Human adipose-derived stromal cells for the production of completely autologous self-assembled tissue-engineered vascular substitutes

Vallières, Karine; Laterreur, Véronique; Tondreau, Maxime Y.; Ruel, Jean; Germain, Lucie; Fradette, Julie; Auger, François A.

doi:10.1016/j.actbio.2015.06.011

Cited by 30 publications

(24 citation statements)

References 45 publications

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“…More recently, a novel autologous small‐diameter TEVG was fabricated via the self‐assembly of autologous AD‐MSCs. This TEVG displayed satisfied mechanical properties and appropriate endothelium …”

Section: Multipotent Stem Cellsmentioning

confidence: 81%

Cell‐based strategies for vascular regeneration

Zou

Fan

Fartash

et al. 2016

J Biomedical Materials Res

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Vascular regeneration is known to play an essential role in the repair of injured tissues mainly through accelerating the repair of vascular injury caused by vascular diseases, as well as the recovery of ischemic tissues. However, the clinical vascular regeneration is still challenging. Cell-based therapy is thought to be a promising strategy for vascular regeneration, since various cells have been identified to exert important influences on the process of vascular regeneration such as the enhanced endothelium formation on the surface of vascular grafts, and the induction of vessel-like network formation in the ischemic tissues. Here are a vast number of diverse cell-based strategies that have been extensively studied in vascular regeneration. These strategies can be further classified into three main categories, including cell transplantation, construction of tissue-engineered grafts, and surface modification of scaffolds. Cells used in these strategies mainly refer to terminally differentiated vascular cells, pluripotent stem cells, multipotent stem cells, and unipotent stem cells. The aim of this review is to summarize the reported research advances on the application of various cells for vascular regeneration, yielding insights into future clinical treatment for injured tissue/organ.

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Section: Multipotent Stem Cellsmentioning

confidence: 81%

Cell‐based strategies for vascular regeneration

Zou

Fan

Fartash

et al. 2016

J Biomedical Materials Res

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“…To assess the relation between vessel expansion and applied internal pressure, compliance was determined. The compliance was calculated using the following equation and reported as percentage per 100 mmHg as specified in the ANSI 7198 standard as described previously …”

Section: Methodsmentioning

confidence: 99%

Determining the optimal protocol for preparing an acellular scaffold of tissue engineered small‐diameter blood vessels

Pan

et al. 2017

J Biomed Mater Res

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Although detergent-based decellularization protocols have been widely used to obtain a natural extracellular matrix (ECM) scaffold in tissue engineering, some key challenges still exist. To achieve an optimum natural decellularized scaffold for the construction of tissue-engineered small-diameter blood vessels (TEBV), porcine carotid arteries (PCAs) were decellularized by combining sodium dodecyl sulfate (SDS), sodium deoxycholate (SDC) and Triton X-100 (Triton) in different concentrations. Tissue samples were processed and their histological, biochemical and biomechanical characteristics were investigated. Results showed that only two methods 0.5% (SDS + SDC) and 1% (SDS + SDC) could completely remove of the cellular contents and preserve the native ECM architecture. Furthermore, 1% (SDS + SDC) based methods acquire preferable porosity and suitable mechanical strength. Residual Triton in the ECM scaffold holds intensive cytotoxity. In conclusion, 1%(SDS + SDC) based method can obtain a superior PCAs scaffold for the construction of TEBV. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 619-631, 2018.

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“…Although minimally invasive treatments such as balloon angioplasty and stenting can be used in some cases, the most widely used therapeutic procedure for high-risk patients remains the coronary artery bypass graft 2 . Clinically, the current “gold standard” is autologous grafting, where the saphenous vein and an internal mammary artery with excellent long-term patency are utilized to bypass the diseased vessel 3, 4 . However, the use of autologous grafts is associated with problems such as accelerated atherosclerotic changes (limited to veins), donor site morbidity and the need for additional harvest.…”

Section: Introductionmentioning

confidence: 99%

A Biomimetic Heparinized Composite Silk-Based Vascular Scaffold with sustained Antithrombogenicity

Zamani

Khafaji

Naji

et al. 2017

Sci Rep

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Autologous grafts, as the gold standard for vascular bypass procedures, associated with several problems that limit their usability, so tissue engineered vessels have been the subject of an increasing number of works. Nevertheless, gathering all of the desired characteristics of vascular scaffolds in the same construct has been a big challenge for scientists. Herein, a composite silk-based vascular scaffold (CSVS) was proposed to consider all the mechanical, structural and biological requirements of a small-diameter vascular scaffold. The scaffold’s lumen composed of braided silk fiber-reinforced silk fibroin (SF) sponge covalently heparinized (H-CSVS) using Hydroxy-Iron Complexes (HICs) as linkers. The highly porous SF external layer with pores above 60 μm was obtained by lyophilization. Silk fibers were fully embedded in scaffold’s wall with no delamination. The H-CSVS exhibited much higher burst pressure and suture retention strength than native vessels while comparable elastic modulus and compliance. H-CSVSs presented milder hemolysis in vitro and significant calcification resistance in subcutaneous implantation compared to non-heparinized ones. The in vitro antithrombogenic activity was sustained for over 12 weeks. The cytocompatibility was approved using endothelial cells (ECs) and vascular smooth muscle cells (SMCs) in vitro. Therefore, H-CSVS demonstrates a promising candidate for engineering of small-diameter vessels.

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Human adipose-derived stromal cells for the production of completely autologous self-assembled tissue-engineered vascular substitutes

Cited by 30 publications

References 45 publications

Cell‐based strategies for vascular regeneration

Cell‐based strategies for vascular regeneration

Determining the optimal protocol for preparing an acellular scaffold of tissue engineered small‐diameter blood vessels

A Biomimetic Heparinized Composite Silk-Based Vascular Scaffold with sustained Antithrombogenicity

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