Long‐term monitoring of virus antibody titers in human intravenous immunoglobulin lots derived from donors in Japan

Abstract

BACKGROUND Intravenous immunoglobulin (IVIG) contains immunoglobulin G against various viruses, except those that have been screened, such as human immunodeficiency and hepatitis C viruses. Antivirus titers reflect the serostatus of the blood donor population in the collection region and are of clinical interest. STUDY DESIGN AND METHODS During the past 10 years, measles, mumps, rubella, varicella‐zoster, hepatitis A and B, Epstein‐Barr, and human respiratory syncytial viruses; human parainfluenza viruses 1, 2, and 3; human herpes simplex viruses 1 and 2; human herpesvirus 6; cytomegalovirus (CMV); human adenoviruses (HAdVs) 1, 2, 3, 7, and 11; human parvovirus B19; and human echovirus 9 and 11 titers in IVIG lots have been measured by a commercial testing facility. A viral neutralizing assay for CMV has been used at our facility. Herein, we summarize the measurements and results of a regression analysis of the trends in virus antibody titers. RESULTS IVIG lots contained significant titers against all of the above viruses, except for HAdV 7. Three patterns—stable, increasing, and decreasing—were observed, without any drastic changes. Although these trends reflect the seroprevalence in Japan, the titers were not obviously affected by the cycle of epidemics. On the other hand, the prevalence data suggest that titers against hepatitis A virus and other viruses will decrease in the near future, although they are currently stable. CONCLUSION Monitoring the titer of IVIG lots and seroprevalence of donor populations is important for anticipating future changes in virus antibody titers of IVIG lots and can provide useful information of clinical interest.

Long‐term monitoring of antibody titers against microorganisms in human intravenous immunoglobulin lots derived from healthy donors in Japan manufactured during 1998–2018

“…There are only a few reports on the trends in antibody titers of IVIG against pathogens such as bacteria, although the monitoring of antibody titers is important for predicting their future status. We previously reported titers and trends against viruses over the past 10 years, the trends of titers against the viruses were stable or decreasing, whereas only a few cases of increasing titers were observed 7 . In this study, we evaluated titers of 606 VGIH lots against microorganisms except viruses causing respiratory and opportunistic infections in patients such as those with PID/SID, including their long‐term trends over a 10‐year period, using the same concept as that followed in a previous study.…”

“…We previously reported titers and trends against viruses over the past 10 years, the trends of titers against the viruses were stable or decreasing, whereas only a few cases of increasing titers were observed. 7 In this study, we evaluated titers of 606 VGIH lots against microorganisms except viruses causing respiratory and opportunistic infections in patients such as those with PID/SID, including their long-term trends over a 10-year period, using the same concept as that followed in a previous study. Interestingly, the titers were mostly stable or slightly decreasing, similar to the trends of viruses.…”

“…Long-term trends in titers of IVIG lots against viruses have been evaluated previously. 7 However, the long-term trends of the IVIG lots against the bacteria and fungi have not been evaluated. In this study, we measured the titers of IVIG lots against representative microorganisms, namely Staphylococcus, Streptococcus, Enterococcus, Pseudomonas, Klebsiella, Haemophilus, Bordetella, Serratia, and Candida, for a long time.…”

“…Long‐term trends in titers of IVIG lots against viruses have been evaluated previously 7 . However, the long‐term trends of the IVIG lots against the bacteria and fungi have not been evaluated.…”