Human amygdala responses during presentation of happy and neutral faces: correlations with state anxiety

Somerville, Leah H.; Kim, Hackjin; Johnstone, Tom; Alexander, Andrew L.; Whalen, Paul J.

doi:10.1016/j.biopsych.2004.01.007

Cited by 233 publications

(167 citation statements)

References 45 publications

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…The amygdala is perhaps the most extensively studied subcortical structure that is involved in emotion processing, particularly with respect to its role in the perception and response to danger 79,80 . Contrary to the traditional view, positively valenced emotional stimuli, like happy or surprised expressions, can also activate the amygdala 49,81,82 but with a qualitatively different response profile that entails more activity in ventral parts and only at later stimulus presentations compared to fearful expressions 82 . Amygdala activation in response to emotional stimuli has been reported under conditions of sensory 6,7,46,[48][49][50][51][52][53][54][55][56] and attentional unawareness 25-28 in neurologically intact observers and in brain-damaged patients with cortical blindness or hemispatial neglect.…”

Section: Comparing Attentional and Sensory Unawarenessmentioning

confidence: 88%

Neural bases of the non-conscious perception of emotional signals

2010

View full text Add to dashboard Cite

| Many emotional stimuli are processed without being consciously perceived. Recent evidence indicates that subcortical structures have a substantial role in this processing. These structures are part of a phylogenetically ancient pathway that has specific functional properties and that interacts with cortical processes. There is now increasing evidence that non-consciously perceived emotional stimuli induce distinct neurophysiological changes and influence behaviour towards the consciously perceived world. Understanding the neural bases of the non-conscious perception of emotional signals will clarify the phylogenetic continuity of emotion systems across species and the integration of cortical and subcortical activity in the human brain.

show abstract

Section: Comparing Attentional and Sensory Unawarenessmentioning

confidence: 88%

Neural bases of the non-conscious perception of emotional signals

2010

View full text Add to dashboard Cite

show abstract

“…Healthy controls, both at rest and in response to a serotonergic probe, show positive correlations between OFC (BA 11,12) and right ventral amygdala, as was predicted from the model of the ventral amygdala as the component of human amygdala most closely associated with frontal lobe emotion modulation (Kim et al, 2003;Somerville et al, 2004;Whalen et al, 1998). This correlational approach is based on the assumption that significant correlations may reveal an important functional relationship between the structures as discussed by Katz et al (1996).…”

Section: Implications Of Group Differences In Fronto-amygdala Correlamentioning

confidence: 88%

Amygdala–Prefrontal Disconnection in Borderline Personality Disorder

New

Hazlett

Buchsbaum

et al. 2007

Neuropsychopharmacol

258

160

View full text Add to dashboard Cite

Abnormal fronto-amygdala circuitry has been implicated in impulsive aggression, a core symptom of borderline personality disorder (BPD). We examined relative glucose metabolic rate (rGMR) at rest and after m-CPP (meta-chloropiperazine) with 18 fluorodeoxyglucose (FDG) with positron emission tomography (PET) in 26 impulsive aggressive (IED)-BPD patients and 24 controls. Brain edges/amygdala were visually traced on MRI scans co-registered to PET scans; rGMR was obtained for ventral and dorsal regions of the amygdala and Brodmann areas within the prefrontal cortex (PFC). Correlation coefficients were calculated between rGMR for dorsal/ventral amygdala regions and PFC. Additionally, amygdala volumes and rGMR were examined in BPD and controls. Correlations PFC/amygdala Placebo: Controls showed significant positive correlations between right orbitofrontal (OFC) and ventral, but not dorsal, amygdala. Patients showed only weak correlations between amygdala and the anterior PFC, with no distinction between dorsal and ventral amygdala. Correlations PFC/amygdala: m-CPP response: Controls showed positive correlations between OFC and amygdala regions, whereas patients showed positive correlations between dorsolateral PFC and amygdala. Group differences between interregional correlational matrices were highly significant. Amygdala volume/metabolism: No group differences were found for amygdala volume, or metabolism in the placebo condition or in response to meta-chloropiperazine (m-CPP). We demonstrated a tight coupling of metabolic activity between right OFC and ventral amygdala in healthy subjects with dorsoventral differences in amygdala circuitry, not present in IED-BPD. We demonstrated no significant differences in amygdala volumes or metabolism between BPD patients and controls.

show abstract

“…Notably, MAP reactivity varied with activation in the dorsal portion of the amygdala, extending into the sublenticular area. In humans, the dorsal amygdala encompasses the central nucleus and is thought to support coordinated visceromotor and behavioral arousal processes (Kapp et al, 1992;Whalen, 1998;Somerville et al, 2004).…”

Section: Map Reactivity and Amygdala Activationmentioning

confidence: 99%

“…Note that in supplemental Figure 3A (available at www.jneurosci.org as supplemental material), the amygdala foci where MAP reactivity varied with gray matter volume overlapped with, but were generally more ventral to, the dorsal foci where MAP reactivity varied with BOLD activation. In humans, the ventral amygdala encompasses the basolateral complex, which is thought to support the convergent pro- cessing of behaviorally salient stimuli (Kapp et al, 1992;Whalen, 1998;Somerville et al, 2004). These anatomical comparisons, however, should be cautiously viewed in light of the different spatial resolutions of the BOLD and VBM data.…”

Section: Map Reactivity and Gray Matter Volumementioning

confidence: 99%

Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala

Gianaros¹,

Sheu²,

Matthews³

et al. 2008

J. Neurosci.

245

222

View full text Add to dashboard Cite

Individuals who exhibit exaggerated blood pressure reactions to psychological stressors are at risk for hypertension, ventricular hypertrophy, and premature atherosclerosis; however, the neural systems mediating exaggerated blood pressure reactivity and associated cardiovascular risk in humans remain poorly defined. Animal models indicate that the amygdala orchestrates stressor-evoked blood pressure reactions via reciprocal signaling with corticolimbic and brainstem cardiovascular-regulatory circuits. Based on these models, we used a multimodal neuroimaging approach to determine whether human individual differences in stressor-evoked blood pressure reactivity vary with amygdala activation, gray matter volume, and functional connectivity with corticolimbic and brainstem areas implicated in stressor processing and cardiovascular regulation. We monitored mean arterial pressure (MAP) and concurrent functional magnetic resonance imaging BOLD signal changes in healthy young individuals while they completed a Stroop color-word stressor task, validated previously in epidemiological studies of cardiovascular risk. Individuals exhibiting greater stressor-evoked MAP reactivity showed (1) greater amygdala activation, (2) lower amygdala gray matter volume, and (3) stronger positive functional connectivity between the amygdala and perigenual anterior cingulate cortex and brainstem pons. Individual differences in amygdala activation, gray matter volume, and functional connectivity with corticolimbic and brainstem circuits may partly underpin cardiovascular disease risk by impacting stressor-evoked blood pressure reactivity.

show abstract

Human amygdala responses during presentation of happy and neutral faces: correlations with state anxiety

Cited by 233 publications

References 45 publications

Neural bases of the non-conscious perception of emotional signals

Neural bases of the non-conscious perception of emotional signals

Amygdala–Prefrontal Disconnection in Borderline Personality Disorder

Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala

Contact Info

Product

Resources

About