Human Adipose-Derived Stem Cells (ASC): Their Efficacy in Clinical Applications

Locke, Marius; Feisst, Vaughan

doi:10.1007/978-1-4471-6542-2_13

Cited by 3 publications

(1 citation statement)

References 125 publications

(83 reference statements)

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“…Adipose tissue‐derived stem cells (ATSCs) have recently been widely studied as a viable cell source for cell‐based regenerative medicine (Locke and Feisst, ). These cells have shown to have properties similar to BMSSCs.…”

Section: Non Dental‐derived Post‐natal Stem Cellsmentioning

confidence: 99%

Potential for Stem Cell‐Based Periodontal Therapy

Bassir

Wisitrasameewong

Raanan

et al. 2015

Journal Cellular Physiology

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Periodontal diseases are highly prevalent and are linked to several systemic diseases. The goal of periodontal treatment is to halt the progression of the disease and regenerate the damaged tissue. However, achieving complete and functional periodontal regeneration is challenging because the periodontium is a complex apparatus composed of different tissues, including bone, cementum, and periodontal ligament. Stem cell-based regenerative therapy may represent an effective therapeutic tool for periodontal regeneration due to their plasticity and ability to differentiate into different cell lineages. This review presents and critically analyzes the available information on stem cell-based therapy for the regeneration of periodontal tissues and suggests new avenues for the development of more effective therapeutic protocols.

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Section: Non Dental‐derived Post‐natal Stem Cellsmentioning

confidence: 99%

Potential for Stem Cell‐Based Periodontal Therapy

Bassir

Wisitrasameewong

Raanan

et al. 2015

Journal Cellular Physiology

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Tissue Engineering in Periodontal Regeneration

Iranparvar

Nozariasbmarz

DeGrave

et al. 2019

Applications of Biomedical Engineering in Dentistry

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Spider silk enhanced tissue engineering of cartilage tissue: Approach of a novel bioreactor model using adipose derived stromal cells

Strauß,

Diemer,

Bucan

et al. 2024

Journal of Applied Biomaterials & Functional Materials

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Human cartilage tissue remains a challenge for the development of therapeutic options due to its poor vascularization and reduced regenerative capacities. There are a variety of research approaches dealing with cartilage tissue engineering. In addition to different biomaterials, numerous cell populations have been investigated in bioreactor-supported experimental setups to improve cartilage tissue engineering. The concept of the present study was to investigate spider silk cocoons as scaffold seeded with adipose-derived stromal cells (ASC) in a custom-made bioreactor model using cyclic axial compression to engineer cartilage-like tissue. For chemical induction of differentiation, BMP-7 and TGF-β2 were added and changes in cell morphology and de-novo tissue formation were investigated using histological staining to verify chondrogenic differentiation. By seeding spider silk cocoons with ASC, a high colonization density and cell proliferation could be achieved. Mechanical induction of differentiation using a newly established bioreactor model led to a more roundish cell phenotype and new extracellular matrix formation, indicating a chondrogenic differentiation. The addition of BMP-7 and TGF-β2 enhanced the expression of cartilage specific markers in immunohistochemical staining. Overall, the present study can be seen as pilot study and valuable complementation to the published literature.

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Human Adipose-Derived Stem Cells (ASC): Their Efficacy in Clinical Applications

Cited by 3 publications

References 125 publications

Potential for Stem Cell‐Based Periodontal Therapy

Potential for Stem Cell‐Based Periodontal Therapy

Tissue Engineering in Periodontal Regeneration

Spider silk enhanced tissue engineering of cartilage tissue: Approach of a novel bioreactor model using adipose derived stromal cells

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