Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

Qamar, Hina; Hussain, Kashif; Soni, Aishwarya; Khan, Anish; Hussain, Touseef; Chénais, Benoı̂t

doi:10.3390/molecules26010247

Cited by 42 publications

(37 citation statements)

References 135 publications

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“…Among phytoplankton groups known to produce secondary bioactive metabolites, cyanobacteria are one of the most studied. Although these organisms are mainly known to produce toxins which may cause a variety of problems to human and environmental health (Chorus & Welker, 2021), some studies have shown that these secondary metabolites can be helpful to human health because of their immuno-enhancer and anticancer property (Jensen et al, 2001;Qamar et al, 2021). Moreover, the potential allochemical role of these substances has been proposed as a source of natural alternatives to synthetic pesticides (Berry et al, 2008).…”

Section: Provisioning Servicesmentioning

confidence: 99%

Ecosystem services provided by marine and freshwater phytoplankton

Naselli-Flores

Padisák

2022

Hydrobiologia

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Phytoplankton, the ecological group of microalgae adapted to live in apparent suspension in water masses, is much more than an ecosystem’s engineer. In this opinion paper, we use our experience as phytoplankton ecologists to list and highlight the services provided by phytoplankton, trying to demonstrate how their activity is fundamental to regulate and sustain Life on our Planet. Although the number of services produced by phytoplankton can be considered less numerous than that produced by other photosynthetic organisms, the ubiquity of this group of organisms, and their thriving across oceanic ecosystems make it one of the biological engines moving our biosphere. Supporting services provided by phytoplankton include almost half of the global primary and oxygen production. In addition, phytoplankton greatly pushes biogeochemical cycles and nutrient (re)cycling, not only in aquatic ecosystems but also in terrestrial ones. In addition, it significantly contributes to climate regulation (regulating services), supplies food, fuels, active ingredients and drugs, and genetic resources (provisioning services), has inspired artistic and craft works, mythology, and, of course, science (cultural services), and much more. Therefore, phytoplankton should be considered in all respects a true biosphere’s engineer.

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Section: Provisioning Servicesmentioning

confidence: 99%

Ecosystem services provided by marine and freshwater phytoplankton

Naselli-Flores

Padisák

2022

Hydrobiologia

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“…Numerous studies demonstrated antibacterial, antifungal, anti-tuberculosis, immune-depressing and anti-inflammatory properties of these bioactive compounds (Vijayakumar & Menakha, 2015;Rojas et al, 2020;Demay et al, 2021). Several species of cyanobacteria, cultivated on commercial platforms to obtain bioactive substances, are used in contemporary nanotechnological systems of selective transport of drugs to the tumours (Qamar et al, 2021).…”

Section: Marine Organisms Producing Cytotoxic Compoundsmentioning

confidence: 99%

Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)

Bocharova

Копытина

Slynko

2021

Regul. Mech. Biosyst.

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Oncological diseases for a long time have remained one of the most significant health problems of modern society, which causes great losses in its labour and vital potential. Contemporary oncology still faces unsolved issues as insufficient efficacy of treatment of progressing and metastatic cancer, chemoresistance, and side-effects of the traditional therapy which lead to disabilities among or death of a high number of patients. Development of new anti-tumour preparations with a broad range of pharmaceutical properties and low toxicity is becoming increasingly relevant every year. The objective of the study was to provide a review of the recent data about anti-tumour preparations of marine origin currently being at various phases of clinical trials in order to present the biological value of marine organisms – producers of cytotoxic compounds, and the perspectives of their use in modern biomedical technologies. Unlike the synthetic oncological preparations, natural compounds are safer, have broader range of cytotoxic activity, can inhibit the processes of tumour development and metastasis, and at the same time have effects on several etiopathogenic links of carcinogenesis. Currently, practical oncology uses 12 anti-tumour preparations of marine origin (Fludarabine, Cytarabine, Midostaurin, Nelarabine, Eribulin mesylate, Brentuximab vedotin, Trabectedin, Plitidepsin, Enfortumab vedotin, Polatuzumab vedotin, Belantamab mafodotin, Lurbinectedin), 27 substances are at different stages of clinical trials. Contemporary approaches to the treatment of oncological diseases are based on targeted methods such as immune and genetic therapies, antibody-drug conjugates, nanoparticles of biopolymers, and metals. All those methods employ bioactive compounds of marine origin. Numerous literature data from recent years indicate heightened attention to the marine pharmacology and the high potential of marine organisms for the biomedicinal and pharmaceutic industries.

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“…These natural products are often the result of an evolutionary process providing competitive advantages to their producers in their natural environments. Therefore, many of these natural products have notable biological activities, making them good candidates for drug development [ 3 , 4 , 5 ], including against infectious diseases such as malaria and tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments on the Synthesis and Bioactivity of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides That Demonstrate Anti-Malaria and Anti-Tuberculosis Activity

Kazmaier

Junk

2021

Marine Drugs

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Ilamycins/rufomycins and cyclomarins are marine cycloheptapeptides containing unusual amino acids. Produced by Streptomyces sp., these compounds show potent activity against a range of mycobacteria, including multidrug-resistant strains of Mycobacterium tuberculosis. The cyclomarins are also very potent inhibitors of Plasmodium falciparum. Biosynthetically the cyclopeptides are obtained via a heptamodular nonribosomal peptide synthetase (NRPS) that directly incorporates some of the nonproteinogenic amino acids. A wide range of derivatives can be obtained by fermentation, while bioengineering also allows the mutasynthesis of derivatives, especially cyclomarins. Other derivatives are accessible by semisynthesis or total syntheses, reported for both natural product classes. The anti-tuberculosis (anti-TB) activity results from the binding of the peptides to the N-terminal domain (NTD) of the bacterial protease-associated unfoldase ClpC1, causing cell death by the uncontrolled proteolytic activity of this enzyme. Diadenosine triphosphate hydrolase (PfAp3Aase) was found to be the active target of the cyclomarins in Plasmodia. SAR studies with natural and synthetic derivatives on ilamycins/rufomycins and cyclomarins indicate which parts of the molecules can be simplified or otherwise modified without losing activity for either target. This review examines all aspects of the research conducted in the syntheses of these interesting cyclopeptides.

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Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

Cited by 42 publications

References 135 publications

Ecosystem services provided by marine and freshwater phytoplankton

Ecosystem services provided by marine and freshwater phytoplankton

Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)

Recent Developments on the Synthesis and Bioactivity of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides That Demonstrate Anti-Malaria and Anti-Tuberculosis Activity

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