Human Adenovirus Surveillance — United States, 2003–2016

Binder, Alison M.; Biggs, Holly M.; Haynes, Amber; Chommanard, Christina; Lu, Xiaoyan; Erdman, Dean D.; Watson, John T.; Gerber, Susan I.

doi:10.15585/mmwr.mm6639a2

Cited by 110 publications

(118 citation statements)

References 10 publications

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“…The virus antibody titers against these adenoviruses seem to reflect an epidemic in Japan. Similar numbers of HAdVs 1, 2, 3, 7, and 11 were detected in the United States and in Japan …”

Section: Discussionsupporting

confidence: 58%

Long‐term monitoring of virus antibody titers in human intravenous immunoglobulin lots derived from donors in Japan

Onodera¹,

Nakagawa²,

Nakagawa

et al. 2018

Transfusion

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BACKGROUND Intravenous immunoglobulin (IVIG) contains immunoglobulin G against various viruses, except those that have been screened, such as human immunodeficiency and hepatitis C viruses. Antivirus titers reflect the serostatus of the blood donor population in the collection region and are of clinical interest. STUDY DESIGN AND METHODS During the past 10 years, measles, mumps, rubella, varicella‐zoster, hepatitis A and B, Epstein‐Barr, and human respiratory syncytial viruses; human parainfluenza viruses 1, 2, and 3; human herpes simplex viruses 1 and 2; human herpesvirus 6; cytomegalovirus (CMV); human adenoviruses (HAdVs) 1, 2, 3, 7, and 11; human parvovirus B19; and human echovirus 9 and 11 titers in IVIG lots have been measured by a commercial testing facility. A viral neutralizing assay for CMV has been used at our facility. Herein, we summarize the measurements and results of a regression analysis of the trends in virus antibody titers. RESULTS IVIG lots contained significant titers against all of the above viruses, except for HAdV 7. Three patterns—stable, increasing, and decreasing—were observed, without any drastic changes. Although these trends reflect the seroprevalence in Japan, the titers were not obviously affected by the cycle of epidemics. On the other hand, the prevalence data suggest that titers against hepatitis A virus and other viruses will decrease in the near future, although they are currently stable. CONCLUSION Monitoring the titer of IVIG lots and seroprevalence of donor populations is important for anticipating future changes in virus antibody titers of IVIG lots and can provide useful information of clinical interest.

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“…The virus antibody titers against these adenoviruses seem to reflect an epidemic in Japan. Similar numbers of HAdVs 1, 2, 3, 7, and 11 were detected in the United States and in Japan …”

Section: Discussionsupporting

confidence: 58%

Long‐term monitoring of virus antibody titers in human intravenous immunoglobulin lots derived from donors in Japan

Onodera¹,

Nakagawa²,

Nakagawa

et al. 2018

Transfusion

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“…In immunocompromised patients, HAdV infection can cause a variety of clinical syndromes ranging from asymptomatic viraemia, through localised acute respiratory illness, gastroenteritis, conjunctivitis, or urinary tract infection, to disseminated disease. In this population of patients, HAdV infections can be very severe, and can cause respiratory failure, haemorrhagic cystitis, neurologic disease, and disseminated infection with lethal failure of individual or multiple organs …”

Section: Introductionmentioning

confidence: 99%

Management of adenovirus infection in patients after haematopoietic stem cell transplantation: State‐of‐the‐art and real‐life current approach

Hiwarkar

Kosulin²,

Cesaro

et al. 2018

Reviews in Medical Virology

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The important insights gained over the past years in diagnosis and treatment of invasive adenoviral infections provide new paradigms for the monitoring and clinical management of these life-threatening complications. A meeting was held to discuss and subsequently disseminate the current advances in our understanding of the aetiology/pathogenesis and future treatment options facilitating effective control or prevention of adenovirus-related diseases in the allogeneic haematopoietic stem cell transplant setting. Invited experts in the field discussed recent progress with leading members of the Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation at the "State-of-the-art" Meeting in Poznan, Poland, in October 2017. In this review article, the panel of experts presents a concise summary of the current evidence based on published data from the last 15 years and on recent achievements resulting from real-life practice. The present position statement reflects an expert opinion on current approaches to clinical management of adenovirus infections in patients undergoing allogeneic haematopoietic stem cell transplant and provides graded recommendations of the panel for diagnostic approaches and preemptive therapy reflecting the present state of knowledge.

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“…The following viruses were identified as concerns for PIDs by major stakeholders, and knowledge about antibody titers against these in Ig preparations are therefore of potential clinical utility: cytomegalovirus (CMV), HAdV, varicella zoster virus (VZV), Epstein‐Barr virus (EBV), enteroviruses (coxsackie virus and echovirus), RSV, hPIV, herpes simplex virus (HSV), rota virus, WNV, HAV, hepatitis B and C viruses (HBV and HCV, respectively), rhino virus, and influenza virus …”

Section: Resultsmentioning

confidence: 99%

Immunoglobulins and virus antibody titers: of past needs, current requirements, and future options

Kreil

Farcet

2018

Transfusion

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BACKGROUND Immunoglobulins (Igs) have been in clinical use for almost 70 years, and early on were also used in conjunction with exposure to the measles virus or polio virus. The US regulations that describe functional Ig lot release thus require the demonstration of minimum antibody titers against these two viruses, although the use of vaccines has now dramatically reduced their incidence. The lower clinical importance of these viruses raises the question of whether other virus antibodies might be more informative for patients with immunodeficiency. STUDY DESIGN AND METHODS A literature survey was conducted to identify viruses of potential clinical concern for people with immunodeficiency. The viruses selected have stable seroepidemiology and associated functional antibody assays. As a result, neutralizing antibody titers to human adenovirus 5 (HAdV5), respiratory syncytial virus (RSV) serotypes A and B, and human parainfluenza virus 3 (hPIV3) were determined in Ig lots produced from plasma collected in either the United States or the European Union. RESULTS The virus antibody titers measured were high and consistent among the Ig lots tested. Use of either US‐ or EU‐derived plasma as starting material resulted in equivalent virus antibody titers, with the exception of RSV serotype B, for which a lower titer was seen in EU plasma–derived Ig lots. CONCLUSION With the significant decline in measles virus and polio virus circulation, and even their potential eradication, measurement of antibody titers against other viruses in Ig products may be more informative for functional lot release testing.

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Human Adenovirus Surveillance — United States, 2003–2016

Cited by 110 publications

References 10 publications

Long‐term monitoring of virus antibody titers in human intravenous immunoglobulin lots derived from donors in Japan

Long‐term monitoring of virus antibody titers in human intravenous immunoglobulin lots derived from donors in Japan

Management of adenovirus infection in patients after haematopoietic stem cell transplantation: State‐of‐the‐art and real‐life current approach

Immunoglobulins and virus antibody titers: of past needs, current requirements, and future options

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