Hubungan Kadar Feritin Serum dengan Fungsi Kognitif Berdasarkan Pemeriksaan Status Mini-Mental (MMSE) pada Penyandang Thalassemia Anak

Ma’ani, Fathiyah; Fadlyana, Eddy; Rahayuningsih, Sri Endah

doi:10.14238/sp17.3.2015.163-8

2016

DOI: 10.14238/sp17.3.2015.163-8

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Hubungan Kadar Feritin Serum dengan Fungsi Kognitif Berdasarkan Pemeriksaan Status Mini-Mental (MMSE) pada Penyandang Thalassemia Anak

Fathiyah Ma’ani

Eddy Fadlyana

Sri Endah Rahayuningsih

Abstract: Latar belakang. Penyandang thalassemia yang mendapat transfusi rutin tanpa kelasi besi yang optimal dapat menyebabkan kelebihan besi yang memicu stres oksidatif dan dapat mempercepat proses degenerasi di otak.

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Cited by 2 publications

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“…5 A previous study at Dr. Hasan Sadikin Hospital found that 67% of 10 to14-year-old patients had delayed growth. 7 Another study reported that more than half of thalassemia patients aged 13.8 and >15 years had delayed growth. The delayed growth and puberty might also occur in 12 to 17-year-old thalassemia patients.…”

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confidence: 99%

“…About 65 (81.2%) of the subjects had short stature (stunted and severely stunted, based on height-forage Z-score).Hashemi et al reported that 65.71% of thalassemia patients had short stature 15. Similarly, another study at the Thalassemia Clinic of Dr. Hasan Sadikin Hospital, Bandung on thalassemia patients aged 10-14 years found that 62% had short stature 7. Both studies assessed nutritional status using body mass index for age, with Hashemi et al reporting 81.4% normal and 18.6% malnourished subjects 15.…”

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Serum IGF-1 and short stature in adolescents with beta-thalassemia major

Elizabeth

Fadlyana

Reniarti

et al. 2018

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Background The prevalence of short stature in thalassemia patients ranges from 39.3 to 65%. The cause of short stature is complex and still up for debate. In Indonesia, data on the prevalence and risk factors of short stature in adolescents with thalassemia have been limited. Objective To assess for the prevalence and risk factors of short stature in adolescents with beta-thalassemia major. Methods This cross-sectional study was done from February to March 2017 at the Thalassemia Clinic at Dr. Hasan Sadikin General Hospital, Bandung. The baseline characteristics data of 80 adolescents with thalassemia aged 10-14 years were recorded. Short stature was assessed by height-for-age, (Z-score <-2SD) based on the 2007 WHO Reference Growth Chart. Mid-upper arm circumference was scored according to age and sex and serum IGF-1 was measured by ELISA method. Data analyses used were Chi-square, Fisher’s, and Mann-Whitney tests. Logistic regression model was used to further analyze for risk factors of short stature. Results Subjects were 40 males and 40 females, 81.2% of whom had short stature. The mean serum IGF-1 level was 32.2 (SD 26.38) ng/mL. The IGF-1 cut-off point by ROC curve was £38.51 ng/mL, with sensitivity of 64.4% and specificity of 86.7%. The risk factors of short stature were IGF-1 level £38.51 ng/mL (PR 40.66; 95%CI 4.37 to 377.58; P<0.001) and low family income (PR 19.76; 95%CI: 1.152 to 256.08; P=0.022). Conclusion IGF-1 level may be useful as a predictor of short stature in adolescent beta-thalassemia major patients.

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confidence: 99%

Serum IGF-1 and short stature in adolescents with beta-thalassemia major

Elizabeth

Fadlyana

Reniarti

et al. 2018

Self Cite

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Influence of Working Memory on Academic Achievement and Quality of Life in Children with Beta-Thalassemia Major

Gamayani¹,

Lestari²,

Ganiem³

et al. 2019

TOPSYJ

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Background: Children with beta-thalassemia major may suffer from working memory impairment. For a more refined understanding of this issue, we assessed working memory function in beta-thalassemia children and evaluated its influence on academic achievement and quality of life. Methods: This was a cross-sectional study involving 60 beta-thalassemia children aged 8-12 years. All participants underwent a working memory assessment using the digit span and were interviewed using academic achievement and Indonesian version of PedsQL 4.0 questionnaires. Working memory in beta-thalassemia children significantly influences their quality of life, both directly (β=0.32) and indirectly, through their academic achievement (β=0.639). Longer duration of transfusion (p=0.01) is significantly related to poorer working memory, while lower hemoglobin level (p=0.81) and higher ferritin level (p=0.24) are not significantly associated with working memory. Conclusion: We concluded that working memory influences the quality of life in beta-thalassemia children, both directly and indirectly, through their academic achievement.

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Hubungan Kadar Feritin Serum dengan Fungsi Kognitif Berdasarkan Pemeriksaan Status Mini-Mental (MMSE) pada Penyandang Thalassemia Anak

Abstract: Latar belakang. Penyandang thalassemia yang mendapat transfusi rutin tanpa kelasi besi yang optimal dapat menyebabkan kelebihan besi yang memicu stres oksidatif dan dapat mempercepat proses degenerasi di otak.

Cited by 2 publications

References 15 publications

Serum IGF-1 and short stature in adolescents with beta-thalassemia major

Serum IGF-1 and short stature in adolescents with beta-thalassemia major

Influence of Working Memory on Academic Achievement and Quality of Life in Children with Beta-Thalassemia Major

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