Human anelloviruses: an update of molecular, epidemiological and clinical aspects

Spandole, Sonia; Cimponeriu, Danut; Berca, Lavinia Mariana; Mihăescu, Grigore

doi:10.1007/s00705-015-2363-9

Cited by 225 publications

(297 citation statements)

References 186 publications

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confidence: 99%

“…[4][5][6] Reports on the prevalence in the general population vary greatly, most likely owing to the different thresholds of the PCR techniques used for the detection of the viral genome. 6 It is currently believed that 490% of the population is infected but that the viral load in blood may remain undetectable because genome replication is efficiently controlled by the immune system. The latter is clearly illustrated by the fact that the viral load increases greatly after immune suppression given to prevent rejection of transplanted organs 7,8 and that high copy numbers are present in the blood during secondary immune deficiencies in patients with AIDS 9 or after HSCT.…”

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confidence: 99%

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Torque teno virus in patients undergoing allogeneic hematopoietic stem cell transplantation for hematological malignancies

Masouridi‐Levrat

Pradier

Simonetta

et al. 2015

Bone Marrow Transplant

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confidence: 99%

mentioning

confidence: 99%

Torque teno virus in patients undergoing allogeneic hematopoietic stem cell transplantation for hematological malignancies

Masouridi‐Levrat

Pradier

Simonetta

et al. 2015

Bone Marrow Transplant

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“…Anellovirus infection is nearly universal, acquired early in life, often results in chronic viraemia, and frequently involves multiple species and genotypes (Bernardin et al, 2010). Although anellovirus infections are generally considered asymptomatic (Okamoto, 2009;Spandole et al, 2015), increased levels of anelloviruses have been associated with AIDS (Li et al, 2013;Thom & Petrik, 2007) and with immunosuppression in transplant patients (De Vlaminck et al, 2013;Young et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

The plasma virome of febrile adult Kenyans shows frequent parvovirus B19 infections and a novel arbovirus (Kadipiro virus)

Ngoi

Siqueira

et al. 2016

Journal of General Virology

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Viral nucleic acids present in the plasma of 498 Kenyan adults with unexplained fever were characterized by metagenomics analysis of 51 sample pools. The highest to lowest fraction of plasma pools was positive for parvovirus B19 (75 %), pegivirus C (GBV-C) (67 %), alpha anellovirus (59 %), gamma anellovirus (55 %), beta anellovirus (41 %), dengue virus genotype 2 (DENV-2) (16 %), human immunodeficiency virus type 1 (6 %), human herpesvirus 6 (6 %), HBV (4 %), rotavirus (4 %), hepatitis B virus (4 %), rhinovirus C (2 %), Merkel cell polyomavirus (MCPyV; 2 %) and Kadipiro virus (2 %). Ranking by overall percentage of viral reads yielded similar results. Characterization of viral nucleic acids in the plasma of a febrile East African population showed a high frequency of parvovirus B19 and DENV infections and detected a reovirus (Kadipiro virus) previously reported only in Asian Culex mosquitoes, providing a baseline to compare with future virome studies to detect emerging viruses in this region.

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“…The prevalence of TTV infection has been also reported to be high among patients with liver diseases, including hepatocellular carcinoma (39%), non-A to -G liver disease (46%), non-A to -G fulminant hepatitis (47%), and cirrhosis (48%) (8). In addition, the prevalence of TTV DNA in blood donors and thalassemia patients has been estimated at 20% and 57.2% in Iran, respectively (9).…”

Section: Introductionmentioning

confidence: 99%

“…Although this infection is possibly associated with some diseases, such as hepatitis, cancer, respiratory diseases, hematological disorders, and HIV infection, there are controversies about the disease-causing potential of TTV in human populations due to its ubiquity. In fact, only certain TTV genotypes and species may be particularly pathogenic un-der certain conditions (8). Since the beginning of HIV/AIDS epidemics, approximately 60 million people have been reported to have HIV, and nearly 25 million people have died, thereby indicating the importance of this epidemic (10,11).…”

Section: Introductionmentioning

confidence: 99%

Higher Frequency of Transfusion-Transmitted Virus (TTV) in HIV Patients in Comparison with Healthy Blood Donors

Taheri

Motamedifar

Sarvari

et al. 2017

Int J High Risk Behav Addict

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Background: Epidemiological studies have reported commonly distributed transfusion-transmitted virus (TTV) in different populations with parental risk factors, including human immunodeficiency virus (HIV). Objectives: This study was performed to determine and compare the prevalence of TTV infection among HIV-positive patients and healthy blood donors. Patients and Methods: A total of 186 HIV patients and 165 healthy blood donors with no markers of HIV infection were included in this study during 2004 -2012. Semi-nested Polymerase Chain Reaction (PCR) assay was performed for the detection of TTV DNA. HBV surface antigen (HBsAg), Hepatitis C Virus Antibody (HCVAb), and CD4 were investigated in the sera of HIV-positive subjects. Aspartate transaminase (AST) and Alanine transaminase (ALT) levels were also measured. Results: The mean age of HIV-positive and healthy subjects was 39.3 and 40.5 years, respectively. In total, 182 (97.9%) subjects were male and 4 (2.1%) were female. TTV DNA was detected in 35 out of 186 HIV patients (18.8%; 95% CI, 13.2 -24.4%). The prevalence of TTV in the HIV group was significantly higher (P = 0.027) than blood donors (11%; 95% CI, 6.2 -15.8%). Age, marital status, unsafe sexual activity, and use of injection drugs were not significantly associated with the prevalence of TTV infection in HIV patients. Conclusions: Considering the higher frequency of TTV infection in HIV patients in comparison to healthy blood donors, HIV infection may be an important risk factor for TTV infection. In addition, the lower frequency of TTV infection in healthy individuals in comparison to HIV patients reveals the transmission of TTV infection via routes other than blood and drug injection; therefore, the effect of fecal-oral route needs to be examined in future studies.

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Human anelloviruses: an update of molecular, epidemiological and clinical aspects

Cited by 225 publications

References 186 publications

Torque teno virus in patients undergoing allogeneic hematopoietic stem cell transplantation for hematological malignancies

Torque teno virus in patients undergoing allogeneic hematopoietic stem cell transplantation for hematological malignancies

The plasma virome of febrile adult Kenyans shows frequent parvovirus B19 infections and a novel arbovirus (Kadipiro virus)

Higher Frequency of Transfusion-Transmitted Virus (TTV) in HIV Patients in Comparison with Healthy Blood Donors

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