advocated the use of cyanobacteria and their active principles in the treatment of various diseases because cyanobacteria display anti-cancer, antibacterial, antiimmunosuppressive, anti-tumour, neuroprotective, and antiviral activities. Thus, in this review, we have summarized and updated the therapeutic applications of cyanobacteria in drug development, with the introduction of the new term "cyanotherapeutics".

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“…действием. Скрининг цианобактерий на наличие антибиотиков открыл новые возможности в поиске новых лекарственных препаратов (Ahmed et al, 2018;Bajpai et al, 2018). Известно, что различные штаммы цианобактерий продуцируют внутриклеточные и внеклеточные метаболиты с анти-бактериальной активностью (Cragg, Newman, 2013).…”

Section: результатыunclassified

“…Экстракты цианобактерий, например штаммов Cyanothece sp. PCC7564 (El Semary, 2015) или Fischerella BS1-EG (Ahmed et al, 2018), выделенных в Египте, показали хорошую активность против рака молочной железы, легких и толстой кишки. Полисахарид из Nostoc commune Vauch.…”

Section: результатыunclassified

Biological activity of methanol extract from Nostoc sp. N42 and Fischerella sp. S29 isolated from aquatic and terrestrial ecosystems

Safavi¹,

Nowruzi²,

Estalaki³

et al. 2019

Algologia

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Human Anticancers and Antidiabetic Activities of the Cyanobacterium Fischerella sp. BS1-EG Isolated from River Nile, Egypt

Cited by 24 publications

References 15 publications

Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

Cyanotherapeutics: an emerging field for future drug discovery

Biological activity of methanol extract from Nostoc sp. N42 and Fischerella sp. S29 isolated from aquatic and terrestrial ecosystems

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