Serum IGF-1 and short stature in adolescents with beta-thalassemia major

Elizabeth, Monalisa; Fadlyana, Eddy; Reniarti, Lelani; Faisal, Faisal; Sukandar, Hadyana; Rusmil, Kusnandi

doi:10.14238/pi58.4.2018.151-8

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…This finding supports the findings of Elizabeth et al (8) and Toumba et al (9) who found that short stature was more common in thalassemia patients.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Psychosocial Morbidity among Children and Adolescents with Beta-Thalassemia Major

Abdelaziz¹,

Elsafi²,

Fattah³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Thalassemia major (TM) is a long-term illness that affects the child and family emotionally and psychologically. Aim: To assess the existence of psychiatric symptoms in thalassemia-affected children and teenagers, such as hysteria, somatic symptoms, obsessive symptoms, depressive symptoms, anxiety, and phobic anxiety. Subjects and methods: This is a case-control study that included 42 children and adolescents who have transfusiondependent beta-thalassemia major and 42 healthy controls. All patients underwent Psychological assessment using a questionnaire by The Arabic version of the Child Behavior Check List (CBCL/6-18). Results: There was a significant difference between the two groups regarding total problems grades that were clinical and borderline in cases more than in the control group. Conclusion:The Arabic version of the Child Behavior Check List identifies behavioral and psychological issues in patients with beta-thalassemia major.

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“…This finding supports the findings of Elizabeth et al (8) and Toumba et al (9) who found that short stature was more common in thalassemia patients.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Psychosocial Morbidity among Children and Adolescents with Beta-Thalassemia Major

Abdelaziz¹,

Elsafi²,

Fattah³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…3 Elizabeth et al did a study on the correlation between serum ferritin level and growth disorders in children with thalassemia and found that the risk factors of short stature were low Insulin-like growth factor (IGF-1) level and low family income. 12 Similarly Saxena et al did a study on growth retardation in thalassemia major patients and found that thalassemic patients are short, have low rate of growth and BMI and have either delayed or absent pubertal spurt, which is related to low hemoglobin and high ferritin level and sub-optimal iron chelation therapy. 13 In our study, ferritin levels did not statistically correlate with growth retardation.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Serum Ferritin Levels with Liver Function Tests and Anthropometric Measurements in Transfusion Dependent Beta-Thalassemia Major Children: A Cross Sectional Study

Harish

Pasha

2019

Pediatric Oncall

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Aim: To determine liver dysfunction and growth in transfusion-dependent beta-thalassemia children of age 2-16 years with iron overload state.Methods: Forty-one children aged 2-16 years with transfusion-dependent beta-thalassemia who were on chelation therapy with oral iron chelator deferasirox for at least 1 year were included in the study. Serum ferritin, growth assessment and liver function tests (LFT) were measured and correlated. Stunting was defined as low height for age (HFA). According to the World Health Organization (WHO), HFA between -2SD to -3SD was defined as moderate stunting and HFA less than -3SD as severe stunting. Spearmen correlation coefficient was used for finding out a correlation among different variables. Multiple linear regression was carried out to estimate the relationship between serum ferritin level, transfusion rate per year, age, sex and HFA status of thalassemia children.Results: Out of 41 children, 25 (60%) patients were in the age group of 5-10 years and the overall median age of the patients was 8 years. The overall median rate of blood transfusion was 12.3 per year and median ferritin levels were 3863 ng/ml (95% CI 2781-4860). There was a significant relationship between ferritin level and transfusion rate per year (p=0.048). The median aspartate aminotransferase (AST) was 51 IU/L (95% CI 43-66), alanine aminotransferase (ALT) 45 IU/L (95% CI 31-58). There was a significant relationship between ferritin level and AST, ALT levels (p<0.005) with correlation coefficient 0.31 and 0.55 respectively. AST and ALT levels were rising as the serum ferritin was increasing and after the level of 3000 ng/ml, there was a steep rise. Moderate stunting was seen in 9 (23%) patients with median ferritin level of 3452 ng/ml (95% CI 370-4992 ), severe stunting was present in 14 (34%) patients with median ferritin level of 4432 ng/ml (95% CI 2781 -4860 ) and normal height was seen in 18 (44%) cases with median ferritin level of 3992 ng/ml (95% CI 1904-4862) (p=0.4). Conclusion:High serum ferritin levels in beta-thalassemia are associated with hepatic dysfunction. Hence liver functions should be monitored frequently in patients with beta-thalassemia major. In our study, we found many children with stunting, but stunting is not affected by iron overload states.

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Vitamin D, insulin-like growth factor-1, and stunting in children with transfusion-dependent thalassemia

Pratiwi

Irawan

Ugrasena

et al. 2022

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Background Transfusion-dependent thalassemia (TDT) has a major impact on a child’s growth and is associated with stunting, risk of vitamin D deficiency, and decreased insulin-like growth factor-1 (IGF-1). To date, the relationship between vitamin D levels and stunting in TDT remains unclear. Futhermore, the role of vitamin D and IGF-1 in mediating stunting in TDT patients is still unknown. Objective To investigate the relationship between stunting and vitamin D as well as IGF-1 levels in children with TDT. Methods This cross-sectional study involved 50 TDT children aged 5 to 18 years, included consecutively from the Pediatric Hemato-oncology Outpatient Clinic, Dr. Soetomo Hospital, Surabaya, East Java. Subjects were divided into two groups: stunted (S) and not stunted (NS). Vitamin D and IGF-1 were evaluated by antibody competitive immunoassay and sandwich-enzyme-linked immunosorbent assay (ELISA), respectively. Age, sex, and duration of repeated transfusion were analyzed as confounding factors. Results Median IGF-1 levels were 91.43 (13.67-192.86) ng/mL and 161.53 (17.99-363.01) ng/mL in the S and NS groups, respectively (P=0.011). Mean vitamin D levels were 20 (+ 5.71) ng/mL and 20.46 (5.25) ng/mL in the S and NS groups, respectively (P=0.765). The correlation coefficient (r) of vitamin D and IGF-I levels was not significant. Multivariate analysis showed that low IGF-1 levels, male, and longer duration of repeated transfusions were associated with stunting in children with TDT. Conclusion Low IGF-1 level is associated with stunting in children with TDT. Vitamin D is not significantly associated with either stunting or IGF-1 in children with TDT.

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Serum IGF-1 and short stature in adolescents with beta-thalassemia major

Cited by 3 publications

References 20 publications

Evaluation of Psychosocial Morbidity among Children and Adolescents with Beta-Thalassemia Major

Evaluation of Psychosocial Morbidity among Children and Adolescents with Beta-Thalassemia Major

Correlation of Serum Ferritin Levels with Liver Function Tests and Anthropometric Measurements in Transfusion Dependent Beta-Thalassemia Major Children: A Cross Sectional Study

Vitamin D, insulin-like growth factor-1, and stunting in children with transfusion-dependent thalassemia

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