Human amniotic membrane for the treatment of large and refractory macular holes: a retrospective, multicentric, interventional study

Ferreira, Magno Antônio; Maia, André; Machado, André Jucá; Ferreira, Raquel Eustaquio Alves; Hagemann, Luiz Felipe; Júnior, Pedro Hélio Estevam Ribeiro; Rezende, Flávio

doi:10.1186/s40942-021-00308-6

Cited by 17 publications

(18 citation statements)

References 31 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean minimum MH diameter was 779.8 ± 142.53 lm in the SF6 group and 799 ± 175.18 lm in the air group. Similar success rates have been reported in additional case series with the use of hAM for MH closure, though studies comparing this technique to others have not been published [74][75][76].…”

Section: Autologous Retinal Transplantsupporting

confidence: 68%

Surgical Management of Recurrent and Persistent Macular Holes: A Practical Approach

Cao

Kaiser

2021

Ophthalmol Ther

View full text Add to dashboard Cite

Primary surgery for macular hole (MH) closure has a high success rate with current methods of pars plana vitrectomy and internal limiting membrane (ILM) peeling. When primary surgery fails, there are several options available for secondary repair, including extension of the ILM peel, creation of an ILM flap, pedunculated ILM flap, lens capsule flap transplantation, autologous retinal transplantation, use of a human amniotic membrane plug, adjuvant autologous platelet concentrate, induction of macular detachments with subretinal blebs, and creation of retinal incisions. In this review, we discuss the practical approach to each of these surgical techniques for the management of recurrent or persistent MHs.

show abstract

Section: Autologous Retinal Transplantsupporting

confidence: 68%

Surgical Management of Recurrent and Persistent Macular Holes: A Practical Approach

Cao

Kaiser

2021

Ophthalmol Ther

View full text Add to dashboard Cite

show abstract

“…Members of the CLOSE study group participated in thirteen of these studies, representing 1044 eyes (82.5%) from the 1265 eyes included in the analysis. [ 7 , 12 – 16 , 23 – 25 , 31 , 39 – 41 ].…”

Section: Resultsmentioning

confidence: 99%

Surgical classification for large macular hole: based on different surgical techniques results: the CLOSE study group

et al. 2023

View full text Add to dashboard Cite

Background The CLOSE study group proposes an updated surgical classification for large macular holes based on a systematic review of new treatments. Recently, many new techniques have been introduced to treat large full-thickness macular holes (FTMH); although the indications are not clear. An updated surgical classification is needed to help surgical decision-making. Methods We gathered published series by the CLOSE Study Group members and from literature search until June 2021. Techniques included: internal limiting membrane peeling (ILM peeling), ILM flaps, macular hydrodissection (macular hydro), human amniotic membrane graft (hAM), and autologous retinal transplantation (ART). Within each technique, chi-square test assessed association between the minimal linear diameter (MLD) (in µm) and closure rate; the postoperative best-corrected visual acuity (BCVA) gains were compared among groups. Results Data extraction included 31 published articles: total of 1135 eyes. Eyes were divided into the following groups: ILM peel (n: 683), ILM Flap (n: 233), macular hydrodissection (n: 64), hAM (n: 59), and ART (n: 96). The initial BCVA and size were heterogenous between the groups. ILM peel showed the best results in large FTMH ≤ 535 µm (closure rate 96.8%); adjusted mean BCVA: 0.49 (LogMAR) with a statistical difference among groups. Large FTMH between 535 and 799 µm: ILM flap technique showed better results (closure rate 99.0%); adjusted mean BCVA: 0.67(LogMAR); also with a statistical difference. For large FTMH ≥ 800 µm more invasive techniques are required. Use of hAM, macular hydrodissection and ART showed higher closure rates for this category (100%, 83.3% and 90.5% respectively), and adjusted mean BCVA varied from 0.76 to 0.89. Although there was no statistical difference between those techniques for this group due to the smaller number of cases. Conclusions The CLOSE study group demonstrated the potential usefulness of a new surgical classification for large FTMHs and propose OCT biomarkers for use in clinical practice and future research. This new classification demonstrated that Large (400–550 µm) and X-Large (550–800 µm) holes can be treated highly successfully with ILM peel and ILM flap techniques, respectively. Further studies are necessary for the larger FTMHs (XX-Large and Giant), using the CLOSE classification, in order to determine which technique is better suited for each hole size and characteristics.

show abstract

“…Ferreira MA [ 11 ] performed a retrospective chart review that was carried out in five different centers to identify all cases that underwent off-label human amniotic membrane graft for the treatment of large or failed macular holes (MH). 19 eyes of 19 patients were identified and included in the study.…”

Section: Discussionmentioning

confidence: 99%

A study of post-operative clinico-imaging status and visual outcome after idiopathic macular hole surgery with amniotic membrane plug

Srivastava

Singh

et al. 2022

rjo

View full text Add to dashboard Cite

show abstract

Human amniotic membrane for the treatment of large and refractory macular holes: a retrospective, multicentric, interventional study

Cited by 17 publications

References 31 publications

Surgical Management of Recurrent and Persistent Macular Holes: A Practical Approach

Surgical Management of Recurrent and Persistent Macular Holes: A Practical Approach

Surgical classification for large macular hole: based on different surgical techniques results: the CLOSE study group

A study of post-operative clinico-imaging status and visual outcome after idiopathic macular hole surgery with amniotic membrane plug

Contact Info

Product

Resources

About